[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100286410":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":33,"centralContacts":37,"locations":46,"responsibleParty":67,"collaborators":10,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":10,"eligibilityCriteria":75,"healthyVolunteers":72,"sex":76,"minAge":77,"maxAge":10,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":10,"overallStatus":48,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Heart Failure Group",null,"Patients who have any QRS duration and left ventricular ejection fraction (LVEF) ≤ 50% will be enrolled in this arm. The primary care physician will have recommended either PM, CRT-D Implantation, CRT-P Implantation, HIBP or LBAP (including HIBP\u002FLBAP for patients with HF, for patients who have failed CRT implant or patients who are CRT non-responders) . (This is Standard of Care for this patient population; the procedures will occur even if the patient does not participate in the study.)",[13,14],"Procedure: CRT-D Implantation","Procedure: CRT-P Implantation",{"label":16,"type":10,"description":17,"interventionNames":18},"Atrioventricular Block\u002FBradycardia Group","Patients who have developed second or third degree atrioventricular block (AV block) or bradycardia will be enrolled in this arm. The primary care physician will have recommended dual chamber pacemaker implantation. (This is Standard of Care for this patient population; the procedures will occur even if the patient does not participate in the study.)",[19],"Procedure: Dual Chamber Pacemaker Implantation",[21,26,30],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"PROCEDURE","CRT-D Implantation","Cardiac resynchronization therapy defibrillator",[9],{"type":22,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"CRT-P Implantation","Cardiac resynchronization therapy pacemaker",[9],{"type":22,"name":31,"description":10,"armGroupLabels":32,"otherNames":10},"Dual Chamber Pacemaker Implantation",[16],[34],{"name":35,"affiliation":5,"role":36},"Yong-Mei Cha, M.D.","PRINCIPAL_INVESTIGATOR",[38,42],{"name":35,"role":39,"phone":40,"phoneExt":10,"email":41},"CONTACT","(507) 255-2440","ycha@mayo.edu",{"name":43,"role":39,"phone":44,"phoneExt":10,"email":45},"Brent W Quam","507-422-3235","quam.brent@mayo.edu",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-92.4699,44.02163,{"lat":58,"lon":57},[61,63,65],{"name":62,"role":39,"phone":40,"phoneExt":10,"email":41},"Yong-mei Cha",{"name":64,"role":39,"phone":44,"phoneExt":10,"email":45},"Brent Quam",{"name":66,"role":36,"phone":10,"phoneExt":10,"email":10},"Yong-Mei Cha",{"type":68,"investigatorFullName":66,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","M.D., Professor of Medicine","100286410","his-bundle-pacing-in-bradycardia-and-heart-failure-100286410",false,"NCT03008291","His Bundle Pacing in Bradycardia and Heart Failure","Inclusion Criteria:\n\nHF Group\n\n* Clinically recommended to undergo PM, CRT-P, or CRT-D implantation or HIBP\u002FLBAP (including HIBP\u002FLBAP for patients with HF, for patients who have failed CRT implant or patients who are CRT non-responders)\n* Any QRS duration\n* LVEF ≤ 50%\n\nAV Block\u002FBradycardia Group\n\n* Recommended to undergo dual chamber pacemaker implantation\n* Any AV block or Sinus Bradycardia\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Pregnant","ALL","18 Years",{"count":79,"type":80},80,"ESTIMATED","OBSERVATIONAL","Participants in this study will either have heart failure (HF) and are scheduled to undergo pace maker (PM) implantation, cardiac resynchronization therapy pacemaker (CRT-P), cardiac resynchronization therapy defibrillator (CRT-D) implantation, His bundle pacing (HIBP) or left bundle area pacing (LBAP) (including HIBP\u002FLBAP for patients with HF, for patients who have failed CRT implant or patients who are CRT non-responders), or have atrioventricular (AV) block or bradycardia and are scheduled to undergo dual chamber pacemaker implantation. In this study additional heart rhythm measurements will be collected during the implant procedure to better understand how His bundle and\u002For parahisian pacing (HISP) effects electrical conduction in the hearts of patients with HF or AV block.\n\nThe hypothesis is that His bundle or parahisian pacing (HISP) and left bundle area pacing (LBAP) may normalize atrioventricular (AV) conduction with a narrow combination of the Q wave, R wave and S wave (QRS complex) in functional bundle branch block or conduction delay in patients with heart failure (HF).",[84,85],"Bradycardia","Heart Failure","2025-12-22",{"date":88,"type":89},"2025-12-24","ACTUAL",{"date":91,"type":10},"2016-10",{"date":93,"type":80},"2026-12",{"name":66,"class":6},1]