[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100550998":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":13,"locations":22,"responsibleParty":38,"collaborators":40,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":47,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":59,"studyType":60,"phases":7,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":24,"whyStopped":7,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Centre Hospitalier de Mâcon","OTHER",null,[9],{"name":10,"affiliation":11,"role":12},"Thibault MAILLET","Internal Medicine - Centre Hospitalier de Mâcon","PRINCIPAL_INVESTIGATOR",[14,18],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},"CONTACT","+33 3 85 27 73 43","thmaillet@ch-macon.fr",{"name":19,"role":15,"phone":20,"phoneExt":7,"email":21},"Thomas MALDINEY","+33 3 85 91 01 11","thomas.maldiney@ch-chalon71.fr",[23],{"facility":5,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"RECRUITING","Mâcon","Sâone-et-Loire","71000","France","FR",{"type":31,"coordinates":32},"Point",[33,34],4.82823,46.31407,{"lat":34,"lon":33},[37],{"name":10,"role":15,"phone":16,"phoneExt":7,"email":17},{"type":39,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[41,43],{"name":42,"class":6},"Centre Hospitalier William Morey - Chalon sur Saône",{"name":44,"class":6},"Centre Hospitalier Universitaire Dijon","100550998","histopathological-analysis-versus-full-field-optical-coherence-tomography-of-minor-salivary-gland-biopsy-in-suspect-sjogren-syndrome-100550998",false,"NCT06454370","Histopathological Analysis Versus Full-field Optical Coherence Tomography of Minor Salivary Gland Biopsy in Suspect Sjogren Syndrome","Histopathological Analysis of Minor Salivary Gland Biopsy Following Dynamic Full-field Optical Coherence Tomography, a Comparison to Conventional Histopathological Findings in Patients Suspect Sjogren Syndrome.","TOCOSS","Inclusion Criteria:\n\n* Patient \\> 18 years of age with suspected Sjogren Syndrome received minor gland salivary biopsy\n\nExclusion Criteria:\n\n* Inability to perform dynamic full-field optical coherence tomography observation at the moment of temporal artery biopsy","ALL","18 Years","99 Years",{"count":57,"type":58},30,"ESTIMATED","1 Month","OBSERVATIONAL","Primary Sjögren syndrome (pSS) is a systemic autoimmune disease that mainly affects the exocrine glands leading to severe dryness of mucosal surfaces, principally in the mouth and eyes. The other clinical manifestations are fatigue and musculoskeletal pain. Diagnosis of pSS associates clinical abnormalities with specific antibodies (Ro\u002FSSA and La\u002FSSB antibodies) or histopathological criteria of a minor salivary gland biopsy (the presence and number of lymphocytic focus, as well as chronicity findings like acinar atrophy, ductal dilatation or fibrosis). Apart from its variable sensitivity, one of the weaknesses of minor salivary gland biopsy is the delay in obtaining the result due to the time required to prepare the sample for histological analysis.\n\nOur group recently demonstrated the use of full-field optical coherence tomography (FF-OCT) to visualize structural changes associated with the inflammatory processes in Giant Cell Arteritis (temporal artery biopsy examination). It may suggests a further use of dynamic FF-OCT of minor salivary gland biopsy to visualize structural changes associated with the lymhocytic focus to ensure rapid on-site diagnosis of pSS.",[63,64],"Sjogren's Syndrome","Tomography Optical Coherence",[66,67],"Minor Salivary gland biopsy","Tomography, Optical Coherence","2024-06-11",{"date":70,"type":71},"2024-06-12","ACTUAL",{"date":73,"type":71},"2024-06-07",{"date":75,"type":58},"2024-12-07",{"name":5,"class":6},1]