[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626040":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":31,"responsibleParty":50,"collaborators":26,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":26,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":26,"enrollmentInfo":63,"targetDuration":26,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":79,"whyStopped":26,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"European University of Madrid","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exergame-Based Semi-Autonomous Program","EXPERIMENTAL","Participants will complete a semi-autonomous home-based exergame rehabilitation program targeting upper-limb motor and sensory function. The program integrates multisensory feedback, motor sequencing, coordination, and dual-task demands. Remote supervision will be provided by a physiotherapist.\n\nDose: 30-40 minutes per session, 5 sessions\u002Fweek for 8 weeks\n\nMode of Delivery: Home-based with remote monitoring",[13],"Behavioral: Exergame-Based Upper Limb Rehabilitation Program",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Physiotherapy Program","ACTIVE_COMPARATOR","Participants will complete an individualized home-based physiotherapy program including strengthening exercises and functional upper-limb tasks, matched in duration and frequency to the experimental arm.\n\nDose: 30-40 minutes per session, 5 sessions\u002Fweek for 8 weeks\n\nMode of Delivery: Home exercise program with standard follow-up",[19],"Behavioral: Conventional Home-Based Physiotherapy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"BEHAVIORAL","Exergame-Based Upper Limb Rehabilitation Program","Participants in the experimental group will complete a semi-autonomous home-based exergame rehabilitation program targeting upper-limb motor, sensory, and perceptual function. The intervention integrates intensive motor practice, multisensory feedback, dual-task demands, visuomotor coordination, and progressive task difficulty. Remote supervision will be provided by a physiotherapist to monitor adherence, adjust progression, and ensure safety.\n\nDose and Schedule:\n\n5 sessions per week 30-40 minutes per session Duration: 8 weeks\n\nMode of Delivery:\n\nHome-based training using therapeutic exergames, with remote monitoring and session review by a physiotherapist.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional Home-Based Physiotherapy","Participants in the control group will follow a conventional individualized physiotherapy program focused on upper-limb motor rehabilitation. The program includes strengthening exercises, functional upper-limb tasks, and repetitive practice designed to match the dose and duration of the experimental group.\n\nDose and Schedule:\n\n5 sessions per week 30-40 minutes per session Duration: 8 weeks\n\nMode of Delivery:\n\nHome-based exercises with standard clinical follow-up and therapist support as needed.",[15],[32],{"facility":33,"status":26,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Universidad Europea de Madrid","Villaviciosa de Odón","Madrid","28670","Spain","ES",{"type":40,"coordinates":41},"Point",[42,43],-3.9043,40.3581,{"lat":43,"lon":42},[46],{"name":47,"role":48,"phone":26,"phoneExt":26,"email":49},"Marina Castel-Sánchez, PhD","CONTACT","marina.castel@universidadeuropea.es",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Marina Castel Sánchez","Associate Professor","100626040","home-based-exergame-rehabilitation-for-upper-limb-function-in-people-with-multiple-sclerosis-100626040",false,"NCT07430462","Home-Based Exergame Rehabilitation for Upper Limb Function in People With Multiple Sclerosis","Effectiveness and Feasibility of a Home-Based Exergame Rehabilitation Protocol for Upper Limb Function in Individuals With Multiple Sclerosis: A Randomized Controlled Pilot Trial","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Clinical diagnosis of Multiple Sclerosis with EDSS score between 2.0 and 6.5, with upper-limb involvement.\n* Ability to maintain independent sitting and to stand with or without assistive devices.\n* Upper-limb functional capacity between 11 and 54 points on the ARAT, indicating limited to substantial impairment.\n* Cognitive ability to understand and follow simple instructions, demonstrated by a Mini-Mental State Examination score ≥ 23.\n* Provision of written informed consent by the participant or legally authorized representative.\n\nExclusion Criteria:\n\n* Acute illness, musculoskeletal injury, or pain interfering with the ability to perform the intervention exercises.\n* Uncompensated visual or hearing impairments that limit participation.\n* Disruptive behavior or other conditions that significantly hinder participation in the rehabilitation program.\n* Active epilepsy or any medical contraindication to physical exercise.\n* Botulinum toxin treatment in the upper limb within the previous 6 months.","ALL","18 Years",{"count":64,"type":65},40,"ESTIMATED","INTERVENTIONAL",[68],"NA","This randomized pilot clinical trial aims to evaluate the effectiveness, feasibility, and cost-effectiveness of a semi-autonomous upper-limb rehabilitation program based on therapeutic exergames in people with Multiple Sclerosis (MS). The intervention integrates intensive motor practice, multisensory feedback, and cognitively demanding tasks to enhance upper-limb function, dexterity, and patient autonomy. Participants will be randomly assigned to either an exergame-based home rehabilitation program with remote physiotherapist supervision or a dose-matched conventional home-based physiotherapy program.\n\nThe primary outcome is upper-limb functionality measured by the Action Research Arm Test (ARAT). Secondary outcomes include motor function, manual ability, quality of life, usability, adherence, and digital performance metrics related to the execution of motor and cognitive tasks. Follow-up at 16 weeks will assess the sustainability of treatment effects.\n\nThis study seeks to generate evidence on whether exergame-based rehabilitation can serve as an accessible, scalable, and patient-centered alternative to conventional home-based upper-limb rehabilitation for individuals with MS.",[71],"Multiple Sclerosis",[71,73,74,75,76,77,78],"Upper Limb Rehabilitation","Exergames","Home-Based Rehabilitation","Virtual Reality Rehablitation","Cost-effectiveness","Usability","NOT_YET_RECRUITING","2026-02-18",{"date":82,"type":83},"2026-02-24","ACTUAL",{"date":85,"type":65},"2026-04",{"date":87,"type":65},"2026-12",{"name":52,"class":6},1]