[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642091":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":40,"responsibleParty":56,"collaborators":58,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":26,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":26,"overallStatus":82,"whyStopped":26,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Aquilo Sports, LLC","INDUSTRY",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Lower-Extremity Heat Therapy","EXPERIMENTAL","Participants assigned to this arm will complete home-based lower-extremity heat therapy sessions for 90 minutes per day for 12 weeks. The active therapy condition will use heated lower-extremity garments according to the study protocol.",[13],"Device: Lower-Extremity Heat Therapy",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham Lower-Extremity Heat Therapy","SHAM_COMPARATOR","Participants assigned to this arm will complete sham home-based lower-extremity therapy sessions for 90 minutes per day for 12 weeks. The sham condition will use the same treatment schedule and similar lower-extremity garments, with a lower-temperature condition designed to preserve participant blinding while minimizing the expected physiological effects of active heat therapy.",[19],"Device: Sham Lower-Extremity Heat Therapy",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Lower-Extremity Heat Therapy","Participants assigned to the active intervention will complete home-based lower-extremity heat therapy sessions for 90 minutes per day for 12 weeks. The active condition will deliver heated therapy to the lower extremities according to the study protocol.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"Participants assigned to the sham comparator will complete home-based sham therapy sessions for 90 minutes per day for 12 weeks. The sham condition will use the same treatment schedule and similar lower-extremity garments as the active condition, but will use a lower-temperature condition intended to support participant blinding while minimizing the expected physiological effects of active heat therapy.",[15],[31],{"name":32,"affiliation":33,"role":34},"Raghu Motaganahalli, MD","Indiana University","PRINCIPAL_INVESTIGATOR",[36],{"name":32,"role":37,"phone":38,"phoneExt":26,"email":39},"CONTACT","317-962-2300","rmotagan@iu.edu",[41],{"facility":42,"status":26,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Methodist Hospital","Indianapolis","Indiana","46202","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-86.15804,39.76838,{"lat":52,"lon":51},[55],{"name":32,"role":37,"phone":38,"phoneExt":26,"email":39},{"type":57,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR",[59,61],{"name":33,"class":60},"OTHER",{"name":62,"class":60},"Purdue University","100642091","home-based-lower-extremity-heat-therapy-for-walking-function-in-peripheral-artery-disease-100642091",false,"NCT07653243","Home-Based Lower-Extremity Heat Therapy for Walking Function in Peripheral Artery Disease","A Randomized, Sham-Controlled Trial of Home-Based Lower-Extremity Heat Therapy in Adults With Peripheral Artery Disease","Inclusion Criteria:\n\n* Men and women older than 50 years of age\n* Resting ankle-brachial index (ABI) of \\\u003C0.9 but \\>0.4 in at least one leg\n\nExclusion Criteria:\n\n* Critical limb ischemia (ischemic rest pain or ischemia-related, non-healing wounds or tissue loss\n* Prior amputation\n* Exercise-limiting comorbidity\n* Recent (\\\u003C3 months) lower-extremity revascularization or orthopedic surgery\n* Use of walking aid other than a cane\n* Active treatment for cancer\n* Chronic kidney disease (eGFR \\\u003C30 by MDRD or Mayo or Cockcroft-Gault formula)\n* Class 2 or 3 obesity (BMI ≥ 35 kg\u002Fm2)\n* Unable to fit into water-circulating trousers","ALL","50 Years",{"count":73,"type":74},40,"ESTIMATED","INTERVENTIONAL",[77],"NA","Lower-extremity peripheral artery disease is associated with impaired walking ability, reduced lower-extremity function, and decreased quality of life. This randomized, sham-controlled clinical trial will evaluate the effects of 12 weeks of home-based lower-extremity heat therapy on walking function and mobility in adults with peripheral artery disease.\n\nA total of 40 participants will be randomized to active lower-extremity heat therapy or sham therapy. Participants assigned to active therapy will complete daily 90-minute home treatment sessions using heated lower-extremity garments. Participants assigned to sham therapy will complete the same treatment schedule using a lower-temperature sham condition.\n\nThe primary outcome is the change in six-minute walk distance from baseline to 12 weeks. Secondary outcomes include changes in leg strength and fatigability, Short Physical Performance Battery score, blood pressure, and patient-reported quality of life.",[80,81],"PAD","PAD - Peripheral Arterial Disease","NOT_YET_RECRUITING","2026-06-12",{"date":85,"type":86},"2026-06-17","ACTUAL",{"date":88,"type":74},"2027-01-01",{"date":90,"type":74},"2029-06-30",{"name":5,"class":6},1]