[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100473362":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":34,"responsibleParty":54,"collaborators":19,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":19,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":19,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":19,"overallStatus":37,"whyStopped":19,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Hugo W. Moser Research Institute at Kennedy Krieger, Inc.","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Home exercise","EXPERIMENTAL","Individually designed home exercise program",[13],"Behavioral: Home exercise",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"BEHAVIORAL","Exercise to address limitations impacting walking",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Jennifer Keller, PT","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Jennifer L Keller, PT, MS","CONTACT","443-923-2716","keller@kennedykrieger.org",{"name":31,"role":27,"phone":32,"phoneExt":19,"email":33},"Amena Smith Fine, MD PhD","443-923-3249","finea@kennedykrieger.org",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Kennedy Krieger Institute","RECRUITING","Baltimore","Maryland","21205","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-76.61219,39.29038,{"lat":47,"lon":46},[50,52],{"name":51,"role":27,"phone":32,"phoneExt":19,"email":33},"Amena Smith Fine, MD, PhD",{"name":22,"role":27,"phone":53,"phoneExt":19,"email":29},"4439232716",{"type":23,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"jennifer keller","Physical Therapist","100473362","home-exercise-for-individuals-with-neurodegenerative-disease-100473362",false,"NCT05443906","Home Exercise for Individuals with Neurodegenerative Disease","Study of Adapted Exercise and Mindfulness Interventions to Improve Motor Function and Sleep Quality in Individuals with Neurodegenerative Disease","Inclusion Criteria:\n\n* The eligibility criteria for males is X-linked adrenoleukodystrophy as determined by biochemical determination or genetic testing.\n* The eligibility criteria for females is X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis.\n* The Leukoenceophalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion is a confirmed DARS2 mutation through genetic analysis.\n* For people with cerebellar ataxia, people with diagnoses of cerebellar damage from stroke, tumor or degeneration will be included. Those with a genetically confirmed cerebellar disorder will be asked to provide their genetic testing to note their particular type of ataxia.\n* We will also include patients with other neurodegenerative diseases similar to these disorders as determined by chart review and clinical exam.\n\nHealthy Volunteers\n\n* Able to stand for 30 seconds without upper extremity support\n* Ambulatory (including use of a cane or a walker)\n* Able to walk for 2 minutes\n\nExclusion Criteria:\n\n* Other medical or psychological conditions which in the clinical judgement of the investigator would interfere with acquiring the study information or performing the exercises safely including but not limited to:\n\nUncontrolled hypertension, orthopedic conditions, diabetes, seizure disorder, peripheral vestibular loss, severe aphasia, dementia, pregnancy",true,"ALL","5 Years","75 Years",{"count":69,"type":70},30,"ESTIMATED","INTERVENTIONAL",[73],"NA","The primary goal of this study is to address the need for targeted therapeutic interventions for impairments that impact walking in related neurodegenerative diseases.",[76,77,78,79,80,81,82,83],"Neurodegenerative Diseases","Leukodystrophy","Ataxia","LBSL","Leukoencephalopathy with Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)","Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation","Cerebellar Ataxia","Adrenomyeloneuropathy","2025-03-06",{"date":86,"type":87},"2025-03-10","ACTUAL",{"date":89,"type":87},"2023-02-13",{"date":91,"type":70},"2027-07-30",{"name":5,"class":6},1]