[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629868":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":52,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":57,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":68,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Necmettin Erbakan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Elevated Homocysteine Group",null,"Patients with newly diagnosed essential hypertension and plasma homocysteine levels greater than 15 µmol\u002FL.",[13],"Diagnostic Test: Homocysteine Measurement and Echocardiography",{"label":15,"type":10,"description":16,"interventionNames":17},"Normal Homocysteine Group","Patients with newly diagnosed essential hypertension and plasma homocysteine levels less than or equal to 15 µmol\u002FL.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","Homocysteine Measurement and Echocardiography","Peripheral venous blood sampling for plasma homocysteine measurement and comprehensive transthoracic echocardiography including diastolic function assessment and strain analysis.",[9,15],[25],{"name":26,"affiliation":5,"role":27},"yunus emre yavuz, MD","PRINCIPAL_INVESTIGATOR",[29],{"name":26,"role":30,"phone":31,"phoneExt":32,"email":33},"CONTACT","+90 5306069194","+903322235976","eyavuz@erbakan.edu.tr",[35],{"facility":36,"status":37,"city":38,"state":39,"zip":40,"country":41,"countryCode":10,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Necmettin Erbakan University Meram Faculty of Medicine","RECRUITING","Konya","Meram","42080","Turkey (Türkiye)",{"type":43,"coordinates":44},"Point",[45,46],32.48464,37.87135,{"lat":46,"lon":45},[49],{"name":50,"role":30,"phone":51,"phoneExt":10,"email":33},"YUNUS EMRE YAVUZ, MD","+905306069194",{"type":27,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"yunus emre yavuz","Principal Investigator","100629868","homocysteine-and-early-diastolic-dysfunction-in-newly-diagnosed-hypertension-100629868",false,"NCT07480265","Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension","Relationship Between Elevated Homocysteine Levels and Early Diastolic Dysfunction in Newly Diagnosed Hypertensive Patients","HHT-EDD","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Newly diagnosed essential hypertension within the previous 6 months\n* Ability and willingness to provide informed consent\n* Availability for clinical evaluation, laboratory testing, ambulatory blood pressure monitoring, electrocardiography, and transthoracic echocardiography\n\nExclusion Criteria:\n\n* Resistant hypertension\n* Secondary hypertension\n* Acute coronary syndrome within the previous 6 months\n* Major surgery within the previous 6 months\n* Known heart failure\n* Pulmonary hypertension\n* Congenital heart disease\n* Atrial fibrillation or atrial flutter\n* Moderate or severe valvular heart disease\n* Chronic kidney disease\n* Anemia\n* Current folate, vitamin B12, or vitamin B6 supplementation or treatment\n* Inadequate echocardiographic image quality for strain analysis\n* Known systemic conditions that may significantly affect plasma homocysteine levels","ALL","18 Years",{"count":66,"type":67},500,"ESTIMATED","2 Years","OBSERVATIONAL","This prospective single-center observational study aims to evaluate the relationship between elevated plasma homocysteine levels and early echocardiographic abnormalities in patients with newly diagnosed essential hypertension. Adult patients diagnosed with essential hypertension within the previous 6 months will undergo clinical assessment, ambulatory blood pressure monitoring, electrocardiography, laboratory testing, and comprehensive transthoracic echocardiography including diastolic function assessment and strain analysis when image quality is adequate. Participants will be classified according to plasma homocysteine level using, and patients with elevated and normal homocysteine levels will be compared with respect to diastolic dysfunction and left ventricular and left atrial global longitudinal strain parameters. Clinical, laboratory, and echocardiographic data will also be used to develop a machine-learning based model for prediction of H-type hypertension.",[72,73,74],"Hypertension (HTN)","Hyperhomocysteinemia","Diastolic Dysfunction",[76,77,78,79,80,81,82],"H-type hypertension","Homocysteine","Echocardiography","Diastolic dysfunction","Left ventricular global longitudinal strain","Left atrial global longitudinal strain","Machine learning","2026-03-20",{"date":85,"type":86},"2026-03-24","ACTUAL",{"date":88,"type":86},"2025-06-02",{"date":90,"type":67},"2028-03",{"name":5,"class":6},1]