[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587651":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":45,"centralContacts":54,"locations":60,"responsibleParty":77,"collaborators":45,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":83,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":45,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":62,"whyStopped":45,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Rhode Island Hospital","OTHER",[8,15,20,26],{"label":9,"type":10,"description":11,"interventionNames":12},"OLP + Standard Rationale","EXPERIMENTAL","Participants in this group will receive an open-label placebo along with information based on the standard rationales used in other OLP studies.",[13,14],"Drug: Open-label Placebo","Behavioral: Standard Rationale",{"label":16,"type":10,"description":17,"interventionNames":18},"OLP + Mindfulness Rationale","Participants in this group will receive an open-label placebo along with information with mindfulness information.",[13,19],"Behavioral: Mindfulness",{"label":21,"type":22,"description":23,"interventionNames":24},"OLP + Control Rationale","PLACEBO_COMPARATOR","Participants in this group will receive an open-label placebo along with no information on the placebo effect.. They will receive basic epidemiological information on chronic pain to guarantee structural equivalence of the trial design.",[13,25],"Behavioral: Control Rationale",{"label":27,"type":28,"description":29,"interventionNames":30},"No Treatment + Control Rationale","SHAM_COMPARATOR","Participants in this group will receive no treatment. They will receive basic epidemiological information on chronic pain to guarantee structural equivalence of the trial design.",[25],[32,40,46,50],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"DRUG","Open-label Placebo","Open-label placebo pill for 21 days at 2 per day",[21,16,9],[38,39],"OLP","Zeebo",{"type":41,"name":42,"description":43,"armGroupLabels":44,"otherNames":45},"BEHAVIORAL","Standard Rationale","Scientific rationale about the placebo effect",[9],null,{"type":41,"name":47,"description":48,"armGroupLabels":49,"otherNames":45},"Mindfulness","Mindfulness based rationale",[16],{"type":41,"name":51,"description":52,"armGroupLabels":53,"otherNames":45},"Control Rationale","Basic epidemiological information about chronic pain to achieve structural equivalence for the control groups",[27,21],[55],{"name":56,"role":57,"phone":58,"phoneExt":45,"email":59},"Study Coordination","CONTACT","401-606-4766","HOPE-trial@lifespan.org",[61],{"facility":5,"status":62,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"RECRUITING","Providence","Rhode Island","02906","United States","US",{"type":69,"coordinates":70},"Point",[71,72],-71.41283,41.82399,{"lat":72,"lon":71},[75],{"name":76,"role":57,"phone":58,"phoneExt":45,"email":59},"HOPE Study",{"type":78,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"PRINCIPAL_INVESTIGATOR","Michael Bernstein","Assistant Professor","100587651","honest-placebos-with-explanations-evaluating-open-label-placebos-for-chronic-pain-100587651",false,"NCT06931158","HOnest Placebos With Explanations: Evaluating Open-Label Placebos for Chronic Pain","Optimizing Open Placebos for Chronic Pain Patients","HOPE","Inclusion criteria are:\n\n* chronic pain (pain lasting at least 3 months, pain intensity 4\u002F10 or over and interference 3\u002F10 or over)\n* at least 18 years old\n* English speaking\n* have a smartphone or computer with video access\n* the chronic pain is concentrated into the patient's lower back (tentative criteria based on recruitment rate)\n\nExclusion Criteria\n\n* Have chronic pain because of a cancer diagnosis\n* Over 89 years of age\n* Suspect an allergy to any placebo ingredient\n* Currently receiving worker's compensation.","ALL","18 Years","89 Years",{"count":93,"type":94},340,"ESTIMATED","INTERVENTIONAL",[97],"NA","The goal of this clinical trial is to examine the effect of rationale condition when taking open-label placebos on pain by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other. We also aim to examine the effect of rationale condition on prescription opioid use by 1) comparing each rationale to the no rationale control condition and the no treatment control condition; and 2) comparing the rationale conditions to each other.\n\nThis study will include patients with chronic low back pain. The main question it aims to answer is:\n\nHow do rationales influence the effects of open-label placebos?\n\nResearchers will compare different rationales given when taking an open-label placebo and a no-treatment group and a no rationale group taking OLPs.",[100,101],"Chronic Low-back Pain","Chronic Pain",[103,104,105],"open-label placebo","rationales","placebo effect","2025-04-23",{"date":108,"type":109},"2025-04-27","ACTUAL",{"date":111,"type":109},"2025-03-01",{"date":113,"type":94},"2027-03",{"name":5,"class":6},1]