[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100454163":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":49,"centralContacts":53,"locations":64,"responsibleParty":82,"collaborators":85,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":58,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":58,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":112,"overallStatus":67,"whyStopped":58,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Experimental: Healthy Women Volunteers","Hot Flash frequency will be assessed in the study subjects during a screening period. Participants can then chose to participate 1 or 2 study visits- Protocol 1: Microvascular function and\u002For Protocol 2: Autonomic function",[12,13,14,15,16],"Other: Sympathoexcitatory stressors","Drug: Sodium Nitroprusside","Drug: Acetylcholine","Drug: Terbutaline","Drug: Norepinephrine",[18,24,31,37,43],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"Sympathoexcitatory stressors","Muscle sympathetic nerve activity will be measured continuously at baseline and in response to sympathoexcitatory stressors, including a Valsalva maneuver, isometric handgrip exercise, a cold pressor test, and stepped hypercapnia.",[9],[23],"Valsalva maneuver, handgrip exercise, ice water, and hypercapnia",{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DRUG","Sodium Nitroprusside","Sodium nitroprusside, used to test endothelium-independent vasodilation, will be infused through a brachial artery catheter at 0.25, 0.5, 1.0 and 2.0 ug\u002F100ml tissue\u002Fmin.",[9],[30],"Forearm vascular conductance response to sodium nitroprusside",{"type":25,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Acetylcholine","Acetylcholine, used to test endothelium-dependent vasodilation, will be infused through a brachial artery catheter at 1.0, 2.0, 4.0, and 8.0 μg\u002F100ml tissue\u002Fmin",[9],[36],"Forearm vascular conductance response to acetylcholine",{"type":25,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Terbutaline","Terbutaline, a β2-Adrenergic selective agonist, will be infused through a brachial artery catheter at 0.1, 0.5, 1.0, and 2.0 μg\u002F100ml tissue\u002Fmin.",[9],[42],"Forearm vascular conductance response to terbutaline",{"type":25,"name":44,"description":45,"armGroupLabels":46,"otherNames":47},"Norepinephrine","Norepinephrine, an α-adrenergic vasoconstricting agent, will be infused through a brachial artery catheter at 1.0, 2.0, 4.0, and 8.0 ng\u002F100ml tissue\u002Fmin",[9],[48],"Forearm vascular conductance response to norepinephrine",[50],{"name":51,"affiliation":5,"role":52},"Sarah Baker, PhD","PRINCIPAL_INVESTIGATOR",[54,60],{"name":55,"role":56,"phone":57,"phoneExt":58,"email":59},"Pamela A Engrav","CONTACT","507-255-6938",null,"engrav.pamela@mayo.edu",{"name":61,"role":56,"phone":62,"phoneExt":58,"email":63},"Nancy J Meyer","507-255-0913","meyer.nancy2@mayo.edu",[65],{"facility":66,"status":67,"city":68,"state":69,"zip":70,"country":71,"countryCode":72,"cosmosGeoPoint":73,"geoPoint":78,"contacts":79},"Mayo Clinic in Rochester","RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":74,"coordinates":75},"Point",[76,77],-92.4699,44.02163,{"lat":77,"lon":76},[80,81],{"name":55,"role":56,"phone":57,"phoneExt":58,"email":58},{"name":61,"role":56,"phone":62,"phoneExt":58,"email":58},{"type":52,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":58,"oldOrganization":58},"Sarah E. Baker, Ph.D.","Principal Investigator",[86,89],{"name":87,"class":88},"National Institutes of Health (NIH)","NIH",{"name":90,"class":88},"National Heart, Lung, and Blood Institute (NHLBI)","100454163","hot-flashes-and-neurovascular-function-in-women-100454163",false,"NCT05193968","Hot Flashes and Neurovascular Function in Women","Inclusion Criteria:\n\n* Non-smokers.\n* Non-obese.\n* Have at least one ovary.\n* Free from cardiovascular disease.\n* Not taking medications influencing cardiovascular function.\n\nExclusion Criteria:\n\n\\- None.",true,"FEMALE","40 Years","60 Years",{"count":102,"type":103},120,"ESTIMATED","INTERVENTIONAL",[106],"NA","Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship. As such, these studies are designed to provide a major step forward in understanding the link between hot flashes and neurovascular dysfunction and, by extension, cardiovascular disease in women.",[109,110,111],"Hot Flashes","Menopause","Vasomotor System; Labile",[113,114,115],"Neurovascular function","Autonomic function","Microvascular Function","2026-06-10",{"date":118,"type":119},"2026-06-12","ACTUAL",{"date":121,"type":119},"2022-02-24",{"date":123,"type":103},"2026-12",{"name":5,"class":6},1]