[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100588069":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":25,"responsibleParty":33,"collaborators":25,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":39,"sex":45,"minAge":46,"maxAge":47,"enrollmentInfo":48,"targetDuration":25,"studyType":51,"phases":52,"briefSummary":54,"conditions":55,"keywords":59,"overallStatus":63,"whyStopped":25,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":25},{"fullName":5,"class":6},"Minia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"control group","PLACEBO_COMPARATOR","Fifteen patients will receive Phase I therapy; reevaluation after four weeks then will be treated with a placebo membrane",[13],"Drug: Ascorbic acid",{"label":15,"type":16,"description":17,"interventionNames":18},"study group","ACTIVE_COMPARATOR","Fifteen patients will receive Phase I therapy; reevaluation after four weeks then will be treated with membrane loaded by Ascorbic acid",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Ascorbic acid","Ascorbic acid induce gingival healing",[9,15],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"shaimaa Hamdy, lecturer of Periodontology","CONTACT","+201030576405","+201555035523","shimaa.3m.sh@gmail.com",{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","shaimaa hamdy","lecturer of periodontology","100588069","how-can-prefabricated-membranes-load-ascorbic-acid-can-curtail-gingival-recession-100588069",false,"NCT06936592","How Can Prefabricated Membranes Load Ascorbic Acid Can Curtail Gingival Recession?","How Can Prefabricated Membrane-loaded Ascorbic Acid Curtail the Gingival Recession?","recession","Inclusion Criteria:\n\n1. Patients of both genders with ages more than 18 years.\n2. At least two adjacent teeth in maxillary or mandibular anterior sextant with Cairo classification (RT1 or RT 2) labial GR defect.\n3. Good general health with no contraindications for periodontal surgery (American Society of Anesthesiologists I).\n4. Non-smoker patients.\n\nExclusion Criteria:\n\n1. Pregnant and lactating women.\n2. Teeth exhibiting pathologic mobility.\n3. Mal alignment teeth.\n4. Patients under active orthodontic therapy.\n5. Periodontal therapy during the last 6 months.\n6. Patients received antibiotics or non-steroidal anti-inflammatory drugs six months before the beginning of the study.","ALL","18 Years","55 Years",{"count":49,"type":50},30,"ESTIMATED","INTERVENTIONAL",[53],"NA","Periodontal diseases are a prevalent issue, often leading to gingival recession, where the gingival margin recedes, exposing the tooth root and causing various problems. Gingival recession can be managed through both non-surgical and surgical interventions The non-surgical approach often involves plaque control and addressing any underlying inflammatory conditions. However, in cases of advanced recession, surgical treatment may be necessary Several treatment techniques have been proposed, which can be divided into pedicle and free grafts. The latter can also be classified as free gingival grafts (FGG) or as connective tissue grafts (CTG). Other treatment options include soft tissue substitutes or regenerative therapies Harvesting graft from the palate has several problems, such as pain, inflammation, bleeding, flap necrosis, and infection at the donor site. For this reason, we need a substitute for soft tissue graft harvesting Carbopol polymers, also known as carbomers, are widely utilized in pharmaceutical formulations for their excellent mucoadhesive properties. This high molecular weight, cross-linked acrylic acid polymers are particularly effective in enhancing the adhesion of formulations to mucosal surfaces, thereby improving drug delivery and bioavailability",[56,57,58],"Gingival Recession, Localized","Gingival Diseases","Recession, Gingival",[43,60,61,62],"membrane","ascorbic acide","graft","NOT_YET_RECRUITING","2025-04-17",{"date":66,"type":67},"2025-04-20","ACTUAL",{"date":64,"type":50},{"date":70,"type":50},"2025-10-18",{"name":5,"class":6}]