[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100607641":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":64,"collaborators":66,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":25,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":51,"whyStopped":25,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"University Hospital, Toulouse","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Learning abilities for Patients with an amnesic syndrome","EXPERIMENTAL","1 MRI session, 2 cognitive research tasks of semantic learning, and neuropsychological assessment.",[13,14],"Other: MRI","Other: Psychometric",{"label":16,"type":17,"description":18,"interventionNames":19},"Healthy controls","ACTIVE_COMPARATOR","To allow multiple pairing for each patient, a group of 120 healthy controls aged between 18 to 70 years old will be recruited. Thus, it will be possible to compare one given patient to a group of 40 aged-matched subjects.\n\nAll healthy volunteers will undergo the same intervention as the patients :\n\n1 MRI session, 2 cognitive research tasks of semantic learning, neuropsychological assessment.",[13,14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"MRI","structural and functional resting state MRI",[16,9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Psychometric","2 cognitive research tasks of semantic learning and neuropsychological assessment",[16,9],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Jérémie PARIENTE, MD + PHD","CONTACT","05 61 77 94 88","pariente.j@chu-toulouse.fr",[37,49],{"facility":38,"status":39,"city":40,"state":25,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":25},"University Hospital of Caen","ACTIVE_NOT_RECRUITING","Caen","France","FR",{"type":44,"coordinates":45},"Point",[46,47],-0.35912,49.18585,{"lat":47,"lon":46},{"facility":50,"status":51,"city":52,"state":25,"zip":25,"country":41,"countryCode":42,"cosmosGeoPoint":53,"geoPoint":57,"contacts":58},"University Hospital of Toulouse","RECRUITING","Toulouse",{"type":44,"coordinates":54},[55,56],1.44367,43.60426,{"lat":56,"lon":55},[59,60],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":61,"role":33,"phone":62,"phoneExt":25,"email":63},"Clémence Le Bervet, MASTER","0561777087","drci.toulouse@chu-toulouse.fr",{"type":65,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[67],{"name":68,"class":6},"National Research Agency, France","100607641","how-do-patients-with-amnesia-acquire-new-knowledge-100607641",false,"NCT07191197","How do Patients With Amnesia Acquire New Knowledge?","New Semantic Learning in Patients With Selective Brain Lesions in Temporal Regions: a Behavioural and MRI Study","ASSAM","Inclusion Criteria:\n\n* Patients aged between 18 and 70 years\n* Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation\n* Written agreement to participate in the study\n* Intellectual capacities compatible with the cognitive tasks and signing of consent\n* Affiliation to the French social security system\n* For patients: bilateral brain lesion of the medial temporal lobe or the extended hippocampal system\n\nExclusion Criteria:\n\n* Subjects under the age of 18 or over 70\n* Contraindications for MRI (examples: wearers of a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, wearers of haemostatic clips for intracerebral aneurysms or carotid arteries, wearers of orthopedic implants, claustrophobic)\n* Refusal to be informed of an anomaly detected during the MRI",true,"ALL","18 Years","70 Years",{"count":82,"type":83},150,"ESTIMATED","INTERVENTIONAL",[86],"NA","THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.",[89,90],"Amnesia","Memory Disorder",[92,93,94,95],"Learning","Semantic memory","Hippocampus","Temporal pole","2026-05-07",{"date":98,"type":99},"2026-05-08","ACTUAL",{"date":101,"type":99},"2026-04-08",{"date":103,"type":83},"2030-01-31",{"name":5,"class":6},2]