[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627146":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":23,"centralContacts":27,"locations":10,"responsibleParty":35,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":39,"sex":45,"minAge":46,"maxAge":10,"enrollmentInfo":47,"targetDuration":10,"studyType":50,"phases":10,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":62,"whyStopped":10,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":10},{"fullName":5,"class":6},"East Lancashire Hospitals NHS Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preoperative biliary drainage",null,"Patients who undergo pre op biliary drainage before surgery",[13],"Procedure: Pre operative biliary drainage",{"label":15,"type":10,"description":16,"interventionNames":10},"No pre operative biliary drainage","Patients who proceed straight to surgery",[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"PROCEDURE","Pre operative biliary drainage","ERCP or PTC",[9],[24],{"name":25,"affiliation":5,"role":26},"Daren Subar","STUDY_DIRECTOR",[28,33],{"name":29,"role":30,"phone":31,"phoneExt":10,"email":32},"Zak Shehata, MBChB","CONTACT","+447792068440","zakshehata@doctors.org.uk",{"name":25,"role":30,"phone":10,"phoneExt":10,"email":34},"Daren.Subar@elht.nhs.uk",{"type":36,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100627146","how-does-pre-operative-biliary-drainage-in-pancreatic-adenocarcinoma-affect-surgical-outcomes-in-pancreatic-cancer-surgery-100627146",false,"NCT07444840","How Does Pre-operative Biliary Drainage in Pancreatic Adenocarcinoma Affect Surgical Outcomes in Pancreatic Cancer Surgery","Pre-operative Biliary Drainage in Pancreatic Adenocarcinoma and Its Effect on Surgical Oncological Outcomes","PBDSOO","Inclusion Criteria:\n\n* Procedure - Pancreaticoduodenectomy\n* Histology - Pancreatic ductal adenocarcinoma at East Lancashire Hospitals NHS Trust\n* Age \\> 18 years\n\nExclusion Criteria:\n\nPatients \\\u003C 18 years of age Patients who had pancreaticoduodenectomy for benign disease Patients who had pancreaticoduodenectomy with any histology other than pancreatic ductal adenocarcinoma Patients who underwent any other procedure for head of pancreas pancreatic ductal adenocarcinoma Patients who have opted out from being part of research as per the MESH database","ALL","18 Years",{"count":48,"type":49},90,"ESTIMATED","OBSERVATIONAL","Pre-operative biliary drainage (PBD) is a procedure used to relieve bile duct obstruction, a common issue in patients with pancreatic cancer. The obstruction occurs when a tumor blocks the bile duct, leading to jaundice and other complications. While PBD can help resolve jaundice and improve liver function, its impact on the overall outcomes of pancreatic cancer surgery is still debated.\n\nRecent research has focused on whether PBD before surgery improves patient outcomes, such as surgical success, recovery time, and long-term survival. Some studies suggest that draining the bile before surgery might reduce complications like infections, liver dysfunction, and jaundice-related risks. On the other hand, other research indicates that PBD could increase the chances of infection, delays in surgery, or complications from the procedure itself, such as bile leakage or inflammation.\n\nThis study will look at patients undergoing pancreaticoduodenectomy to remove their head of pancreas pancreatic ductal adenocarcinoma over 8 years, and will compare the tumour characteristics of patients who have had PBD vs those who have not. Data will be gathered from the already available histological characteristics. No treatment would be affected and no tissue would be affected.\n\nThis research study will focus on oncological characteristics such as tumour progression and lymphatic spread, with overall patient survival as secondary outcome measures.",[53,54],"Pancreatic Ductal Adenocarcinoma (mPDAC)","Pancreatic Ductal Adenocarcinoma (PDAC)",[56,57,58,59,60,61],"pancreatic ductal adenocarcinoma","biliary drainage","oncology","T stage","perineural invasion","lymphovascular invasion","NOT_YET_RECRUITING","2026-02-25",{"date":65,"type":66},"2026-03-03","ACTUAL",{"date":68,"type":49},"2026-03-01",{"date":70,"type":49},"2026-05-01",{"name":5,"class":6}]