[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100403514":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":43,"responsibleParty":59,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":25,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"Children's Hospital of Fudan University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Early Mobilization Group (EM group)","EXPERIMENTAL","Early mobilization will be performed in this arm. Critically ill children will be assessed for appropriate activity within 24 hours of intubation. When the safe criteria is met, early mobilization goals will be set according to the children's clinical conditions, developmental maturity, strength and endurance. The detailed mobilization activities include bed repositioning，passive or active range of motion and stretching exercises, passive or active respiratory muscle strengthening, sitting in bed, transfer from lying to sitting at edge of bed. Progressive mobilization goals will be individualized for each subject daily.",[13],"Other: early mobilization",{"label":15,"type":16,"description":17,"interventionNames":18},"Routine Care Group (RC group)","ACTIVE_COMPARATOR","Routine care strategy without early mobilization will be performed in this arm. It includes the clinical status management, spontaneous breathing trials, choice of sedation and analgesia and routine nursing care including repositioning every 2 hours and bed head elevation.",[19],"Other: routine care",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"early mobilization","Early mobilization is a kind of rehabilitation strategy. When the safe standards are met, early mobilization will be performed on subjects randomized in EM group for 30 minutes each time, twice a day, from Monday to Friday. The detailed mobilization activities include bed repositioning，passive or active range of motion and stretching exercises, passive or active respiratory muscle strengthening, sitting in bed, transfer from lying to sitting at edge of bed. Progressive mobilization goals will be individualized for each subject daily, corresponding to their clinical conditions, developmental maturity, strength and endurance.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"routine care","In this arm, no additional early rehabilitation interventions will be performed except for the routine clinical care, including the ventilation management, spontaneous breathing trials, choice of sedation and analgesia and routine nursing care including repositioning every 2 hours and bed head elevation.",[15],[31],{"name":32,"affiliation":5,"role":33},"Liyuan Han","STUDY_DIRECTOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Sujuan Wang","CONTACT","86-13761000512","sujuanw@163.com",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"Yelin Yao","yelinyao@126.com",[44],{"facility":45,"status":46,"city":47,"state":25,"zip":25,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Children's Hospital, Fudan University","RECRUITING","Shanghai","China","CN",{"type":51,"coordinates":52},"Point",[53,54],121.45806,31.22222,{"lat":54,"lon":53},[57],{"name":58,"role":37,"phone":25,"phoneExt":25,"email":25},"Sujuan Wang, Dr.",{"type":60,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100403514","how-early-mobilization-impacts-on-diaphragm-thickness-in-critically-ill-children-100403514",false,"NCT04534296","How Early Mobilization Impacts on Diaphragm Thickness in Critically Ill Children","A Randomized Control Trial Comparing the Effects of Early Mobilization and Routine Care on Diaphragmatic Thickness","Inclusion Criteria:\n\n* subjects \\> 6 months and \\\u003C 12 years of age；\n* subjects been intubated and mechanically ventilated for \\\u003C 24 hours at the time of screening;\n* the Glasgow Coma Scale (GCS) on admission of Pediatric Intensive Care Unit (PICU) is greater than 3\n\nExclusion Criteria:\n\n* cardiopulmonary arrest;\n* history of diaphragmatic paralysis or neuromuscular disease;\n* neuromuscular blockade;\n* expectation to be liberated from ventilator in \\\u003C 24 hours\n* history of mechanical ventilation in the last 6 months\n* presence of tracheostomy\n* high cervical spine injury\n* status convulsion\n* thoracic trauma when ultrasonic examination cannot be performed","ALL","6 Months","12 Years",{"count":72,"type":73},160,"ESTIMATED","INTERVENTIONAL",[76],"NA","The objective is to compare the impact of early mobilization and routine care on diaphragm thickness in critically ill children",[79,80],"Mechanical Ventilation Complication","Ventilator-induced Diaphragm Dysfunction","2025-02-11",{"date":83,"type":84},"2025-02-12","ACTUAL",{"date":86,"type":84},"2021-04-26",{"date":88,"type":73},"2025-12",{"name":5,"class":6},1]