[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582243":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":21,"responsibleParty":37,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":10,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":23,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"University Hospital Schleswig-Holstein","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Lean individual with weight gain difficulties",null,"Participants in this group are lean individuals (BMI 18.5-22.0 kg\u002Fm²) who have difficulty gaining weight. They will undergo a 24-hour fasting period followed by a controlled low-protein, high-calorie meal test. Researchers will measure their resting metabolic rate before and after fasting, as well as the body's response to the test meal. By comparing these results to those of other groups, the study aims to identify metabolic factors that influence weight gain difficulties and guide future personalized treatments.",{"label":13,"type":10,"description":14,"interventionNames":10},"Individuals with obesity and weight loss difficulties","Participants in this group are individuals with obesity (BMI \\>30 kg\u002Fm²) who have difficulty losing weight. They will undergo a 24-hour fasting period followed by a controlled low-protein, high-calorie meal test. Researchers will measure their resting metabolic rate before and after fasting, as well as the body's response to the test meal. By comparing these findings with those of other groups, the study seeks to uncover metabolic factors that contribute to weight loss difficulties and guide more personalized treatment approaches.",[16],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},"Tim Hollstein, PD Dr. med.","CONTACT","+4943150022000","tim.hollstein@uksh.de",[22],{"facility":5,"status":23,"city":24,"state":25,"zip":26,"country":27,"countryCode":28,"cosmosGeoPoint":29,"geoPoint":34,"contacts":35},"RECRUITING","Kiel","Schleswig-Holstein","24105","Germany","DE",{"type":30,"coordinates":31},"Point",[32,33],10.13489,54.32133,{"lat":33,"lon":32},[36],{"name":17,"role":18,"phone":19,"phoneExt":10,"email":20},{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Tim Hollstein","Principal Investigator","100582243","how-metabolism-affects-weight-loss-and-gain-100582243",false,"NCT06860776","How Metabolism Affects Weight Loss and Gain","Pilot Study on the Analysis of the Metabolic Phenotype in Individuals With Difficulties in Losing and Gaining Weight","Inclusion Criteria:\n\n* Group 1 (Lean): BMI 18.5-22.0 kg\u002Fm², reporting difficulty gaining weight\n* Group 2 (Obese): BMI \\>30 kg\u002Fm², reporting difficulty losing weight\n* Healthy status as determined by medical history, physical examination, and laboratory tests\n* Stable weight (less than 5% fluctuation) over the past 6 months\n\nExclusion Criteria:\n\n* Prediabetes (HbA1c \\>5.6% or fasting blood glucose \\>100 mg\u002FdL) or diabetes mellitus\n* Conditions affecting appetite or energy expenditure (e.g., Cushing's syndrome, uncontrolled hyper-\u002Fhypothyroidism)\n* Gastrointestinal disorders that impact nutrient absorption (e.g., inflammatory bowel disease, malabsorption syndromes, ulcers)\n* Psychiatric conditions influencing eating behavior (e.g., active depression, anorexia nervosa, bulimia nervosa, borderline personality disorder)\n* Acute, unstable cardiovascular disease requiring hospitalization within the last 6 months (e.g., stent placement)\n* Cancer that required treatment in the past 5 years\n* Chronic kidney disease (Stage IV or higher, per NKF criteria)\n* Active infectious disease (e.g., HIV, hepatitis)\n* Current nicotine use or nicotine use within the last month prior to screening\n* Illicit drug use (e.g., amphetamines, cocaine, heroin, marijuana)\n* Regular high-intensity physical activity (≥1 hour\u002Fday)\n* Non-MRI-compatible metallic implants (e.g., artificial joints, metal plates)\n* Pregnancy or breastfeeding\n* Use of weight-loss medications\n* Clinically significant claustrophobia\n* Any other condition not mentioned above that, in the opinion of the investigator, could interfere with study participation or compromise patient safety",true,"ALL","18 Years","70 Years",{"count":53,"type":54},20,"ESTIMATED","OBSERVATIONAL","This study examines why some individuals with obesity have difficulty losing weight, whereas some lean individuals struggle to gain weight. The investigators will measure how the human body uses energy during a fasting period and after consumption of a specially designed, low-protein meal. By comparing these responses, the investigators aim to identify different \"metabolic phenotypes\" that affect weight control. Findings from this research may lead to more personalized treatments for managing weight. Participation in this study involves simple tests and basic body measurements.",[58],"Obesity and Overweight",[60,61,62,63,64,65,66],"obesity","metabolic phenotype","thrifty","spendthrift","diet-induced thermogenesis","fasting","indirect calorimetry","2025-03-07",{"date":69,"type":70},"2025-03-12","ACTUAL",{"date":72,"type":70},"2024-09-16",{"date":74,"type":54},"2025-08-01",{"name":5,"class":6},1]