[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621643":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":45,"collaborators":10,"id":48,"slug":49,"hasResults":50,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":50,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},{"fullName":5,"class":6},"University of Modena and Reggio Emilia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cases",null,"Patients undergoing surgical lung biopsy\u002Fcriobiopsy for clinical purpose in the diagnostic work-up of ILD.",[13],"Procedure: Biopsy",{"label":15,"type":10,"description":16,"interventionNames":17},"Controls","Patients undergoing lung lobectomy for lung cancer suspicion.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","Biopsy","This is a non-therapeutic, observational sampling study. Procedures include:\n\nLung tissue sampling via:\n\nSurgical biopsy Transbronchial cryobiopsy Explanted lungs from transplant patients Blood sampling for exosome analysis",[9,15],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Roberto Tonelli","CONTACT","+390594225934","rtonelli@unimore.it",[31],{"facility":32,"status":33,"city":34,"state":10,"zip":10,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"Azienda Ospedaliero Universitaria Policlinico di Modena","RECRUITING","Modena","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],10.92539,44.64783,{"lat":41,"lon":40},[44],{"name":26,"role":27,"phone":10,"phoneExt":10,"email":10},{"type":46,"investigatorFullName":26,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Principal investigator","100621643","hoxb7-and-linked-tissue-and-blood-biomarkers-in-the-lungs-of-patients-with-pulmonary-fibrosis-100621643",false,"NCT07373288","HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis","HOGWARTS","Inclusion Criteria:\n\n* Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis\n* Availability of fresh lung tissue from biopsy or lung explant\n* Signed informed consent for research use of biological material and data\n\nExclusion Criteria:\n\n\\- Refusal to sign informed consent","ALL","18 Years","80 Years",{"count":59,"type":60},80,"ESTIMATED","OBSERVATIONAL","This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.",[64],"Fibrosis, Pulmonary",[66,67,68,69],"Idiopathic pulmonary fiborsis","Criobiopsy","Lung proteomic","Lung transcriptomic","2026-02-03",{"date":72,"type":73},"2026-02-04","ACTUAL",{"date":75,"type":73},"2023-07-01",{"date":77,"type":60},"2030-07-01",{"name":5,"class":6},1]