[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100565449":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":28,"centralContacts":33,"locations":42,"responsibleParty":64,"collaborators":10,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":10,"enrollmentInfo":78,"targetDuration":10,"studyType":81,"phases":10,"briefSummary":82,"conditions":83,"keywords":10,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"HPV Positive HNSCC Population",null,"Tissues from Head Neck Squamous Cell Carcinoma and HPV DNA-positive",[13],"Diagnostic Test: Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing",{"label":15,"type":10,"description":16,"interventionNames":17},"HPV Negative HNSCC Population","Tissues from Head Neck Squamous Cell Carcinoma and HPV DNA-negative",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Healthy Population","Healthy Population who does not have any carcinoma, chronic diseases, Genetic diseases, acute\u002Fchronic infectious diseases, etc.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"DIAGNOSTIC_TEST","Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing","Histopathology for carcinoma detection, Immunohistochemistry for carcinoma-related protein expression, Real-Time PCR for HPV association and HPV typing, Sequencing for genetic study or mutation analysis.",[15,9,19],[29],{"name":30,"affiliation":31,"role":32},"S M Rashed Ul Islam, M. Phil, MPH","Bangabandhu Sheikh Mujib Medical University (BSMMU)","PRINCIPAL_INVESTIGATOR",[34,38],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},"CONTACT","+8801713236399","smrashed@bsmmu.edu.bd",{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},"Syed Farhan Ali Razib, FCPS","+8801714043556","razib10@bsmmu.edu.bd",[43],{"facility":31,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"RECRUITING","Dhaka","Dhaka Division","1000","Bangladesh","BD",{"type":51,"coordinates":52},"Point",[53,54],90.40744,23.7104,{"lat":54,"lon":53},[57,58,59,60,62],{"name":30,"role":35,"phone":36,"phoneExt":10,"email":37},{"name":39,"role":35,"phone":40,"phoneExt":10,"email":41},{"name":39,"role":35,"phone":10,"phoneExt":10,"email":10},{"name":61,"role":35,"phone":10,"phoneExt":10,"email":10},"Bishnu Pada Dey, MD",{"name":63,"role":35,"phone":10,"phoneExt":10,"email":10},"Afzalun Nessa, M. Phil",{"type":32,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"S M Rashed Ul Islam","Associate Professor","100565449","human-papillomavirus-association-and-genomic-exploration-in-head-neck-squamous-cell-carcinomas-100565449",false,"NCT06642324","Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas","Exploration of Human Papillomavirus Association and Genomic Characteristics in Head and Neck Squamous Cell Carcinomas in Bangladesh","HPV & HNSCC","Inclusion Criteria:\n\n1. Patient Age: adult (\\> 18 years)\n2. Head and neck squamous cell carcinoma diagnosed by biopsy (Histopathology confirmed HNSCC).\n3. Diagnosed cases specific Head-Neck sub-sites: (oral cavity, oropharynx, hypopharynx, larynx, tongue)\n4. Patient's Consent\n\nExclusion Criteria:\n\n1. Patient Age: children (\\\u003C 18 years)\n2. Cancers of any part of the body other than the head-neck region.\n3. People without HNSCC\n4. Any chronic diseases, genetic diseases, acute\u002Fchronic infectious diseases, etc. -",true,"ALL","18 Years",{"count":79,"type":80},550,"ESTIMATED","OBSERVATIONAL","Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main goal of this observational study is to explore the prevalence, risk factors, and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy. This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population, identify risk factors, and any biologically driven mechanisms causing HNSCC.",[84,85],"Head Neck Cancer","Oropharyngeal Neoplasms","2024-12-28",{"date":88,"type":89},"2024-12-31","ACTUAL",{"date":91,"type":89},"2024-04-30",{"date":93,"type":80},"2025-09-30",{"name":5,"class":6},1]