[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606653":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":48,"collaborators":53,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":52,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":34,"whyStopped":52,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Queen's University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental: Bedrest","EXPERIMENTAL","19 day study period, consisting of baseline testing, 5 days of free-living (habitual daily activities) immediately followed by 5 days of strict bedrest. Diet controlled and physical activity monitored for entire study period.",[13],"Other: Bedrest",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Bedrest","5 days of strict bedrest. Participants are allowed to sit up in bed, but will perform any bathing or bathroom activities in a wheelchair.",[9],[20],"Horizontal Bedrest",[22],{"name":23,"affiliation":5,"role":24},"Chris McGlory, PhD.","PRINCIPAL_INVESTIGATOR",[26],{"name":23,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","6135336000","75410","chris.mcglory@queensu.ca",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"Queen's Univeristy","RECRUITING","Kingston","Ontario","K7L 3N6","Canada","CA",{"type":41,"coordinates":42},"Point",[43,44],-76.48098,44.22976,{"lat":44,"lon":43},[47],{"name":23,"role":27,"phone":28,"phoneExt":29,"email":30},{"type":24,"investigatorFullName":49,"investigatorTitle":50,"investigatorAffiliation":51,"oldNameTitle":52,"oldOrganization":52},"Dr. Chris McGlory, PhD","Associate Professor","Kingston Health Sciences Centre",null,[54],{"name":55,"class":56},"Canadian Institutes of Health Research (CIHR)","OTHER_GOV","100606653","human-skeletal-muscle-response-to-5-days-of-bedrest-in-young-adults-100606653",false,"NCT07178353","Human Skeletal Muscle Response to 5 Days of Bedrest in Young Adults","Changes in Muscle Mass, Strength, and Muscle Protein Synthesis in Response to 5 Days of Bedrest in Young, Healthy Adults","FABRIC","Inclusion Criteria:\n\n* Males and females 18-30 years\n* BMI between 18.5-28 kg\u002Fm2\n* Weight stable (within ±2kg for 6 months)\n* Generally healthy as assessed by medical and physical activity questionnaires\n* recreationally active\n\nExclusion Criteria:\n\n* a BMI \\\u003C 18.5 and \\> 28 kg\u002Fm2\n* the use of insulin to control blood glucose levels\n* a history of any cardiovascular, respiratory, metabolic diseases, neuromuscular or bone-wasting diseases\n* the use of any medication that may affect muscle protein turnover (e.g. androgen or anabolic hormone therapy, chemotherapy)\n* a (family) history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy and the use of anticoagulant medications\n* the presence of any unremoved, or partially removed metals underneath the skin\n* a history of head or eye injury involving metal fragments\n* have some type of implanted electrical device (such as a cardiac pacemaker or neurostimulator)\n* have implanted metal objects as a result of surgery, such as artificial joints, aneurysm clips, metal staples\n* are, or may be, pregnant\n* are wearing metal braces on their teeth.",true,"ALL","18 Years","30 Years",{"count":70,"type":71},12,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this intervention trial is to characterize skeletal muscle atrophy in healthy, young adults during short term bedrest. The main questions it aims to answer are:\n\nHow much do skeletal muscle volume, strength, and fatigue resistance decline during bedrest? How much does whole-body insulin sensitivity change during bedrest? How do mitochondrial function and protein synthesis change during bedrest?\n\nParticipants will undergo the following tests before and after a free-living control period and before and after a 5 day period of strict horizontal bedrest:\n\n* Magnetic resonance imaging of the thigh muscles\n* Strength testing of the thigh muscles\n* Insulin sensitivity testing in response to a mixed meal\n* Exogenous glucose oxidation in response to a mixed meal\n* Muscle biopsies from the thigh muscles\n* Blood samples",[77,78,79],"Muscular Atrophy","Insulin Resistance","Muscle Protein Synthesis",[81,82,83,84,85,86],"magnetic resonance imaging","muscle protein syntheis","muscle disuse atrophy","bedrest","skeletal muscle","insulin sensitivity","2025-09-16",{"date":89,"type":90},"2025-09-22","ACTUAL",{"date":92,"type":71},"2025-09",{"date":94,"type":71},"2027-06",{"name":5,"class":6},1]