[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591751":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":37,"locations":45,"responsibleParty":62,"collaborators":24,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":24,"eligibilityCriteria":71,"healthyVolunteers":67,"sex":72,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":24,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":89,"whyStopped":24,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"General Hospital of Shenyang Military Region","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Peripheral veins infusion group","EXPERIMENTAL","Peripheral veins infusion of stem cells",[13],"Other: Infusion of umbilical cord-mesenchymal stem cells through peripheral veins",{"label":15,"type":10,"description":16,"interventionNames":17},"Hepatic arterial infusion group","Hepatic arterial infusion of stem cells",[18],"Other: Infusion of umbilical cord-mesenchymal stem cells through hepatic artery",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Infusion of umbilical cord-mesenchymal stem cells through peripheral veins","Umbilical cord-mesenchymal stem cells injected through peripheral veins",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Infusion of umbilical cord-mesenchymal stem cells through hepatic artery","Umbilical cord-mesenchymal stem cells injected through hepatic artery",[15],[30,34],{"name":31,"affiliation":32,"role":33},"Xingshun Qi, MD","The General Hospital of Northern Theater Command Study Director","STUDY_DIRECTOR",{"name":35,"affiliation":32,"role":36},"Beilei Zhang, MM","PRINCIPAL_INVESTIGATOR",[38,42],{"name":31,"role":39,"phone":40,"phoneExt":24,"email":41},"CONTACT","18909881019","xingshunqi@126.com",{"name":35,"role":39,"phone":43,"phoneExt":24,"email":44},"15191080726","15191080726@163.com",[46],{"facility":47,"status":24,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"General Hospital of Northern Theater Command Recruiting","Shenyang","Liaoning","110840","China","CN",{"type":54,"coordinates":55},"Point",[56,57],123.43278,41.79222,{"lat":57,"lon":56},[60,61],{"name":31,"role":39,"phone":40,"phoneExt":24,"email":41},{"name":35,"role":39,"phone":43,"phoneExt":24,"email":44},{"type":36,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Xingshun Qi","Director of Department of Gastroenterology","100591751","human-umbilical-cord-mesenchymal-stem-cells-via-different-transplantation-routes-in-esld-100591751",false,"NCT06984497","Human Umbilical Cord-mesenchymal Stem Cells Via Different Transplantation Routes in ESLD","Efficacy and Safety of Different Transplantation Routes of Human Umbilical Cord-mesenchymal Stem Cells in Patients With End-stage Liver Disease","Inclusion Criteria:\n\n1. 18-80 years old\n\n   \\-\n2. End-stage liver disease\n\n   \\-\n3. Signed informed consent\n\nExclusion Criteria:\n\n1. Tumours of the liver or other organs\n\n   \\-\n2. Liver transplantation recipients\n\n   \\-\n3. Acute myocardial infarction, acute heart failure, type I and type II respiratory failure, pulmonary embolism, acute cerebral infarction, acute cerebral haemorrhage and other serious cardiopulmonary diseases\n\n   \\-\n4. Other diseases that may seriously affect the survival\n\n   \\-\n5. Human immunodeficiency syndrome\n\n   \\-\n6. Interferon or glucocorticoid therapy within 1 year\n\n   \\-\n7. Treated for mental illness\n\n   \\-\n8. Participation in other clinical trials within 30 days\n\n   \\-\n9. Pregnant or breastfeeding subjects\n\n   \\-\n10. Allergic asthma, allergic urticaria, eczema, or a history of multiple drug and food allergies\n\n    \\-\n11. Other circumstances that are unsuitable for participation in this study","ALL","18 Years","80 Years",{"count":76,"type":77},32,"ESTIMATED","INTERVENTIONAL",[80],"NA","Stem cells are non-terminal cells that can self renew and replicate through symmetric or asymmetric division, with the potential to differentiate into different types of cells and tissues. Multiple studies have shown that human umbilical cord mesenchymal stem cell has good safety and effectiveness in improving acute or chronic liver injury.\n\nStem cell therapy for end-stage liver disease (ESLD) can be administered through various routes, among which hepatic artery and peripheral vein infusions are the most commonly used in clinical practice. The efficacy of hepatic artery infusion appears to be greater than that of peripheral vein infusion.",[83],"End-Stage Liver Diseases",[85,86,87,88],"cirrhosis","end-stage liver diseases","umbilical cord-mesenchymal stem cells","randomized controlled trial","NOT_YET_RECRUITING","2025-08-22",{"date":92,"type":93},"2025-08-24","ACTUAL",{"date":95,"type":77},"2025-09",{"date":97,"type":77},"2027-12",{"name":5,"class":6},1]