[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100539890":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":70,"collaborators":72,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":25,"eligibilityCriteria":82,"healthyVolunteers":78,"sex":83,"minAge":84,"maxAge":25,"enrollmentInfo":85,"targetDuration":25,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":25,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Queen Mary University of London","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Test","EXPERIMENTAL","Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA)",[13],"Combination Product: Periodontal Access Flap (AF) + Combined Formulation of Hyaluronic acid and Polydeoxyribonucleotides (PNHA)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","ACTIVE_COMPARATOR","Periodontal Access Flap (AF)",[19],"Procedure: Periodontal Access Flap (AF)",[21,26],{"type":22,"name":11,"description":23,"armGroupLabels":24,"otherNames":25},"COMBINATION_PRODUCT","A conservative access flap will be performed such as simplified papilla preservation flap (SPPF). A PNHA gel will be placed on the root surfaces and supra-bony defects, followed by a tension-free primary closure of the interdental papillae and of the mucoperiosteal flaps by means of 5-0 suture",[9],null,{"type":27,"name":17,"description":28,"armGroupLabels":29,"otherNames":25},"PROCEDURE","A conservative access flap will be performed such as simplified papilla preservation flap (SPPF). No gel will be placed before suturing the flap by tension-free primary closure of the interdental papillae and of the mucoperiosteal flaps by means of 5-0 suture",[15],[31],{"name":32,"affiliation":33,"role":34},"Elena Calciolari, DDS, MS, PhD","QMUL","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Miljana Bacevic","CONTACT","+442078823063","BHNT.Clinicaloralresearchcentre@nhs.net",{"name":32,"role":38,"phone":39,"phoneExt":25,"email":42},"e.calciolari@qmul.ac.uk",[44,61],{"facility":45,"status":46,"city":47,"state":25,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Barts Health NHS Trust Dental Hospital","RECRUITING","London","E1 1BB","United Kingdom","UK",{"type":52,"coordinates":53},"Point",[54,55],-0.12574,51.50853,{"lat":55,"lon":54},[58,60],{"name":37,"role":38,"phone":59,"phoneExt":25,"email":40},"+44(0)207 882 6348",{"name":32,"role":38,"phone":25,"phoneExt":25,"email":42},{"facility":62,"status":46,"city":47,"state":25,"zip":63,"country":49,"countryCode":50,"cosmosGeoPoint":64,"geoPoint":66,"contacts":67},"Centre for Oral Clinical Research (COCR)","E1 2AD",{"type":52,"coordinates":65},[54,55],{"lat":55,"lon":54},[68,69],{"name":37,"role":38,"phone":59,"phoneExt":25,"email":40},{"name":32,"role":38,"phone":25,"phoneExt":25,"email":42},{"type":71,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR",[73],{"name":74,"class":75},"Geistlich Pharma AG","INDUSTRY","100539890","hyaluronic-acid-and-polynucleotides-for-supra-bony-defects-100539890",false,"NCT06309719","Hyaluronic Acid and Polynucleotides for Supra-bony Defects","Characterizing the Healing of Periodontal Supra-bony Defects Treated With Hyaluronic Acid and Polynucleotides","Inclusion Criteria:\n\n* Systemically healthy males and females ≥18 years old\n* Stage III or IV periodontitis (Papapanou, Sanz et al. 2018)\n* Presence of supra-bony periodontal defects (i.e., defects where the base of the pocket is located coronal to the alveolar crest and characterized by a predominantly horizontal pattern of tissue destruction) confirmed clinically and radiographically at a minimum of two and a maximum of four adjacent teeth and with a probing pocket depth (PPD) \\> 5 mm, following non-surgical periodontal therapy (NSPT). If \\>4 adjacent teeth exhibited the above clinical and radiographic conditions, the four adjacent teeth showing the greatest overall loss of periodontal attachment were included. Wisdom teeth and second molars will not be considered for the study.\n\nIf defect presents with an intrabony component, this should be ≤2 mm.\n\n* Non-surgical periodontal treatment (step 1 and 2) completed within the previous 4 months\n* Full-mouth bleeding score (FMBS) and full-mouth plaque score (FMPS) ≤20%\n\nExclusion Criteria:\n\n* Teeth with degree III mobility\n* Multi-rooted teeth with grade ≥2 furcation involvement\n* Heavy smokers (≥10 cigarettes a day)\n* Untreated caries or endodontic lesions or abscesses on the teeth involved in the surgery\n* Previous periodontal surgery in the area selected for the study\n* History of conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures (e.g., mitral valve prolapse, artificial heart)\n* Antibiotic or anticoagulant therapy during the month preceding the baseline exam.\n* History of alcohol or drug abuse\n* Medical history that includes uncontrolled diabetes or hepatic or renal diseases, or other serious medical conditions that can have a negative impact on the periodontal condition\n* In treatment with medications that can severely affect bone metabolism and blood clot formation (e.g., anticoagulants, long-term corticosteroids, bisphosphonates, immunosuppressants)\n* Self-reported pregnancy or lactation.","ALL","18 Years",{"count":86,"type":87},24,"ESTIMATED","INTERVENTIONAL",[90],"NA","The goal of this pilot study is to describe the early wound healing molecular events and the vascularization pattern associated with the treatment of supra-bony defects with access flap alone or in association with a combined formulation of hyaluronic acid and polydeoxyribonucleotides gel.",[93,94,95,96,97],"Periodontal Diseases","Wound Heal","Periodontal Inflammation","Periodontal Pocket","Periodontal Attachment Loss","2026-07-01",{"date":100,"type":101},"2026-07-02","ACTUAL",{"date":103,"type":101},"2024-10-21",{"date":105,"type":87},"2026-12",{"name":5,"class":6},2]