[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637782":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":48,"collaborators":51,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":78,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"The First Hospital of Jilin University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Surgical group",null,"The group of patients underwent surgical resection treatment.",[13],"Procedure: surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"Microwave Ablation Group","The group of patients underwent microwave ablation treatment.",[18],"Procedure: ablation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","surgery","The surgery was performed in supine position under general anesthesia with open\u002Flaparoscopic liver resection (LH), and the main and secondary incisions were made based on the tumor location. Intraoperative ultrasound was routinely used to assess the tumor, remnant liver volume, and the feasibility of negative margins. The type of liver resection followed established guidelines.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"ablation","Ablation is performed under ultrasound guidance and intravenous anesthesia, using the KY-2000 treatment device with disposable ablation needles and monitoring software. For tumors with a diameter of less than 2cm, a single needle is used; for tumors of 2cm or more, dual needles (needle spacing ≤ 2cm) are used. The ablation parameters are set to a power of 40-65W and a duration of 1-15 minutes, with immediate post-operative ultrasound (contrast) assessment of the ablation range.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Dezhi Zhang","CONTACT","+8618186876068","dezhi@ilu.edu.cn",[36],{"facility":37,"status":10,"city":38,"state":39,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":10},"The First Hospital of jilin University","Changchun","Jilin","China","CN",{"type":43,"coordinates":44},"Point",[45,46],125.32278,43.88,{"lat":46,"lon":45},{"type":49,"investigatorFullName":31,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Principal Investigator",[52],{"name":53,"class":6},"Chinese PLA General Hospital","100637782","hybrid-deep-learning-integrating-multimodal-ceus-and-enhanced-mri-to-optimize-early-stage-hcc-treatment-decisions-100637782",false,"NCT07582419","Hybrid Deep Learning Integrating Multimodal CEUS and Enhanced MRI to Optimize Early-Stage HCC Treatment Decisions","Hybrid Deep Learning Models Based on Multimodal CEUS and Enhanced MRI Can Optimize Treatment Decisions for Early-stage Hepatocellular Carcinoma","HDL-CEUS-MRI","Inclusion Criteria:\n\n1. Preoperative enhanced imaging examination or pathological diagnosis is HCC;\n2. CNLC Stage I, IIa, Child-Pugh Class A\u002FB;\n3. A single tumor with a diameter ≤ 5 cm or 2-3 tumors, with the maximum diameter ≤ 3 cm;\n4. Perform liver resection surgery or MWA surgery treatment;\n5. MRI and\u002For CEUS examinations performed within one month before surgery\n\nExclusion Criteria:\n\n1：There is already extrahepatic metastasis or the presence of other malignant tumors;\n\n2: History of other treatments prior to surgery;\n\n3: Incomplete preoperative ultrasound contrast and\u002For MRI imaging data, with images missing or unclear;\n\n4: Missing postoperative follow-up data","ALL","18 Years","85 Years",{"count":66,"type":67},1424,"ESTIMATED","OBSERVATIONAL","This study aims to address the issue of a lack of individualized basis for selecting liver resection (LH) or microwave ablation (MWA) in early-stage hepatocellular carcinoma (HCC) patients to reduce the early recurrence rate (≤2 years). Given that existing machine learning-based recurrence prediction studies have failed to guide the optimal treatment plan selection, and that multidisciplinary consultations rely on guidelines (universality) and experience (subjectivity) which have their limitations, we propose to utilize artificial intelligence (AI), specifically the advantages of multimodal deep learning technology (which outperforms traditional machine learning by integrating complementary information to provide more accurate predictions), to establish a hybrid deep learning model that integrates contrast-enhanced ultrasound (CEUS) and enhanced magnetic resonance imaging (MRI) features. This model will predict the probability of early recurrence (ER≤2 years) in patients and, based on this, recommend LH or MWA as the optimal first treatment option for newly diagnosed early HCC patients to optimize individualized treatment decisions.",[71],"Hepatocellular Carcinoma (HCC)",[73,74,75,76,77],"Multimodal","CEUS","Enhanced MRI","Treatment Decisions","hepatocellular carcinoma","NOT_YET_RECRUITING","2026-05-07",{"date":81,"type":82},"2026-05-12","ACTUAL",{"date":84,"type":67},"2026-04-30",{"date":86,"type":67},"2027-10-30",{"name":5,"class":6},1]