[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602940":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":32,"centralContacts":37,"locations":47,"responsibleParty":62,"collaborators":42,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":42,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":42,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":88,"whyStopped":42,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Malaya","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Hybrid Endurance and Strength Training (HybEST)","EXPERIMENTAL","HybEST will be delivered three times weekly over eight weeks; there will be two supervised sessions at the center and 22 unsupervised sessions at home.",[13],"Other: Hybrid Endurance Strength Training",{"label":15,"type":16,"description":17,"interventionNames":18},"Usual Care (UC)","ACTIVE_COMPARATOR","The UC group participants will participate in combined endurance and strength training similar to the intervention group's weekly center-based session over eight weeks.",[19],"Other: Usual Care",[21,27],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Hybrid Endurance Strength Training","HybEST will be delivered three times weekly over eight weeks, with two supervised sessions at the center and 22 unsupervised sessions at home. The exercise characteristics of supervised HybEST and unsupervised HybEST are described. Monitoring methods for unsupervised HybEST include a wearable tracking device that collects data on patients' health parameters (arterial oxygen saturation (SpO2), heart rate, and blood pressure) and weekly phone calls. The unsupervised sessions will include video material on the home-based exercise program.",[9],[26],"HyBEST",{"type":6,"name":28,"description":17,"armGroupLabels":29,"otherNames":30},"Usual Care",[15],[31],"UC",[33],{"name":34,"affiliation":35,"role":36},"Anwar Suhaimi","Universiti Malaya Medical Center","PRINCIPAL_INVESTIGATOR",[38,44],{"name":39,"role":40,"phone":41,"phoneExt":42,"email":43},"Aliff Latir","CONTACT","+60183544770",null,"aliff533@uitm.edu.my",{"name":34,"role":40,"phone":45,"phoneExt":42,"email":46},"+60166591383","anwar@ummc.edu.my",[48],{"facility":35,"status":42,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Kuala Lumpur","Lembah Pantai","59100","Malaysia","MY",{"type":55,"coordinates":56},"Point",[57,58],101.68653,3.1412,{"lat":58,"lon":57},[61],{"name":34,"role":40,"phone":45,"phoneExt":42,"email":46},{"type":63,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR","100602940","hybrid-exercise-program-for-heart-disease-effect-on-health-and-quality-of-life-100602940",false,"NCT07130045","Hybrid Exercise Program for Heart Disease: Effect on Health and Quality of Life","Effect of Hybrid Endurance and Strength Training (HyBEST) on Health-Related Outcomes and Quality of Life in Patients With Coronary Artery Disease During Phase II Cardiac Rehabilitation Program","Inclusion Criteria:\n\n* Age of 18 years or older.\n* Diagnosed with coronary artery disease (CAD), with or without invasive treatment, maintaining a normal sinus rhythm and preserved left ventricular ejection fraction (LVEF).\n* In a stable clinical condition.\n* capable of regularly attending a supervised exercise program.\n* Able to complete questionnaires in English or Malay.\n\nExclusion Criteria:\n\n* They exhibited abnormal responses during the initial exercise test, such as irregular haemodynamic responses, ST segment depression greater than 2 mm, or any ventricular fibrillation.\n* Their forced expiratory volume in 1 second (FEV1) or forced vital capacity (FVC) is less than 50% of the predicted value.\n* They cannot participate in exercise testing due to non-cardiac limitations.\n* They have been hospitalized due to heart failure within the past year.\n* They have uncontrollable hypertension.","ALL","18 Years","75 Years",{"count":75,"type":76},84,"ESTIMATED","INTERVENTIONAL",[79],"NA","Cardiac rehabilitation (CR) participation remains suboptimal, partly due to logistical challenges and limited access to center-based programs. Hybrid Endurance-Strength Training (HybEST) offers an alternative model by combining supervised endurance and strength exercises with home-based components. The main questions it aims to answer are:\n\n* Does a hybrid exercise program significantly improve a patient's body function and structures \\[exercise capacity, body composition, and muscle strength\\] compared to usual care?\n* Does a hybrid exercise program significantly improve a patient's activity \\[functional capacity, physical activity, and total energy expenditure\\] compared to usual care?\n* Does a hybrid exercise program significantly improve a patient's participation \\[health-related quality of life\\] compared to usual care?\n\nThis single-center, two-arm parallel randomized clinical trial aims to evaluate the effects of HybEST on health-related outcomes and quality of life among patients with coronary artery disease in Phase II CR. Eligible participants will be randomly assigned in a 1:1 ratio to either the HybEST intervention group or the standard CR control group using a lottery method, specifically the sealed envelope approach. Assessments will be conducted at baseline (T0), Week 5 (T2), and Week 9 (T3) to measure changes in health-related outcomes and quality of life.",[82],"Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))",[84,85,86,87],"coronary artery disease","combined training","hybrid","cardiac rehabilitation","NOT_YET_RECRUITING","2026-04-13",{"date":91,"type":92},"2026-04-17","ACTUAL",{"date":94,"type":76},"2026-10",{"date":96,"type":76},"2027-12",{"name":5,"class":6},1]