[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100610919":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":37,"centralContacts":41,"locations":49,"responsibleParty":215,"collaborators":217,"id":224,"slug":225,"hasResults":226,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":230,"eligibilityCriteria":231,"healthyVolunteers":226,"sex":232,"minAge":233,"maxAge":23,"enrollmentInfo":234,"targetDuration":23,"studyType":237,"phases":238,"briefSummary":240,"conditions":241,"keywords":247,"overallStatus":52,"whyStopped":23,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":262,"locationsCount":263},{"fullName":5,"class":6},"Hospital Israelita Albert Einstein","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Surface disinfection with aerosolized hydrogen peroxide","EXPERIMENTAL","The hygiene team of each participating ICU will spray aerosolized peroxide hydrogen using a specific device when performing terminal cleaning of the ICU bed after the patient's discharge. As peroxide hydrogen aerosol can be irritating to people nearby, we will use a tent designed to cover the bed and nearby equipment during peroxide hydrogen disinfection, thus preventing aerosols from spreading to other beds and other areas of ICUs where beds are not in closed rooms.",[13],"Other: Aerosol of hydrogen peroxide",{"label":15,"type":10,"description":16,"interventionNames":17},"Surface disinfection with irradiation of ultraviolet light","The hygiene team of each participating ICU will use a specific device, requiring no manipulation, for irradiating UV light for the purpose of disinfecting beds and surfaces near beds during terminal cleaning. To prevent UV irradiation from reaching occupied beds and other areas of the ICU, the same tent described in the \"peroxide hydrogen\" arm.",[18],"Other: Irradiation of ultraviolet light",{"label":20,"type":21,"description":22,"interventionNames":23},"Usual disinfection","NO_INTERVENTION","The control group will perform standard cleaning and disinfection of the beds and the environment according to their previous protocols, using the usual products.",null,[25,31],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"Aerosol of hydrogen peroxide","Spray of aerosolized peroxide hydrogen using a specific device when performing terminal cleaning of the ICU bed after the patient's discharge.",[9],[30],"Hydrogen Peroxide",{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Irradiation of ultraviolet light","Irradiation of UV light for the purpose of disinfecting beds and surfaces near beds during terminal cleaning.",[15],[36],"Ultraviolet light",[38],{"name":39,"affiliation":5,"role":40},"Antonio P Nassar Jr, PhD","PRINCIPAL_INVESTIGATOR",[42,46],{"name":39,"role":43,"phone":44,"phoneExt":23,"email":45},"CONTACT","551121519617","antonio.nassar@einstein.br",{"name":47,"role":43,"phone":44,"phoneExt":23,"email":48},"Adriano J Pereira, PhD","Adriano.Pereira2@einstein.br",[50,68,82,95,109,122,136,150,164,178,191,205],{"facility":51,"status":52,"city":53,"state":54,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Hospital Maternidade Sao Vicente De Paulo","RECRUITING","Barbalha","Ceará","Brazil","BR",{"type":58,"coordinates":59},"Point",[60,61],-39.30417,-7.31111,{"lat":61,"lon":60},[64],{"name":65,"role":43,"phone":66,"phoneExt":23,"email":67},"Meton S Alencar Filho","55-85-3532-7100","meton.filho@icloud.com",{"facility":69,"status":52,"city":70,"state":71,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":72,"geoPoint":76,"contacts":77},"Instituto Hospital de Base","Brasília","Federal District",{"type":58,"coordinates":73},[74,75],-47.92972,-15.77972,{"lat":75,"lon":74},[78],{"name":79,"role":43,"phone":80,"phoneExt":23,"email":81},"Glecia C Rocha","55-61-3550-8900","gleciacarla@yahoo.com.br",{"facility":83,"status":52,"city":84,"state":85,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":86,"geoPoint":90,"contacts":91},"Hospital Estadual de Aparecida de Goiânia","Aparecida de Goiânia","Goiás",{"type":58,"coordinates":87},[88,89],-49.24389,-16.82333,{"lat":89,"lon":88},[92],{"name":93,"role":43,"phone":94,"phoneExt":23,"email":23},"Wallef S Rodrigues","55-62-3983-1750",{"facility":96,"status":52,"city":97,"state":98,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Santa Casa de Misericórdia de Passos","Passos","Minas Gerais",{"type":58,"coordinates":100},[101,102],-46.60972,-20.71889,{"lat":102,"lon":101},[105],{"name":106,"role":43,"phone":107,"phoneExt":23,"email":108},"Priscila F Gonçalves","88-35-3529-1300","ccih.coordenacao@scpassos.org.br",{"facility":110,"status":52,"city":111,"state":112,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Fundo Municipal de Saúde de Maringá","Maringá","Paraná",{"type":58,"coordinates":114},[115,116],-51.93861,-23.42528,{"lat":116,"lon":115},[119],{"name":120,"role":43,"phone":121,"phoneExt":23,"email":23},"Francielle C Pereira","55-44-3127-3100",{"facility":123,"status":52,"city":124,"state":125,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Hospital da Restauração","Recife","Pernambuco",{"type":58,"coordinates":127},[128,129],-34.88111,-8.05389,{"lat":129,"lon":128},[132],{"name":133,"role":43,"phone":134,"phoneExt":23,"email":135},"Debora M Pinho","55-81-3181-5400","debypinho61@gmail.com",{"facility":137,"status":52,"city":138,"state":139,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":140,"geoPoint":144,"contacts":145},"Hospital Universitário da Universidade Federal do Piauí","Teresina","Piauí",{"type":58,"coordinates":141},[142,143],-42.80194,-5.08917,{"lat":143,"lon":142},[146],{"name":147,"role":43,"phone":148,"phoneExt":23,"email":149},"Rejane M Prestes","55-86-3228-5201","prestesrejane@gmail.com",{"facility":151,"status":52,"city":152,"state":153,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":154,"geoPoint":158,"contacts":159},"Hospital Universitário Onofre Lopes","Natal","Rio Grande do Norte",{"type":58,"coordinates":155},[156,157],-35.20944,-5.795,{"lat":157,"lon":156},[160],{"name":161,"role":43,"phone":162,"phoneExt":23,"email":163},"Eliane P da Silva","55-84-3342-5000","eliane.psilva@esberh.gov.br",{"facility":165,"status":52,"city":166,"state":167,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":168,"geoPoint":172,"contacts":173},"Hospital Geral de Caxias do Sul","Caxias do Sul","Rio Grande do Sul",{"type":58,"coordinates":169},[170,171],-51.17944,-29.16806,{"lat":171,"lon":170},[174],{"name":175,"role":43,"phone":176,"phoneExt":23,"email":177},"Emerson B da Silva","55543128700","boschimd@gmail.com",{"facility":179,"status":52,"city":180,"state":167,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":181,"geoPoint":185,"contacts":186},"Hospital de Pronto Socorro de Porto Alegre","Porto Alegre",{"type":58,"coordinates":182},[183,184],-51.23019,-30.03283,{"lat":184,"lon":183},[187],{"name":188,"role":43,"phone":189,"phoneExt":23,"email":190},"Marcelle R Schettert","55-51-3289-7999","marcelle.schettert@portoalegre.rs.gov.br",{"facility":192,"status":52,"city":193,"state":194,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":195,"geoPoint":199,"contacts":200},"Hospital Dr Leo Orsi Bernardes","Itapetininga","São Paulo",{"type":58,"coordinates":196},[197,198],-48.05306,-23.59167,{"lat":198,"lon":197},[201],{"name":202,"role":43,"phone":203,"phoneExt":23,"email":204},"Vivian M Irineu","55-15-3275-7800","virineu@gmail.com",{"facility":206,"status":52,"city":124,"state":23,"zip":23,"country":55,"countryCode":56,"cosmosGeoPoint":207,"geoPoint":209,"contacts":210},"Hospital Pelópidas Silveira",{"type":58,"coordinates":208},[128,129],{"lat":129,"lon":128},[211],{"name":212,"role":43,"phone":213,"phoneExt":23,"email":214},"Livia A de Medeiros","55-81-3183-0388","liviamedeiros@hotmail.com",{"type":216,"investigatorFullName":23,"investigatorTitle":23,"investigatorAffiliation":23,"oldNameTitle":23,"oldOrganization":23},"SPONSOR",[218,220,222],{"name":219,"class":6},"Hospital Sirio-Libanes",{"name":221,"class":6},"Hospital do Coracao",{"name":223,"class":6},"Beneficência Portuguesa de São Paulo","100610919","hydrogen-peroxide-and-ultraviolet-light-for-disinfecting-surfaces-in-intensive-care-units-100610919",false,"NCT07233837","Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units","Hydrogen Peroxide and Ultraviolet Light for Disinfecting Surfaces in Intensive Care Units: A Randomized, Controlled, Cluster, Crossover Clinical Trial","Hylight","Inclusion Criteria:\n\n* All patients aged 18 years and older who will be admitted to the participating ICUs\n\nExclusion Criteria:\n\n* Patients under 18 years\n* ICUs that use peroxide hydrogen or ultraviolet light for surface disinfection as part of their protocol","ALL","18 Years",{"count":235,"type":236},5000,"ESTIMATED","INTERVENTIONAL",[239],"NA","Healthcare-associated infections (HAIs) remain a major problem in intensive care units (ICUs), driven by environmental contamination with multidrug-resistant organisms that persist despite routine manual cleaning. While hydrogen peroxide aerosolization and ultraviolet-C light devices have shown promise in reducing surface contamination, current evidence is inconsistent, mostly derived from single-center studies, and rarely linked to patient-centered outcomes.\n\nThe investigators will conduct this cluster-randomized, crossover trial in 12 Brazilian ICUs. Each ICU will sequentially implement three strategies: (1) usual surface disinfection; (2) usual surface disinfection followed by hydrogen peroxide aerosolization at 7.9% concentration, applied through a dedicated device inside a protective tent during terminal cleaning of patient beds; and (3) usual surface disinfection followed by automated ultraviolet-C irradiation, also applied under the same tent to shield adjacent occupied beds.\n\nThe primary outcome will be the antimicrobial utilization, measured as daily defined doses (DDD) of antimicrobials at the ICU level per 100 patient-days, with secondary outcomes including HAI incidence rate, environmental contamination with multidrug-resistant organisms, specific HAIs incidence rate (associated-ventilator pneumonia, central-line associated bloodstream infection, and catheter-associated urinary tract infection), and ICU length of stay costs.",[242,243,244,245,246],"Infection, Hospital","Antimicrobial","Pneumonia Associated With Mechanical Ventilation","Urinary Tract Infection(UTI)","Catheter Related Blood Stream Infections",[248,249,250,251,252,253,30,36],"Healthcare associated infections","Antimicrobial use","Intensive care units","pneumonia, ventilator-associated","Catheter-related infections","Urinary tract infections","2026-04-10",{"date":256,"type":257},"2026-04-15","ACTUAL",{"date":259,"type":257},"2026-01-05",{"date":261,"type":236},"2027-03-01",{"name":5,"class":6},12]