[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100591313":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":29,"responsibleParty":46,"collaborators":10,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Douglas Mental Health University Institute","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Healthy controls",null,"1. English or French-speaking participants (as dyads matched for language preference).\n2. Ages 18-60 years.\n3. No diagnosis of schizophrenia or schizoaffective illness based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 criteria.",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients","1. English or French-speaking participants (as dyads matched for language preference).\n2. Ages 18-60 years.\n3. Patients meeting the operational criteria for schizophrenia or schizoaffective illness as previously diagnosed by their treating psychiatrist, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 criteria.\n4. Patients with less than 5 years of illness onset, based on the time of starting treatment with antipsychotic medication.",[16],{"name":17,"affiliation":5,"role":18},"Lena Palaniyappan, MD, PhD","PRINCIPAL_INVESTIGATOR",[20,26],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},"Emmanuel Olarewaju, PhD Candidate","CONTACT","5147616131","2005","emmanuel.olarewaju@mail.mcgill.ca",{"name":17,"role":22,"phone":23,"phoneExt":27,"email":28},"6116","lena.palaniyappan@mcgill.ca",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Montreal","Quebec","H4H 1R3","Canada","CA",{"type":38,"coordinates":39},"Point",[40,41],-73.58781,45.50884,{"lat":41,"lon":40},[44,45],{"name":21,"role":22,"phone":23,"phoneExt":24,"email":25},{"name":17,"role":18,"phone":10,"phoneExt":10,"email":10},{"type":18,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Lena Palaniyappan","Professor of Psychiatry","100591313","hyeeg-discourse-in-psychosis-a-neurobehavioural-study-100591313",false,"NCT06978803","HYEEG Discourse in Psychosis: A Neurobehavioural Study","DISCOURSE-NB","Inclusion Criteria:\n\n1. English or French-speaking participants (as dyads matched for language preference).\n2. Ages 18-60 years.\n3. Patients meeting the operational criteria for schizophrenia or schizoaffective illness as previously diagnosed by their treating psychiatrist, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 criteria (Zipursky et al., 2020).\n4. Patients with less than 5 years of illness onset, based on the time of starting treatment with antipsychotic medication.\n\nExclusion Criteria:\n\n1. Participants should not have a primary diagnosis of Alcohol or Drug abuse or addiction (however, co-morbid substance abuse with a primary diagnosis of psychotic disorder is not an exclusion criterion).\n2. Participants should not have a severe medical disorder that would explain psychotic symptoms.\n3. Participants should not have a past or current history of a primary neurological disorder that can affect speech output\n4. Participants with IQ below 70 or a concurrent pervasive developmental disorder (e.g., autism) will also be excluded.",true,"ALL","18 Years","60 Years",{"count":61,"type":62},110,"ESTIMATED","OBSERVATIONAL","This multimodal study explores the mechanisms underlying social dysfunction in individuals with schizophrenia. It focuses on the relationship between disorganized communication and social interaction, aiming to identify measurable markers of disorganized communication and link them to clinical symptoms and social functioning.\n\nKey Research Questions:\n\nHow do neural and behavioural synchrony contribute to social impairments in schizophrenia?\n\nWhat roles do interbrain synchrony, motor imitation, reaction time, and verbal coherence play in disorganized communication?\n\nParticipants will:\n\n1. Engage in structured and semi-structured real-time social interactions while undergoing dual-brain electroencephalogram (EEG) hyperscanning to measure neural and behavioural activity.\n2. Perform nonverbal tasks such as motor imitation and reaction time assessments to investigate coordination and behavioural synchrony patterns.\n3. Participate in a clinical interview that evaluates verbal production, thought coherence, and speech organization.\n\nBy combining these assessments, the study aims to advance our understanding of how social and communication impairments manifest in schizophrenia. The findings will contribute to developing improved diagnostic tools and targeted interventions, ultimately supporting patients in achieving better social functioning and quality of life.",[66,67],"Psychosis","Schizophrenia Disorders",[69,70,71,72,73,74,75,76],"hyperscanning eeg","psychosis","imitation tasks","interbrain synchrony","motor imitation","motor behaviour","speech disorganization","natural language processing","2025-05-11",{"date":79,"type":80},"2025-05-18","ACTUAL",{"date":82,"type":80},"2024-01-16",{"date":84,"type":62},"2026-12-31",{"name":5,"class":6},1]