[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596762":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":11,"centralContacts":27,"locations":33,"responsibleParty":50,"collaborators":11,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":56,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":11,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":74,"overallStatus":78,"whyStopped":11,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Beijing Chao Yang Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"hyperbaric oxygen therapy","EXPERIMENTAL",null,[13],"Other: Hyperbaric Oxygen Therapy",{"label":15,"type":6,"description":11,"interventionNames":16},"Control group",[17],"Other: Conventional therapy group",[19,23],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":11},"Hyperbaric Oxygen Therapy","1.6 atmosphere absolute (1.6 ATA), HBO treatment administrated via mask or hood, one 60 minutes session, once daily, 5 days a week (can be non consecutive days), with a total of 10 sessions.",[9],{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":11},"Conventional therapy group","Conventional therapy",[15],[28],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Shuyuan Yuan","CONTACT","+86 18511703665","shuhua_yuan@126.com",[34],{"facility":35,"status":11,"city":36,"state":11,"zip":11,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Beijing Chaoyang Hospital, Capital Medical University","Beijing","China","CN",{"type":40,"coordinates":41},"Point",[42,43],116.39723,39.9075,{"lat":43,"lon":42},[46],{"name":47,"role":30,"phone":48,"phoneExt":11,"email":49},"Guangxu Liu","+86 010-85231129","bjcyh_yjxbf@163.com",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Jing Yang","Hyperbaric Oxygen Department","100596762","hyperbaric-oxygen-after-stroke-thrombectomy-a-multicenter-randomized-trial-on-safety-and-efficacy-100596762",false,"NCT07049692","Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy","Evaluation of the Efficacy and Safety of Hyperbaric Oxygen in Patients After Endovascular Treatment for Acute Ischemic Stroke: A Multicenter, Open-label, Randomized Controlled Clinical Trial","NOTICE-1","Inclusion Criteria:\n\n* 35-75 years\n* The symptoms and signs are consistent with acute anterior circulation ischemic stroke. The immediate postoperative angiographic recanalization grade was ≥ 2b.\n* Neurological deficit score at the time of enrollment: 5 ≤ NIHSS ≤ 15 points\n* Consciousness status (NIHSS 1a-1b items): 0-1 point\n* Pre-stroke functional status (mRS score): 0-1\n* Time from surgery to randomization grouping: ≤ 72 hours\n* Patient or legal representative who signed the informed consent form\n* Preoperative CT angiography or magnetic resonance angiography confirmed large vessel occlusion (internal carotid artery or middle cerebral artery M1 segment) that was consistent with the symptoms and signs; And the area supplied by the middle cerebral artery in the brain is less than 1\u002F3.\n* A lberta S troke P rogram E arly C T S core ≥ 6\n\nExclusion Criteria:\n\n* Subjects with HBO contraindications or intolerance\n* Postprocedural imaging identified either procedure-related subarachnoid hemorrhage or hemorrhagic transformation\n* Based on the medical history, it is suspected that the cerebral embolism is caused by sepsis or infective endocarditis\n* Expected lifespan \\\u003C 90 days\n* Severe heart, liver and kidneys failure\n* Pregnancy\n* Hereditary or acquired bleeding tendency, deficiency of coagulation factors, recent use of oral anticoagulants with an international normalized ratio (INR) \\> 3 or activated partial thromboplastin time (APTT) exceeding the normal value by more than 3 times\n* Baseline platelet count \\\u003C 50×10 9\u002FL\n* Baseline blood glucose is less than 2.78 mmol\u002FL or greater than 22.2 mmol\u002FL.\n* Unstable vital signs (heart rate ≤ 50 beats\u002Fmin or ≥ 120 beats\u002Fmin, oxygen saturation ≤ 90%, respiration ≥ 30 breaths\u002Fmin or ≤ 10 breaths\u002Fmin);\n* Hypertension that cannot be controlled by medication: Systolic blood pressure ≥ 160 mmHg, or diastolic blood pressure ≥ 100 mmHg;\n* Suspected of having acute myocardial infarction;\n* Currently involving in the research of other projects related to drugs or medical devices.\n* CT or MRI scans revealed intracranial tumors (except for cerebellar meningiomas) and intracranial arteriovenous malformations.\n* Based on the medical history and CT or MRI findings, a diagnosis of internal carotid artery dissection or aortic dissection is suspected;\n* Based on the medical history and CT or MRI findings, cerebral vasculitis is suspected.\n* Based on the clinical evidence of multiple vascular regions being occluded (either in the bilateral anterior circulation or anterior\u002Fposterior circulation) or bilateral infarction or multi-region infarction as detected by CT angiography or magnetic resonance angiography;\n* CT or magnetic resonance imaging shows a significant midline shift effect (\\> 0.5 cm);\n* CT angiography or magnetic resonance angiography confirmed the presence of cerebral vasculitis or cerebral vasculitis syndrome;","ALL","35 Years","75 Years",{"count":66,"type":67},424,"ESTIMATED","INTERVENTIONAL",[70],"NA","1. The goal of this clinical trial is to evaluate the efficacy and safety of hyperbaric oxygen (HBO)in stroke patients after endovascular treatment\n2. The main questions it aims to answer is:\n\n   Whether HBO can improve the prognosis of ischemic stroke patients after endovascular treatment?\n3. Participants will:\n\nreceive HBO (1.6 Atmosphere Absolute，1.6ATA)，Once a day, for 1 hour each time, for 5 days a week (it can be non-consecutive days), the total course of treatment is 10 times.\n\nundergo three scheduled face to face or telephone follow-up assessments during the 12-month period following HBO.",[73],"Acute Ischemic Stroke",[75,76,77],"HBO","acute ischemic stroke","endovascular treatment","NOT_YET_RECRUITING","2025-12-25",{"date":81,"type":82},"2025-12-31","ACTUAL",{"date":84,"type":67},"2026-02-01",{"date":86,"type":67},"2028-03-30",{"name":5,"class":6},1]