[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100461988":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":37,"centralContacts":41,"locations":50,"responsibleParty":69,"collaborators":12,"id":72,"slug":73,"hasResults":74,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":12,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":12,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":12,"overallStatus":52,"whyStopped":12,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"University of Calgary","OTHER",[8,13,19,23,27],{"label":9,"type":10,"description":11,"interventionNames":12},"Room Air","NO_INTERVENTION","All participants will complete an active stand breathing room air with CO2 free to fluctuate",null,{"label":14,"type":15,"description":16,"interventionNames":17},"+0mmHg CO2 Clamped at baseline","EXPERIMENTAL","All participants will complete an active stand with their CO2 held constant at baseline",[18],"Drug: Sequential Gas Delivery",{"label":20,"type":15,"description":21,"interventionNames":22},"+5mmHg CO2","All participants will complete an active stand breathing +5mmHg of CO2 relative to baseline",[18],{"label":24,"type":15,"description":25,"interventionNames":26},"+10mmHg","All participants will complete an active stand breathing +10mmHg of CO2 relative to baseline",[18],{"label":28,"type":15,"description":29,"interventionNames":30},"+10mmHg CO2 + 50mmHg O2","All participants will complete an active stand breathing +10mmHg of CO2 relative to baseline and 50mmHg of O2",[18],[32],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":12},"DRUG","Sequential Gas Delivery","Sequential Gas Delivery will be controlled using the RespirAct™ system (Thornhill Research Inc., Toronto, Canada)",[14,24,28,20],[38],{"name":39,"affiliation":5,"role":40},"Satish R Raj, MD","PRINCIPAL_INVESTIGATOR",[42,47],{"name":43,"role":44,"phone":45,"phoneExt":12,"email":46},"Jacquie Baker, PhD","CONTACT","4032103819","jacquie.baker@ucalgary.ca",{"name":48,"role":44,"phone":12,"phoneExt":12,"email":49},"Rasha Hamzeh, RN","autonomic.research@ucalgary.ca",[51],{"facility":5,"status":52,"city":53,"state":54,"zip":12,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"RECRUITING","Calgary","Alberta","Canada","CA",{"type":58,"coordinates":59},"Point",[60,61],-114.08529,51.05011,{"lat":61,"lon":60},[64,66],{"name":39,"role":44,"phone":65,"phoneExt":12,"email":49},"403-210-6152",{"name":67,"role":44,"phone":68,"phoneExt":12,"email":49},"Robert S Sheldon, MD, PhD","403-220-8191",{"type":40,"investigatorFullName":70,"investigatorTitle":71,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Dr. Satish Raj","Professor","100461988","hypercapnia-in-orthostatic-hypotension-100461988",false,"NCT05295810","Hypercapnia in Orthostatic Hypotension","Investigating Hypercapnia to Treat Neurogenic Orthostatic Hypotension","Inclusion Criteria:\n\n* Age ≥18 years\n* Male and Female\n* Non - smokers.\n* Able and willing to provide informed consent.\n* Ability to travel to Libin Cardiovascular Institute Autonomic Testing Lab at the University of Calgary, Calgary, AB.\n\nExclusion Criteria:\n\n* Medical therapies or medications which could interfere with testing of autonomic function\n* Participants with somatization or severe anxiety symptoms will be excluded\n* Pregnant or breast-feeding females\n* Inability to tolerate mask for the duration of the study\n* Subjects who require portable oxygen at rest or with exercise\n* Subjects with chronic heart failure or severe pulmonary disease who are unable to climb one flight of stairs due to shortness of breath.\n* Presence of failure of other organ systems or systemic illness that can affect autonomic function or the participant's ability to cooperate. These include: dementia, alcohol and\u002For drug abuse, cerebrovascular disease, kidney or liver disease, surgical procedures where the nerves of the sympathetic nervous system have been cut.\n* Other factors which in the investigator's opinion would prevent the participant from completing the protocol, including poor compliance during previous studies.",true,"ALL","18 Years","100 Years",{"count":84,"type":85},80,"ESTIMATED","INTERVENTIONAL",[88],"NA","The Autonomic (or \"automatic\") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP). When someone stands, and gravity tries to pull blood away from the brain, the ANS works to maintain BP and brain blood flow. Neurogenic Orthostatic Hypotension (NOH) occurs when our \"fight-or-flight\" part (\"sympathetic\") of the ANS fails. BP can drop a lot when upright, reducing blood flow and oxygen delivery to the brain, and this can cause symptoms of light-headedness, nausea, and fainting.\n\nOne solution to help counter the effects of NOH may be to increase sympathetic activity by breathing higher levels of carbon dioxide. In healthy volunteers, small increases in the amount of inhaled carbon dioxide has been shown to increase BP in the upright position, and this improves symptoms!\n\nThe objectives of the current study are to apply carbon dioxide in patients with NOH and healthy controls to: (a) evaluate the effects of breathing carbon dioxide on BP and brain blood flow, and (b) determine if a device that increases carbon dioxide while standing will work as a new therapy",[91,92],"Orthostatic Hypotension","Neurogenic Orthostatic Hypotension","2026-04-29",{"date":95,"type":96},"2026-05-05","ACTUAL",{"date":98,"type":96},"2022-03-01",{"date":100,"type":85},"2030-05-31",{"name":5,"class":6},1]