[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100539583":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":35,"centralContacts":39,"locations":48,"responsibleParty":142,"collaborators":10,"id":144,"slug":145,"hasResults":146,"nctId":147,"briefTitle":148,"officialTitle":149,"acronym":10,"eligibilityCriteria":150,"healthyVolunteers":146,"sex":151,"minAge":152,"maxAge":10,"enrollmentInfo":153,"targetDuration":10,"studyType":156,"phases":10,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":171},{"fullName":5,"class":6},"Memorial Sloan Kettering Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"High Risk Pancreatic Cystic Neoplasm",null,"Participants will be diagnosed with a pancreatic cystic neoplasm deemed to be high risk and requiring surgical resection",[13,14,15],"Diagnostic Test: 89Zr-DFO-HuMab-5B1 immunoPET","Diagnostic Test: HP MRI","Combination Product: Blood assay",[17,24,28],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DIAGNOSTIC_TEST","89Zr-DFO-HuMab-5B1 immunoPET","Participants who choose to will undergo immunoPET before surgery.",[9],[23],"immunoPET",{"type":18,"name":25,"description":26,"armGroupLabels":27,"otherNames":10},"HP MRI","Participants who choose to will undergo HP MRI before surgery.",[9],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"COMBINATION_PRODUCT","Blood assay","Will be drawn within 6 weeks of surgery and annually as post operative care",[9],[34],"CA19-.9",[36],{"name":37,"affiliation":5,"role":38},"Kevin Soares, MD","PRINCIPAL_INVESTIGATOR",[40,44],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":43},"CONTACT","212-639-3195","soaresk@mskcc.org",{"name":45,"role":41,"phone":46,"phoneExt":10,"email":47},"David Kelson, MD","646-888-4179","kelsend@MSKCC.ORG",[49,65,76,87,99,110,120,130],{"facility":50,"status":51,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":63},"Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)","RECRUITING","Basking Ridge","New Jersey","07920","United States","US",{"type":58,"coordinates":59},"Point",[60,61],-74.54932,40.70621,{"lat":61,"lon":60},[64],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":66,"status":51,"city":67,"state":53,"zip":68,"country":55,"countryCode":56,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"Memorial Sloan Kettering Monmouth (Limited protocol activities)","Middletown","07748",{"type":58,"coordinates":70},[71,72],-74.11709,40.39428,{"lat":72,"lon":71},[75],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":77,"status":51,"city":78,"state":53,"zip":79,"country":55,"countryCode":56,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"Memorial Sloan Kettering Bergen (Limited Protocol Activities)","Montvale","07645",{"type":58,"coordinates":81},[82,83],-74.02292,41.04676,{"lat":83,"lon":82},[86],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":88,"status":51,"city":89,"state":90,"zip":91,"country":55,"countryCode":56,"cosmosGeoPoint":92,"geoPoint":96,"contacts":97},"Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity)","Commack","New York","11725",{"type":58,"coordinates":93},[94,95],-73.29289,40.84288,{"lat":95,"lon":94},[98],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":100,"status":51,"city":101,"state":90,"zip":102,"country":55,"countryCode":56,"cosmosGeoPoint":103,"geoPoint":107,"contacts":108},"Memorial Sloan Kettering Westchester (Limited Protocol Activities)","Harrison","10604",{"type":58,"coordinates":104},[105,106],-73.71263,40.96899,{"lat":106,"lon":105},[109],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":111,"status":51,"city":90,"state":90,"zip":112,"country":55,"countryCode":56,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Memorial Sloan Kettering Cancer Center (All protocol activites)","10065",{"type":58,"coordinates":114},[115,116],-74.00597,40.71427,{"lat":116,"lon":115},[119],{"name":37,"role":41,"phone":42,"phoneExt":10,"email":10},{"facility":121,"status":122,"city":90,"state":90,"zip":112,"country":55,"countryCode":56,"cosmosGeoPoint":123,"geoPoint":125,"contacts":126},"Weill Cornell Medical Center (Specimen Analysis Only)","NOT_YET_RECRUITING",{"type":58,"coordinates":124},[115,116],{"lat":116,"lon":115},[127],{"name":128,"role":41,"phone":129,"phoneExt":10,"email":10},"David Lyden, MD","212-746-6565",{"facility":131,"status":51,"city":132,"state":90,"zip":133,"country":55,"countryCode":56,"cosmosGeoPoint":134,"geoPoint":138,"contacts":139},"Memorial Sloan Kettering Nassau (Limited Protocol Activites)","Rockville Centre","11553",{"type":58,"coordinates":135},[136,137],-73.64124,40.65871,{"lat":137,"lon":136},[140],{"name":141,"role":41,"phone":42,"phoneExt":10,"email":10},"Kevin Soares, PhD",{"type":143,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100539583","hyperpolarized-c-pyruvate-magnetic-resonance-imaging-and-blood-based-biomarkers-for-early-detection-of-pancreatic-adenocarcinoma-in-patients-with-intraductal-papillary-mucinous-neoplasms-100539583",false,"NCT06305728","Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms","Immuno-Positron Emission Tomography, Hyperpolarized C Pyruvate Magnetic Resonance Imaging, and Blood-Based Biomarkers for Early Detection of Pancreatic Adenocarcinoma in Patients With Intraductal Papillary Mucinous Neoplasms","Inclusion Criteria:\n\n* Men and women aged \\>18 years\n* Pancreatic cystic neoplasm deemed to be high risk and requiring surgical resection\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Pathologic evidence of pancreatic cancer\n* Pregnant or breast-feeding patients\n* Refusal or inability to tolerate scan (eg anxiety or claustrophobia)\n* Inability to lay flat or meet the standard requirements of traditional MRI\n* Hepatic function from assays obtained within 6 weeks prior to the study enrollment. For each patient, the upper limit of normal (ULN) value for a particular assay will be defined by the normal reference values of the laboratory that performed the assay\n\n  1. Bilirubin \\> 1.5 x ULN\n  2. AST\u002FALT \\> 2.5 x ULN\n  3. Albumin \\\u003C 3 g\u002FdL\n  4. GGT \\> 2.5 x ULN if Alkaline Phosphatase \\> 2.5 x ULN\n* Renal function with Creatinine \\> 1.5 x ULN or creatinine clearance \\\u003C 60 mL\u002Fmin, from assays obtained within 6 weeks prior to study enrollment\n* Cardiac: congestive heart failure with New York Heart Association (NYHA) status ≥2, poorly controlled hypertension, a history of clinically significant EKG abnormalities, or myocardial infarction within 6 months of study enrollment.","ALL","18 Years",{"count":154,"type":155},25,"ESTIMATED","OBSERVATIONAL","The purpose of this study is for researchers to find ways of detecting pancreatic ductal adenocarcinoma\u002FPDAC early to avoid the invasive procedure of surgery. The study researchers think a combination of imaging and a series of blood tests may be an effective way to detect PDAC early. In this study, researchers will look at whether a combination of the following types of imaging with blood tests can detect PDAC in pancreatic cysts:\n\n* The ImmunoPET scan (immune-positron emission tomography scan) with the imaging agent 89Zr-DFO-HuMab-5B1\n* The HP MRI scan (hyperpolarized pyruvate magnetic resonance imaging scan)",[159],"Pancreatic Cyst",[159,5,161],"23-367","2025-10-08",{"date":164,"type":165},"2025-10-09","ACTUAL",{"date":167,"type":165},"2024-03-04",{"date":169,"type":155},"2030-03-04",{"name":5,"class":6},8]