[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612937":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":42,"collaborators":44,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"King's College London","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"ADPKD positive",null,"Participants with positive renal MRI and\u002For genetic test for ADPKD",{"label":13,"type":10,"description":14,"interventionNames":10},"ADPKD negative","Participants with negative renal MRI and genetic test for ADPKD",[16],{"name":17,"affiliation":5,"role":18},"Manish Sinha, PhD, MRCP (UK), MRCPCH","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Benjamin Boxer, PhD","CONTACT","+44 20 7188 4770","gstt.hiya.pkd@nhs.net",{"name":26,"role":22,"phone":23,"phoneExt":10,"email":27},"Louise Keehn, MSc","louise.keehn@kcl.ac.uk",[29],{"facility":30,"status":31,"city":32,"state":10,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":10},"Evelina London Children's Hospital","RECRUITING","London","SE1 7EH","United Kingdom","UK",{"type":37,"coordinates":38},"Point",[39,40],-0.12574,51.50853,{"lat":40,"lon":39},{"type":43,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[45],{"name":46,"class":6},"Guy's and St Thomas' NHS Foundation Trust","100612937","hypertension-in-children-and-young-people-at-risk-of-autosomal-dominant-polycystic-kidney-disease-100612937",false,"NCT07260071","Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease","Family Study of Early Hypertension in Children and Young People at Risk of Autosomal Dominant Polycystic Kidney Disease","HIYA-PKD","Inclusion Criteria:\n\n* Age 12 - 17 years at the time of consent\n* Able to tolerate the key study investigations (office blood pressure measurement, ambulatory blood pressure measurement, MRI and blood test)\n* Parent with confirmed clinical diagnosis of ADPKD\n* Parent (if child \\\u003C16 years) or both parent and young person (if \\>=16 years) consents to genetic testing for ADPKD and demonstrates understanding of the implications of this.\n\nExclusion Criteria:\n\n* 18 years or above at the time of study entry\n* Unable to tolerate key study investigations\n* Presence of associated co-morbidities which make it difficult to interpret results, including congenital cardiac anomalies and known TSC-PKD1 mutations\n* Unwilling to undergo genetic testing for ADPKD","ALL","12 Years","17 Years",{"count":59,"type":60},200,"ESTIMATED","OBSERVATIONAL","The goal of this project is to measure the prevalence of Autosomal Dominant Polycystic Kidney Disease (ADPKD) and hypertension in the general population of children and young people at risk of ADPKD, using magnetic resonance imaging (MRI) for rapid diagnosis alongside genetic testing. The main question it aims to answer is:\n\nWhat is the prevalence of hypertension in a population sample of adolescents with ADPKD?\n\nParticipants will have the following measurements performed:\n\n* Height and weight.\n* Blood pressure.\n* Non-invasive measurement of arterial stiffness.\n* Cardiac and renal MRI.\n* Blood sample.\n* Genetic testing.",[64],"Autosomal Dominant Polycystic Kidney Disease (ADPKD",[66,67,68,69,70,71,72,73],"hypertension","children","young people","autosomal dominant polycystic kidney disease","arterial stiffness","genetic testing","albuminuria","proteinuria","2025-11-20",{"date":76,"type":77},"2025-12-02","ACTUAL",{"date":79,"type":77},"2025-08-15",{"date":81,"type":60},"2028-03",{"name":5,"class":6},1]