[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100586008":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":55,"collaborators":25,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":25,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":25,"enrollmentInfo":68,"targetDuration":25,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":82,"whyStopped":25,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"standard arterial line group","SHAM_COMPARATOR","BP, ECG and SpO2 were monitored after entering the operating room, peripheral venous access was established, radial artery puncture catheterization under local anesthesia and connected to TruWave DPT and run data via HemoSphere machine (Edwards Lifesciences). The target of intraoperative blood pressure was to maintain MAP \\> 65mmHg. Timing of treatment and choice of treatment is then left to the discretion of the attending physician.",[13],"Other: standard arterial line",{"label":15,"type":16,"description":17,"interventionNames":18},"HPI guided hemodynamic management group","EXPERIMENTAL","BP, ECG and SpO2 were monitored after entering the operating room, peripheral venous access was established, radial artery puncture catheterization under local anesthesia and connected to the HPI (Edwards Lifesciences).\n\nThe treating anesthetist is trained to understand Acumen IQ parameters and the meaning of HPI, MAP, CI, SVI, SVR, SVV, Eadyn, dP\u002Fdtmax. The treating anesthetist is provided with guidance by means of a flowchart suggesting when to treat and how to treat hypotension. The hemodynamic management is performed according to the HPI guided algorithm.",[19],"Procedure: HPI guided hemodynamic management",[21,26],{"type":22,"name":23,"description":17,"armGroupLabels":24,"otherNames":25},"PROCEDURE","HPI guided hemodynamic management",[15],null,{"type":6,"name":27,"description":11,"armGroupLabels":28,"otherNames":25},"standard arterial line",[9],[30],{"name":31,"role":32,"phone":33,"phoneExt":25,"email":34},"Zheng Guan","CONTACT","86-13572592715","guanzheng@xjtufh.edu.cn",[36],{"facility":37,"status":25,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"the First Affiliated Hospital of Xi'an Jiaotong University","Xi'an","Shaanxi","710061","China","CN",{"type":44,"coordinates":45},"Point",[46,47],108.92861,34.25833,{"lat":47,"lon":46},[50,53],{"name":31,"role":32,"phone":51,"phoneExt":25,"email":52},"+8613572592715","guanzheng1980@126.com",{"name":54,"role":32,"phone":25,"phoneExt":25,"email":25},"Guan",{"type":56,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Guan Zheng","associate professor","100586008","hypotension-prediction-index-and-intraoperative-hypotension-incidence-100586008",false,"NCT06909786","Hypotension Prediction Index and Intraoperative Hypotension Incidence","Effect of Intraoperative Implementation of the Hypotension Prediction Index (HPI) Guided Management Strategy on Incidents of Intraoperative Hypotension Among Frail Patients Undergoing Major Abdominal Surgery","Inclusion Criteria:\n\n* Age\\> 60 years old\n* Frail score \\> 2\n* ASA≥2\n* Planned to receive general anesthesia\n* Elective laparoscopic or laparotomy major abdominal surgery with an expected duration of \\> 180 minutes\n* Planned to receive an arterial line monitoring intraoperatively\n* Being able to give written informed consent prior to surgery\n\nExclusion Criteria:\n\n* Severe cardiac arrhythmia including atrial fibrillation\n* Severe aortic stenosis\n* Uncontrolled Hypertension (sitting systolic blood pressure ≥ 160 mmHg and\u002For diastolic blood pressure ≥100 mmHg during screening)\n* Significant hypotension before surgery defined as a MAP \\\u003C65mmHg\n* Chronic kidney disease with glomerular filtration rate \\\u003C30 ml\u002Fmin\u002F1.73 m2 or requiring renal-replacement therapy for end-stage renal disease\n* Organ transplant surgery, surgery involving the kidney, liver surgery requiring hilar blockage, surgery requiring controlled hypotension or controlled low central venous pressure","ALL","60 Years",{"count":69,"type":70},100,"ESTIMATED","INTERVENTIONAL",[73],"NA","This study aim to implement intraoperative hemodynamic monitoring and management guided with HPI algorithm in frail patients undergoing elective abdominal surgery. Investigators hypothesize that the use of this algorithm will alter treatment of hypotension and reduces the amount of hypotension as measured by the time weighted average (TWA) during non-cardiac surgery and to anticipate a reduction of postoperative AKI incidents, to explore the clinical benefits of impact of Acumen guided algorithm hemodynamic management in postoperative intestinal function recovery, and postoperative cardiac complications.",[76],"Intraoperative Hypotension",[78,79,80,81],"intraoperative hypotension","hypotension prediction index","frail patient","acute kidney injury","NOT_YET_RECRUITING","2025-03-27",{"date":85,"type":86},"2025-04-04","ACTUAL",{"date":88,"type":70},"2025-04-01",{"date":90,"type":70},"2025-12-31",{"name":5,"class":6},1]