[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616107":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":41,"responsibleParty":59,"collaborators":62,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":26,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":26,"enrollmentInfo":73,"targetDuration":26,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"National and Kapodistrian University of Athens","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"HPI\u002FAFM - Goal- Directed Hemodynamic Therapy","EXPERIMENTAL","Participants will receive goal-directed hemodynamic therapy guided by the Hypotension Prediction Index and Assisted Fluid Management software, using the Hemosphere monitor.\n\nInterventions include protocol-guided fluid and vasopressors to prevent or treat intraoperative hypotension.",[13],"Device: Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional therapy","ACTIVE_COMPARATOR","Participants will receive conventional hemodynamic intraoperative management based on anesthesiologist's clinical judgement. The Acumen IQ sensor will be placed but Hypotension Prediction Index and Assisted Fluid Management outputs will not be visible to the anesthesiologist.",[19],"Other: Conventional Intraoperative Hemodynamic management",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Acumen IQ sensor with Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) software","The Acumen IQ sensor will be used with the Hemosphere monitor to guide goal-directed hemodynamic therapy. HPI predicts impending hypotension and AFM guides fluid administration. Clinicians will follow a protocol algorithm to prevent or treat intraoperative hypotension with fluids, vasopressors or inotropes.",[9],null,{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional Intraoperative Hemodynamic management","Participants receive hemodynamic management based on the anesthesiologist's clinical judgement. The Acumen IQ sensor will be placed , but HPI and AFM outputs are not visible to the clinician.",[15],[32],{"name":33,"affiliation":34,"role":35},"Georgia Ntalamagka, MD","Attikon Hospital","PRINCIPAL_INVESTIGATOR",[37],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","+306978210163","geo.dalamaga@gmail.com",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"2nd University Department of Anesthesiology, Attikon University Hospital","RECRUITING","Athens","Attica","12462","Greece","GR",{"type":51,"coordinates":52},"Point",[53,54],23.72784,37.98376,{"lat":54,"lon":53},[57],{"name":58,"role":38,"phone":39,"phoneExt":26,"email":40},"Georgia Ntalamagka",{"type":35,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":34,"oldNameTitle":26,"oldOrganization":26},"NTALAMAGKA GEORGIA","Principal Investigator",[63],{"name":34,"class":6},"100616107","hypotension-prediction-index-hpi-and-assisted-fluid-management-afm-for-perioperative-hemodynamic-optimization-in-patients-under-general-anesthesia-100616107",false,"NCT07301307","Hypotension Prediction Index (HPI) and Assisted Fluid Management (AFM) for Perioperative Hemodynamic Optimization in Patients Under General Anesthesia","The Use of the Hypotension Prediction Index (HPI) Combined With the Assisted Fluid Management (AFM) Software for Perioperative Hemodynamic Optimization in Patients Undergoing General Anesthesia.","Inclusion Criteria:\n\n* Age \\> 18 years\n* Intraoperative monitoring \\> 2 hours or general anesthesia \\> 2 hours\n* Invasive arterial pressure monitoring\n* Target MAP ≥ 65 mm Hg intraoperatively\n* Written informed consent preoperatively\n* ASA Physical Status ≤ 4\n\nExclusion Criteria:\n\n* Target MAP other than 65 mm Hg\n* Severe preoperative hypotension (MAP \\\u003C 65 mm Hg)\n* Severe heart failure (e.g. LVEF \\\u003C 20%)\n* Emergency surgery","ALL","18 Years",{"count":74,"type":75},100,"ESTIMATED","INTERVENTIONAL",[78],"NA","This study investigates if the Hypotension Prediction Index (HPI) combined with the Assisted Fluid Management (AFM) software can improve perioperative hemodynamic management in adult patients undergoing general anesthesia. The main question is :\n\nDoes the HPI and AFM software reduce the incidence and duration of intraoperative hypotension? Does the HPI and AFM software optimize fluid and vasopressor administration? Does the HPI and AFM software improve perioperative outcomes? Participants will be randomly allocated to either an experimental group receiving goal directed hemodynamic therapy guided by HPI and AFM or a control group receiving conventional hemodynamic management.",[81],"Intraoperative Hypotension",[81,83,84,85,86,87,88,89],"Perioperative Hemodynamic Optimization","Goal-Directed Hemodynamic Therapy","Hypotension Prediction Index","Assisted Fluid Management","Invasive Arterial Pressure Monitoring","Artificial Intelligence","Perioperative Care","2026-04-16",{"date":92,"type":93},"2026-04-20","ACTUAL",{"date":95,"type":93},"2026-03-15",{"date":97,"type":75},"2027-03",{"name":5,"class":6},1]