[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515330":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":35,"locations":40,"responsibleParty":88,"collaborators":90,"id":92,"slug":93,"hasResults":94,"nctId":95,"briefTitle":96,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":94,"sex":99,"minAge":100,"maxAge":18,"enrollmentInfo":101,"targetDuration":18,"studyType":104,"phases":105,"briefSummary":107,"conditions":108,"keywords":111,"overallStatus":72,"whyStopped":18,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"Vilnius University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"APP group","EXPERIMENTAL","Awake prone position (APP) for 4 or more hours per day in addition to standard care for the first 72 hours from randomisation. After the initial period, use of APP is at discretion of the treating clinician. Awake prone can be discontinued earlier if patients meets pre-specified criteria of sustained improvement.",[13],"Behavioral: Awake prone position (APP)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Standard care excluding APP",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"BEHAVIORAL","Awake prone position (APP)","Awake prone position for 4 or more hours per day for the first 72 hours following randomisation.",[9],[26,30,33],{"name":27,"affiliation":28,"role":29},"Ieva Jovaisiene, Dr","Vilnius University Hospital Santaros Klinikos","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":32,"role":29},"Mandeep K Phull, Dr","Barking, Havering and Redbridge University Hospitals NHS Trust",{"name":34,"affiliation":28,"role":29},"Tomas Jovaisa, Prof",[36],{"name":34,"role":37,"phone":38,"phoneExt":18,"email":39},"CONTACT","+37062697567","tomas.jovaisa@santa.lt",[41,58,71,76],{"facility":42,"status":43,"city":44,"state":18,"zip":18,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Hospital of Lithuanian University of Health Sciences Kaunas Clinics","NOT_YET_RECRUITING","Kaunas","Lithuania","LT",{"type":48,"coordinates":49},"Point",[50,51],23.90909,54.90156,{"lat":51,"lon":50},[54],{"name":55,"role":37,"phone":56,"phoneExt":18,"email":57},"Tomas Tamosuitis, Dr","+37068780950","Tomas.Tamosuitis@kaunoklinikos.lt",{"facility":59,"status":43,"city":60,"state":18,"zip":61,"country":45,"countryCode":46,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Republican Vilnius University Hospital","Vilnius","04130",{"type":48,"coordinates":63},[64,65],25.2798,54.68916,{"lat":65,"lon":64},[68],{"name":69,"role":37,"phone":18,"phoneExt":18,"email":70},"Saulius Vosylius, Prof","saulius.vosylius@gmail.com",{"facility":28,"status":72,"city":60,"state":18,"zip":18,"country":45,"countryCode":46,"cosmosGeoPoint":73,"geoPoint":75,"contacts":18},"RECRUITING",{"type":48,"coordinates":74},[64,65],{"lat":65,"lon":64},{"facility":32,"status":43,"city":77,"state":18,"zip":18,"country":78,"countryCode":79,"cosmosGeoPoint":80,"geoPoint":84,"contacts":85},"London","United Kingdom","UK",{"type":48,"coordinates":81},[82,83],-0.12574,51.50853,{"lat":83,"lon":82},[86],{"name":31,"role":37,"phone":18,"phoneExt":18,"email":87},"mandeep.phull@nhs.net",{"type":89,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[91],{"name":28,"class":6},"100515330","hypoxaemic-respiratory-failure-and-awake-prone-ventilation-100515330",false,"NCT05990101","HYPoxaEmic Respiratory Failure and Awake Prone Ventilation","Hyper-AP","Inclusion Criteria:\n\n* Adult patients admitted to intensive care unit for acute hypoxemic respiratory failure.\n* Acute hypoxemic respiratory failure is defined by respiratory rate ≥25 breaths\u002Fmin, and partial pressure of oxygen in the arterial blood (PaO2)\u002Ffraction of inspired oxygen (FiO2) ≤300 mm Hg or oxygen saturation (SpO2)\u002Ffraction of inspired oxygen (FiO2) ratio \\\u003C235 while spontaneously breathing under standard oxygen with oxygen flow rate of at least 10 L\u002Fmin, high flow oxygen therapy or non-invasive ventilation. For patients under standard oxygen, FiO2 is calculated according to the following formula: FiO2=0.21 + 0.03 per litre of supplemental oxygen.\n* Informed consent\n\nExclusion Criteria:\n\n* impaired consciousness - Glasgow coma score \\\u003C14;\n* inability to cooperate or prone position intolerance;\n* immediate indications for endotracheal intubation;\n* patients with do-not-intubate order at time of inclusion;\n* patients with contraindication to high flow oxygen therapy (HFOT) or non-invasive ventilation (NIV);\n* Partial pressure of carbon dioxide (PaCO2) above 50 mm Hg and quantitative measure of the acidity (pH) \\\u003C7,3;\n* vasopressor dose \\>0.3 µg\u002Fkg\u002Fmin of norepinephrine-equivalent to maintain systolic blood pressure \\>90 mmHg;\n* Covid-19 positive","ALL","18 Years",{"count":102,"type":103},262,"ESTIMATED","INTERVENTIONAL",[106],"NA","The goal of this prospective multi-centre randomised controlled trial is to determine if addition of awake prone positioning to standard oxygen, high flow oxygen therapy and non-invasive ventilation may reduce the rates of endotracheal intubation and mechanical ventilation.",[109,110],"Respiratory Failure","Hypoxemia",[112,113,114,115],"Awake prone","Respiratory failure","ARDS","Hypoxaemia","2023-08-04",{"date":118,"type":119},"2023-08-14","ACTUAL",{"date":121,"type":119},"2023-05-12",{"date":123,"type":103},"2028-09-01",{"name":5,"class":6},4]