[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100606847":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":30,"centralContacts":30,"locations":30,"responsibleParty":31,"collaborators":30,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":43,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":30,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":30,"overallStatus":56,"whyStopped":30,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":30},{"fullName":5,"class":6},"Pharos University in Alexandria","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Hypoventilation Training group","EXPERIMENTAL","* Mode: Stationary cycling (ergometer).\n* Intensity: Moderate (40-60% VO₂max or Borg RPE 11-13).\n* Duration: 30 minutes per session.\n* Frequency: 3 sessions per week, for 12 weeks.\n* Technique:\n\n  * Patients instructed to hold their breath (hypoventilation) for 5-10 seconds every 2-3 minutes during cycling.\n  * Breathing then resumes normally until recovery.\n  * Cycle repeated throughout the session",[13],"Behavioral: hypoventilation group",{"label":15,"type":10,"description":16,"interventionNames":17},"Breathing Restriction Mask Training","* Mode: Stationary cycling (ergometer).\n* Intensity: Moderate (same as Group A: 40-60% VO₂max).\n* Duration: 30 minutes per session.\n* Frequency: 3 sessions per week, for 12 weeks.\n* Equipment: Commercially available breathing restriction mask (e.g., altitude simulation mask).\n* Technique:\n\n  * Mask settings adjusted to provide increasing resistance over time, simulating hypoxic breathing (FiO₂ \\~14-16%).\n  * Patients cycle continuously with mask worn throughout the session.\n* Monitoring:\n\n  * SpO₂, HR, BP monitored continuously.\n  * Mask removed immediately if SpO₂ \\\u003C 88% or severe dyspnea occurs.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Control Group (Conventional Aerobic Training)","ACTIVE_COMPARATOR","* Mode: Stationary cycling (ergometer).\n* Intensity: Moderate (40-60% VO₂max or Borg RPE 11-13).\n* Duration: 30 minutes per session.\n* Frequency: 3 sessions per week, for 12 weeks.\n* Technique:\n\n  * Continuous cycling at steady pace.\n  * No hypoventilation or mask used.\n* Monitoring:\n\n  o HR, BP, and SpO₂ checked pre- and post-session.\n* Progression:\n\n  * Workload (watts) increased every 2-3 weeks to maintain moderate intensity",[13],[24],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"BEHAVIORAL","hypoventilation group","Traditional Aerobic Training Participants will perform supervised aerobic exercise (e.g., cycling or treadmill walking) under controlled intermittent hypoxic conditions.\n\nHypoxia protocol: alternating cycles of low-oxygen exposure (FiO₂ 12-16%) for 3-5 minutes followed by normoxic recovery for 2-3 minutes, repeated 6-8 times per session.\n\nFrequency: 3 sessions per week for 12 weeks.\n\nExercise intensity: Moderate (50-70% of heart rate reserve), adjusted individually based on baseline exercise testing",[15,19,9],[15],null,{"type":32,"investigatorFullName":33,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Ola Mohamed Elsayed Elgohary","ola mohamed elgohary","100606847","hypoxic-vs-aerobic-training-in-chronic-kidney-disease-100606847",false,"NCT07180875","\"Hypoxic vs. Aerobic Training in Chronic Kidney Disease","Simulated Hypoxia Training to Enhance Exercise Tolerance in Stage 3 Chronic Kidney Disease: A Randomized Controlled Trial","IHT-CKD","Inclusion Criteria:Adults (40-65 years) diagnosed with CKD stages 3a,b\n\n* Medically stable and cleared for exercise\n\nExclusion Criteria:\n\n* Uncontrolled hypertension\n* Severe cardiac arrhythmias\n* Recent hospitalization (\\\u003C3 months)\n\ncardiovascular disese unstable",true,"ALL","40 Years","65 Years",{"count":48,"type":49},60,"ESTIMATED","INTERVENTIONAL",[52],"NA","Chronic kidney disease (CKD) leads to poor exercise tolerance, vascular dysfunction, and reduced quality of life. This randomized controlled trial will compare intermittent hypoxic training (IHT) with traditional aerobic training in patients with CKD stages 3-4.\n\nA total of 60 participants aged 40-65 years will be recruited and randomized into three groups. Interventions will last 12 weeks, with three 30-minute supervised sessions per week. Outcome measures include exercise tolerance (6-Minute Walk Test), cardiovascular parameters (blood pressure, heart rate recovery), kidney function (serum creatinine, eGFR), fatigue (Fatigue Severity Scale), and quality of life (KDQOL-36)",[55],"Chronic Kidney Disease (CKD), Stages 3-4 Exercise Tolerance \u002F Functional Capacity Vascular Health \u002F Arterial Stiffness Fatigue in CKD","NOT_YET_RECRUITING","2025-12-18",{"date":59,"type":60},"2025-12-24","ACTUAL",{"date":62,"type":49},"2025-12-09",{"date":64,"type":49},"2026-02-01",{"name":5,"class":6}]