[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638554":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":22,"centralContacts":33,"locations":45,"responsibleParty":94,"collaborators":96,"id":100,"slug":101,"hasResults":102,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":106,"eligibilityCriteria":107,"healthyVolunteers":102,"sex":108,"minAge":109,"maxAge":110,"enrollmentInfo":111,"targetDuration":10,"studyType":114,"phases":10,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},{"fullName":5,"class":6},"Foundation Endourology","OTHER",[8],{"label":9,"type":10,"description":9,"interventionNames":11},"Percutaneous nephrolithotripsy (PCNL)",null,[12],"Procedure: Percutaneous nephrolithotomi (PCNL)",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"PROCEDURE","Percutaneous nephrolithotomi (PCNL)","Patients included in this observational study undergo Percutaneous Nephrolithotomy (PCNL) for the treatment of renal calculi according to the established protocols of each participating center. The surgical procedure involves creating a percutaneous tract to the renal collecting system under ultrasound, fluoroscopic, or combined guidance. The study observes a wide spectrum of contemporary techniques, including standard-tract PCNL and miniaturized versions (Mini-PCNL), performed in either prone or supine positions. Specific procedural data are recorded, including the method of tract dilation (balloon, telescopic, or single-step), the type of lithotripsy energy used (laser, ultrasonic, or pneumatic), and postoperative drainage strategies (standard nephrostomy, tubeless, or stent-only). As an observational study, the choice of specific technique and equipment is determined by the treating surgeon based on clinical indications and institutional standards.",[9],[20,21],"PCNL","mini PCNL",[23,27,30],{"name":24,"affiliation":25,"role":26},"Kemal Sarika, PhD","Sancaktepe Training and Research Hospital, Istanbul, Turkiye","STUDY_CHAIR",{"name":28,"affiliation":29,"role":26},"Guohua Zeng, PhD","The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China",{"name":31,"affiliation":32,"role":26},"Simon Choong, PhD","Institute of Urology, University College London Hospitals, London, United Kingdom",[34,40],{"name":35,"role":36,"phone":37,"phoneExt":38,"email":39},"Iliya P Saltirov, DSc","CONTACT","+359888723744","888723744","iliya.saltirov@gmail.com",{"name":41,"role":36,"phone":42,"phoneExt":43,"email":44},"Ognyan H Gatsev, PhD","+359883490750","883490750","gatsev@gmail.com",[46,69,76,83],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Sofia","Sofia-Grad","1606","Bulgaria","BG",{"type":54,"coordinates":55},"Point",[56,57],23.32415,42.69751,{"lat":57,"lon":56},[60,62,64,67,68],{"name":61,"role":36,"phone":37,"phoneExt":10,"email":39},"Iliya Saltirov, DSc",{"name":63,"role":36,"phone":42,"phoneExt":10,"email":44},"Ognyan Gatsev, PhD",{"name":65,"role":66,"phone":10,"phoneExt":10,"email":10},"Kemal Sarica, PhD","PRINCIPAL_INVESTIGATOR",{"name":28,"role":66,"phone":10,"phoneExt":10,"email":10},{"name":31,"role":66,"phone":10,"phoneExt":10,"email":10},{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":70,"geoPoint":72,"contacts":73},{"type":54,"coordinates":71},[56,57],{"lat":57,"lon":56},[74,75],{"name":61,"role":36,"phone":37,"phoneExt":10,"email":39},{"name":63,"role":36,"phone":42,"phoneExt":10,"email":44},{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":77,"geoPoint":79,"contacts":80},{"type":54,"coordinates":78},[56,57],{"lat":57,"lon":56},[81,82],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":39},{"name":41,"role":36,"phone":42,"phoneExt":10,"email":44},{"facility":84,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":85,"geoPoint":87,"contacts":88},"Military Medical Academy, Department of Urology and Nephrology",{"type":54,"coordinates":86},[56,57],{"lat":57,"lon":56},[89,90,91,92,93],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":39},{"name":41,"role":36,"phone":42,"phoneExt":10,"email":44},{"name":65,"role":66,"phone":10,"phoneExt":10,"email":10},{"name":28,"role":66,"phone":10,"phoneExt":10,"email":10},{"name":31,"role":66,"phone":10,"phoneExt":10,"email":10},{"type":95,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[97],{"name":98,"class":99},"The International Alliance of Urolithiasis","NETWORK","100638554","iau-percutaneous-nephrolithotripsy-study-100638554",false,"NCT07622238","IAU Percutaneous Nephrolithotripsy Study","International Alliance of Urolithiasis Percutaneous Nephrolithotripsy Study","IAUPCNL","Inclusion Criteria:\n\n* Patient age 18 years or older at the time of enrollment.\n* Diagnosed with single or multiple renal calculi (including complex and staghorn calculi) or proximal ureteral stones.\n* Scheduled to undergo any primary or secondary percutaneous surgical stone intervention, including standard percutaneous nephrolithotomy (PCNL) or any of its miniaturized variations (Mini-PCNL, Ultra-mini PCNL, Super-mini PCNL, or Micro-PCNL).\n* Voluntarily provided written informed consent for participation and data utilization.\n\nExclusion Criteria:\n\n* Patient age under 18 years.\n* Patients scheduled to undergo alternative primary treatment modalities for the targeted stone burden as a standalone procedure (e.g., retrograde intrarenal surgery \\[RIRS\\] or shockwave lithotripsy \\[SWL\\]).\n* Presence of an active, untreated urinary tract infection (UTI) or clinical urosepsis at the time of the scheduled surgical procedure.\n* Uncorrected severe coagulopathy or uncorrectable bleeding diathesis.\n* Missing, incomplete, or unavailable medical charts or follow-up records rendering outcome assessment impossible.","ALL","18 Years","100 Years",{"count":112,"type":113},4000,"ESTIMATED","OBSERVATIONAL","During the past 10-15 years, important advancements have been witnessed in percutaneous nephrolithotomy (PCNL) techniques and instrumentation. The development of miniaturized PCNL techniques and modern laser technologies has contributed to lower complication rates, alongside changes in exiting strategies and postoperative drainage protocols. Ultrasound is increasingly utilized to create percutaneous access, and many medical centers have transitioned to the supine position for PCNL or perform Endoscopic Combined Intrarenal Surgery (ECIRS). All these developments have helped to individualize treatment strategies and to improve clinical outcomes for patients. However, there remains an ongoing discussion regarding the optimal indications and limitations of the different miniaturized PCNL techniques compared to standard PCNL and retrograde intrarenal surgery (RIRS).\n\nThis prospective observational study is organized under the auspices of the International Alliance of Urolithiasis (IAU) and focuses on the contemporary indications, surgical techniques, instrumentation, exiting strategies, efficacy, and risk factors for intraoperative and postoperative complications of PCNL. Participating investigators will collect data on the PCNL procedures performed in their respective clinical centers prospectively for a period of 12-18 months. The study will be initiated in each clinical center following formal approval from the IAU Scientific Committee, which will also announce the conclusion of the study.",[117,118],"Urolithiasis","Kidney Calculi",[120,121,122,117,123,124,125],"Percutaneous Nephrolithotomy","Standart PCNL","Mini-PCNL","Kidney Stones","Postoperative Complications","Efficacy","2026-05-30",{"date":128,"type":129},"2026-06-03","ACTUAL",{"date":131,"type":129},"2019-08-15",{"date":133,"type":113},"2026-06-15",{"name":5,"class":6},4]