[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100300548":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":27,"centralContacts":31,"locations":39,"responsibleParty":60,"collaborators":62,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":10,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Second Affiliated Hospital of Guangzhou Medical University","OTHER",[8,14,17],{"label":9,"type":10,"description":11,"interventionNames":12},"Study group (A group)",null,"In this group, we perform whole exome or genome sequencing of tumor sample in compared to blood sample, screen tumor-related special mutations by using biomedical informatics analysis procedure and utilized the iCAGES system to rank the most appropriate drugs available and then manually examine this list to select the best therapeutic strategy for the patient based on availability of drug and expert knowledge. The PFS, OS, and quality of life (QOL) will be recorded and compared with that from standard care.",[13],"Drug: inhibitors, ADC drugs such as tarceva, capmatinib, padcev et al for A\u002FC group.",{"label":15,"type":10,"description":16,"interventionNames":10},"Control group (B group)","In this group, patients with advanced cancers (matched with Group A) will be treated under the guidance of NCCN, without performing iCAGES analysis.",{"label":18,"type":10,"description":19,"interventionNames":20},"Control group (C group)","In this group, patients with advanced cancers (matched with Group A) will be treated with appropriate targeted drugs according to IHC detection of more than 20 protein molecules with blank tissue slides from the cancer.",[13],[22],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":10},"DRUG","inhibitors, ADC drugs such as tarceva, capmatinib, padcev et al for A\u002FC group.","Choose appropriate targeted drugs according to NGS\u002FIHC results.",[18,9],[28],{"name":29,"affiliation":5,"role":30},"Zhenfeng Zhang, MD,PhD","PRINCIPAL_INVESTIGATOR",[32,36],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","+86-020-34153532","zhangzhf@gzhmu.edu.cn",{"name":37,"role":33,"phone":34,"phoneExt":10,"email":38},"Deji Chen, MD,PhD","chendeji2003@163.com",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"The Second Affiliated Hospital of Guangzhou Medical University","RECRUITING","Guangzhou","Guangdong","510260","China","CN",{"type":49,"coordinates":50},"Point",[51,52],113.25,23.11667,{"lat":52,"lon":51},[55,56,58],{"name":29,"role":33,"phone":34,"phoneExt":10,"email":35},{"name":57,"role":30,"phone":10,"phoneExt":10,"email":10},"Jiexia Zhang, MD,PhD",{"name":59,"role":30,"phone":10,"phoneExt":10,"email":10},"Ming Zhao, MD,PhD",{"type":61,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[63,65],{"name":64,"class":6},"The First Affiliated Hospital of Guangzhou Medical University",{"name":66,"class":6},"Sun Yat-sen University","100300548","icages-guided-precision-therapy-for-cancers-in-contrast-to-standard-care-or-ihc-guided-theray-100300548",false,"NCT03192501","iCAGES-guided Precision Therapy for Cancers in Contrast to Standard Care or IHC-guided Theray","Multicentre Perspective Non-interventional Study of Survival Benefits of iCAGES-guided Therapy in Contrast to Standard Therapy or IHC-guided Therapy for Advanced Cancers","Inclusion Criteria:\n\n* Pathological and clinical diagnosis of recurrence \u002F metastatic lung cancer or other advanced cancers.\n* There are PACS images available at the Second Affiliated Hospital of Guangzhou Medical University and the collaborated Hospitals.\n* The patient is informed consent and signed a written consent.\n\nExclusion Criteria:\n\n* Age \\> 70 or \\\u003C18 years old.\n* Previous history of malignant tumors.\n* Pregnant or lactating female patients.\n* Any serious concomitant disease that is expected to have an adverse effect on prognosis, including the heart disease that treatment is required, unsatisfactory controlled diabetes and psychiatric disorders.","ALL","18 Years","70 Years",{"count":78,"type":79},250,"ESTIMATED","OBSERVATIONAL","This study prospectively evaluates whether the use of iCAGES (integrated CAncer GEnome Score) tool in guiding the treatment of advanced cancers is superior to current standard care or IHC-guided therapy in progress free survival (PFS),overall survival (OS),and improvement of life quality.",[83,84,85,86],"Lung Cancer","Gene Abnormality","Gene Product Sequence Variation","Cancer",[88,89,90,91,92,93,94],"lung cancer","iCAGES","gene mutation","precision medicine","advanced cancers","IHC","Targeted therapy","2024-06-22",{"date":97,"type":98},"2024-06-25","ACTUAL",{"date":100,"type":98},"2017-07-01",{"date":102,"type":79},"2039-07-01",{"name":5,"class":6},1]