[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530991":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":21,"responsibleParty":47,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":52,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":71,"overallStatus":24,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"University of Manitoba","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"ICU survivors",null,"Patients who have received prolonged mechanical ventilation (7 days or more) in the intensive care unit (ICU), and have been discharged from hospital.",[13],{"name":14,"affiliation":5,"role":15},"Asher Mendelson, MD PhD","PRINCIPAL_INVESTIGATOR",[17],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":20},"CONTACT","204-787-1634","Asher.Mendelson@umanitoba.ca",[22,39],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":36},"St. Boniface General Hospital","RECRUITING","Winnipeg","Manitoba","R2H 2A6","Canada","CA",{"type":31,"coordinates":32},"Point",[33,34],-97.14704,49.8844,{"lat":34,"lon":33},[37],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":38},"asher.mendelson@umanitoba.ca",{"facility":40,"status":24,"city":25,"state":26,"zip":41,"country":28,"countryCode":29,"cosmosGeoPoint":42,"geoPoint":44,"contacts":45},"Health Sciences Centre Winnipeg","R3A 1R9",{"type":31,"coordinates":43},[33,34],{"lat":34,"lon":33},[46],{"name":14,"role":18,"phone":19,"phoneExt":10,"email":38},{"type":15,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Asher Mendelson","Assistant Professor","100530991","icu-combined-assessment-of-cardio-respiratory-exercise-100530991",false,"NCT06193980","ICU Combined Assessment of Cardio-Respiratory Exercise","Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness","ICU-CARE","Inclusion Criteria:\n\n* Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Trajectory of health expected to be significantly limited in the upcoming 12 months\n* those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity\n* have significant orthopedic or musculoskeletal impairment affecting mobility\n* have a medical history of neuromuscular disease\n* ongoing respiratory limitations (i.e., supplemental oxygen)\n* significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)\n* a body mass index (BMI) of ≥ 40 kg\u002Fm2 (impacting NIRS signal due to adipose tissue thickness)\n* if participant's primary residence is a significant distance from the participating study site","ALL","18 Years",{"count":61,"type":62},50,"ESTIMATED","OBSERVATIONAL","This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness\u002Fdysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.",[66,67,68,69,70],"ICU Acquired Weakness","Sepsis","Shock","Critical Illness","Microcirculation",[72,73,70,74,75,76,77,78],"ICU Survivors","Oxygen Delivery","skeletal muscle","Exercise","near-infrared spectroscopy","cardiopulmonary exercise test","cardiovascular physiology","2026-06-11",{"date":81,"type":82},"2026-06-15","ACTUAL",{"date":84,"type":82},"2023-12-15",{"date":86,"type":62},"2029-12",{"name":5,"class":6},2]