[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100053237":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":43,"locations":52,"responsibleParty":70,"collaborators":30,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":30,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":30,"overallStatus":54,"whyStopped":30,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Endeavor Health","OTHER",[8,16,20],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy","ACTIVE_COMPARATOR","Healthy volunteers will be recruited primarily through flyers placed in Endeavor Health hospitals and surrounding communities. They will undergo NCS, EMG, and Tetragraph testing on days 1,5,10",[13,14,15],"Device: TetraGraph","Device: Electromyography","Device: Nerve conduction studies",{"label":17,"type":10,"description":18,"interventionNames":19},"Critically Ill patients","Critically ill, non-intubated patients in an Endeavor Health ICU. They will undergo NCS, EMG, and Tetragraph testing on days 1,5,10",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Intubated ICU patients","ICU patients that are intubated within the first 72 hours of their ICU stay as our preliminary data suggested the CMAP amplitudes started to drop after this time. they will undergo NCS, EMG, and Tetragraph testing on days 1,5,10",[13,14,15],[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","TetraGraph","The TetraGraph is a non-invasive surface nerve conduction study (NCS) device, currently FDA-approved for monitoring perioperative neuromuscular blockade depth. The device delivers brief (0.2 msec) electrical stimuli to the patient's hand (abductor digiti minimi) or lower leg (tibialis anterior) to monitor the compound action potential.",[17,9,21],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Electromyography","Electromyography (EMG) is an FDA-approved diagnostic procedure that involves inserting a needle electrode into muscle tissue to record its electrical activity. In this study, EMG findings will primarily be performed to rule out other causes of weakness and to help confirm the suspected diagnosis of CIP and\u002For CIM.",[17,9,21],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Nerve conduction studies","Nerve conduction studies (NCS) are FDA-approved diagnostic tests that use surface electrodes to stimulate peripheral nerves and assess nerve function. In this study, NCS findings will be compared to handheld quantitative neuromuscular monitor measurements.",[17,9,21],[40],{"name":41,"affiliation":5,"role":42},"Cliodhna Ashe, MD","PRINCIPAL_INVESTIGATOR",[44,49],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"Jessica Brickner","CONTACT","847-570-1197","jessica.brickner@endeavorhealth.org",{"name":50,"role":46,"phone":47,"phoneExt":30,"email":51},"Nia Moragne","nia.moragne@endeavorhealth.org",[53],{"facility":5,"status":54,"city":55,"state":56,"zip":57,"country":58,"countryCode":59,"cosmosGeoPoint":60,"geoPoint":65,"contacts":66},"RECRUITING","Evanston","Illinois","60201","United States","US",{"type":61,"coordinates":62},"Point",[63,64],-87.69006,42.04114,{"lat":64,"lon":63},[67,68,69],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},{"name":50,"role":46,"phone":47,"phoneExt":30,"email":51},{"name":41,"role":42,"phone":30,"phoneExt":30,"email":30},{"type":42,"investigatorFullName":71,"investigatorTitle":72,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Cliodhna Ashe","Clincial Professor","100053237","icu-connect-study-comparing-emg-in-healthy-volunteers-and-icu-patients-100053237",false,"NCT07699562","ICU CONNECT: Study Comparing EMG in Healthy Volunteers and ICU Patients.","ICU CONNECT Trial: A MultIcenter Comparison Cohort Trial EvalUating the Correlation Between nOn-iNvasive EMG and iNvasive EMG in Healthy Volunteers and Critically Ill PaTients","ICU CONNECT","Inclusion Criteria:\n\n* Cohort 1: Healthy volunteers\n\nInclusion criteria:\n\n* Subjects must be \\> 18 years old and \\\u003C 90 years old.\n* Subjects must consent to participate. Cohort 2: Non-intubated critically ill patients\n\nInclusion criteria:\n\n* Subjects may be male or female.\n* Subjects must be \\> 18 years old and \\\u003C 90 years old.\n* Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves).\n\nCohort 3: Intubated critically ill patients\n\nInclusion criteria:\n\n* Subjects may be male or female.\n* Subjects must be \\> 18 years old and \\\u003C 90 years old.\n* Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves).\n* For the Subjects in the ICU that are intubated, they must be planned to be intubated for at least 24 hours.\n* Subjects must be intubated for no longer than ≥ 72 hours before enrollment.\n\nExclusion Criteria:\n\n* Cohort 1: Healthy volunteers\n\nExclusion criteria:\n\n* Subjects with previous paralysis or neuromuscular disease.\n* Subjects with spinal cord or brain injuries that impact motor function.\n* Subjects with an allergy to clinical adhesive or hydrogel. Cohort 2: Non-intubated critically ill patients\n\nExclusion criteria:\n\n* Subjects with previous paralysis or neuromuscular diseases.\n* Subjects with previous peripheral nerve injuries to the tested limbs.\n* Subjects with spinal cord or brain injuries (including stroke) that impact motor function.\n* Subjects without a POA or next of kin for those patients that are unable to consent themselves.\n* Subjects with an allergy to clinical adhesive or hydrogel. Cohort 3: Intubated critically ill patients\n\nExclusion criteria:\n\n* Subjects with previous paralysis or neuromuscular disease\n* Subjects with previous peripheral nerve injuries to the tested limbs.\n* Subjects with spinal cord or brain injuries that impact motor function.\n* Subjects without a POA or next of kin for those patients that are in the intubated arm.\n* Subjects with intubations expected to last less than 24 hours.\n* Subjects who have already been intubated for \\> 72 hours.\n* Subjects with an allergy to clinical adhesive or hydrogel.",true,"ALL","18 Years","90 Years",{"count":86,"type":87},24,"ESTIMATED","INTERVENTIONAL",[90],"NA","This study is testing whether a non-invasive nerve monitoring device (TetraGraph) can accurately detect early signs of ICU-acquired weakness by comparing readings from the device with standard nerve conduction\u002FEMG tests done by a specialist to see if they match. They will focus on muscle response signals in the hand and leg over about 10 days in three groups: healthy volunteers, ICU patients who are not on ventilators, and ICU patients who are on ventilators.",[93],"ICU Acquired Weakness","2026-07-07",{"date":96,"type":97},"2026-07-13","ACTUAL",{"date":99,"type":87},"2026-06",{"date":101,"type":87},"2027-09",{"name":5,"class":6},1]