[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558404":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":32,"responsibleParty":58,"collaborators":60,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":20,"enrollmentInfo":73,"targetDuration":20,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":35,"whyStopped":20,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"Centre Jean Perrin","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"constitutional genetic analysis","EXPERIMENTAL","Constitutional genetic exome analysis will be performed on the blood sample. If necessary, an analysis on a second independent sample (jugal smear) will be carried out if a probably pathogenic or pathogenic variant in a hereditary cancer predisposition gene is identified.",[13],"Genetic: Constitutional exome analysis",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"GENETIC","Constitutional exome analysis","For each patient included:\n\n* A family tree is drawn up, reporting personal and family histories of cancer. The patient's anatomopathological reports, related to his or her tumor lesions, are retrieved, in order to confirm\u002Fclarify individual or family diagnoses.\n* A blood sample and a jugal smear are taken to enable constitutional genetic exome analysis for research purposes.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Mathis LEPAGE, Dr","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Angeline GINZAC COUVÉ","CONTACT","0473278005","+33","angeline.ginzac@clermont.unicancer.fr",[33],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"Centre Jean PERRIN","RECRUITING","Clermont-Ferrand","Puy-de-Dôme","63011","France","FR",{"type":42,"coordinates":43},"Point",[44,45],3.08682,45.77969,{"lat":45,"lon":44},[48,49,51,54,56],{"name":27,"role":28,"phone":20,"phoneExt":20,"email":20},{"name":50,"role":24,"phone":20,"phoneExt":20,"email":20},"Mathis LEPAGE, DR",{"name":52,"role":53,"phone":20,"phoneExt":20,"email":20},"Xavier DURANDO, Pr","SUB_INVESTIGATOR",{"name":55,"role":53,"phone":20,"phoneExt":20,"email":20},"Mathilde GAY-BELLILE, Dr",{"name":57,"role":53,"phone":20,"phoneExt":20,"email":20},"Mathias CAVAILLÉ, Dr",{"type":59,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR",[61],{"name":62,"class":63},"Association Nationale des Patients atteints de cancers de l'oeil (A.N.P.A.C.O.)","UNKNOWN","100558404","identification-of-new-candidate-genes-for-hereditary-predisposition-to-uveal-melanoma-100558404",false,"NCT06550674","Identification of New Candidate Genes for Hereditary Predisposition to Uveal Melanoma","IGCMU","Inclusion Criteria:\n\n* Patient with a personal history of uveal melanoma (newly diagnosed, under treatment or in follow-up)\n* Enrolled in or benefiting from a social security scheme\n\nExclusion Criteria:\n\n* Causal pathogenic variation identified in BAP1 or MBD4\n* Patient does not consent to constitutional genetic analysis for diagnostic purposes\n* Patient not consenting to a constitutional genetic analysis for research purposes\n* Pregnant and breast-feeding women\n* Patients under guardianship or trusteeship","ALL","18 Years",{"count":74,"type":75},50,"ESTIMATED","INTERVENTIONAL",[78],"NA","Only 20% of familial uveal melanomas are explained by a hereditary predisposition, implying the presence of as yet unknown hereditary predispositions. This hypothesis is reinforced by epidemiological studies revealing an excess risk of prostate cancer, thyroid cancer and leukemia in patients who have developed uveal melanoma, even though these cancers are not part of the tumor spectrum of known hereditary predispositions to uveal melanoma (BAP1, MBD4). The identification of new candidate genes, once validated, would enable us to offer these families appropriate surveillance.",[81],"Uveal Melanoma",[83,84,85],"uveal melanoma","hereditary predisposition","candidate genes identification","2026-03-17",{"date":88,"type":89},"2026-03-19","ACTUAL",{"date":91,"type":89},"2024-10-29",{"date":93,"type":75},"2028-04",{"name":5,"class":6},1]