[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630762":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":48,"centralContacts":52,"locations":60,"responsibleParty":78,"collaborators":35,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":35,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":104,"whyStopped":35,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},{"fullName":5,"class":6},"Laval University","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"125 g per 2,380 kcal per day of a soy-based pudding (i.e., yogurt-free diet);","PLACEBO_COMPARATOR","The trial will consist of 4 predetermined diets, each lasting 7 days and separated by a 1-week washout period. The 4 diets will be based on a dairy-free background diet reflecting high adherence to Canada's food guide. In the yogurt-free control diet, the diet will include 125 g per 2,380 kcal per day of a soy-based pudding.",[13],"Other: Yogurt-free diet",{"label":15,"type":16,"description":17,"interventionNames":18},"90 g per 2,380 kcal per day of yogurt (0.5 reference serving of yogurt per 2,380 kcal per day)","EXPERIMENTAL","The trial will consist of 4 predetermined diets, each lasting 7 days and separated by a 1-week washout period. The 4 diets will be based on a dairy-free background diet reflecting high adherence to Canada's food guide. In the low yogurt-diet, the diet will include 90 g per 2,380 kcal per day of yogurt (i.e., 0.5 reference serving of yogurt per 2,380 kcal per day).",[19],"Other: Low-yogurt diet",{"label":21,"type":16,"description":22,"interventionNames":23},"175 g per 2,380 kcal per day of yogurt (1 reference serving of yogurt per 2,380 kcal per day)","The trial will consist of 4 predetermined diets, each lasting 7 days and separated by a 1-week washout period. The 4 diets will be based on a dairy-free background diet reflecting high adherence to Canada's food guide. In the low yogurt-diet, the diet will include 175 g per 2,380 kcal per day of yogurt (1 reference serving of yogurt per 2,380 kcal per day).",[24],"Other: Moderate-yogurt diet",{"label":26,"type":16,"description":27,"interventionNames":28},"350 g per 2,380 kcal per day of yogurt (2 reference servings per 2,380 kcal per day).","The trial will consist of 4 predetermined diets, each lasting 7 days and separated by a 1-week washout period. The 4 diets will be based on a dairy-free background diet reflecting high adherence to Canada's food guide. In the low yogurt-diet, the diet will include 350 g per 2,380 kcal per day of yogurt (2 reference servings per 2,380 kcal per day).",[29],"Other: High-yogurt diet",[31,36,40,44],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Yogurt-free diet","During 6 days, participants will receive a fully-controlled dairy-free background diet reflecting high adherence to Canada's food guide. The diet will be complemented by 125 g per 2,380 kcal per day of a soy-based pudding.\n\nOn day 7, participants will undergo an acute mixed-meal test to inform on time-responsiveness of the yogurt biomarkers. After a 12-hour fast, participants will arrive at INAF at 7:30 AM. The test meal will consist of a breakfast smoothie containing the same soy-based pudding provided daily during the preceding days. Plasma samples will be collected at baseline (fasting) and 1, 2, 4, and 6 hours post-meal.",[9],null,{"type":6,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"Low-yogurt diet","During 6 days, participants will receive a fully-controlled dairy-free background diet reflecting high adherence to Canada's food guide. The diet will be complemented by 90 g per 2,380 kcal per day of yogurt (i.e., 0.5 reference serving of yogurt per 2,380 kcal per day).\n\nOn day 7, participants will undergo an acute mixed-meal test to inform on time-responsiveness of the yogurt biomarkers. After a 12-hour fast, participants will arrive at INAF at 7:30 AM. The test meal will consist of a breakfast smoothie containing the same yogurt provided daily during the preceding days. Plasma samples will be collected at baseline (fasting) and 1, 2, 4, and 6 hours post-meal.",[15],{"type":6,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"Moderate-yogurt diet","During 6 days, participants will receive a fully-controlled dairy-free background diet reflecting high adherence to Canada's food guide. The diet will be complemented by 175 g per 2,380 kcal per day of yogurt (i.e., 1 reference serving of yogurt per 2,380 kcal per day).\n\nOn day 7, participants will undergo an acute mixed-meal test to inform on time-responsiveness of the yogurt biomarkers. After a 12-hour fast, participants will arrive at INAF at 7:30 AM. The test meal will consist of a breakfast smoothie containing the same yogurt provided daily during the preceding days. Plasma samples will be collected at baseline (fasting) and 1, 2, 4, and 6 hours post-meal.",[21],{"type":6,"name":45,"description":46,"armGroupLabels":47,"otherNames":35},"High-yogurt diet","During 6 days, participants will receive a fully-controlled dairy-free background diet reflecting high adherence to Canada's food guide. The diet will be complemented by 350 g per 2,380 kcal per day of yogurt (i.e., 2 reference servings per 2,380 kcal per day).\n\nOn day 7, participants will undergo an acute mixed-meal test to inform on time-responsiveness of the yogurt biomarkers. After a 12-hour fast, participants will arrive at INAF at 7:30 AM. The test meal will consist of a breakfast smoothie containing the same yogurt provided daily during the preceding days. Plasma samples will be collected at baseline (fasting) and 1, 2, 4, and 6 hours post-meal.",[26],[49],{"name":50,"affiliation":5,"role":51},"Jean-Philippe Drouin-Chartier, PhD","PRINCIPAL_INVESTIGATOR",[53,57],{"name":50,"role":54,"phone":55,"phoneExt":35,"email":56},"CONTACT","418-656-2131","jean-philipe.drouin-chartier@pha.ulaval.ca",{"name":58,"role":54,"phone":55,"phoneExt":35,"email":59},"Valérie Guay, MSc","valerie.guay@fsaa.ulaval.ca",[61],{"facility":62,"status":35,"city":63,"state":64,"zip":65,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Institute on nutrition and functional foods, Laval University","Québec","Quebec","G1V0A?","Canada","CA",{"type":69,"coordinates":70},"Point",[71,72],-71.21454,46.81228,{"lat":72,"lon":71},[75,76,77],{"name":50,"role":54,"phone":55,"phoneExt":35,"email":56},{"name":58,"role":54,"phone":55,"phoneExt":35,"email":59},{"name":50,"role":51,"phone":35,"phoneExt":35,"email":35},{"type":51,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Jean-Philippe Drouin-Chartier","Professor","100630762","identification-of-objective-metabolomics-based-biomarkers-of-yogurt-consumption-100630762",false,"NCT07491887","Identification of Objective Metabolomics-based Biomarkers of Yogurt Consumption","YOGBIO","Inclusion criteria:\n\n* age: 18-70 years;\n* BMI: 18-40 kg\u002Fm²;\n* willingness to consume plain yogurt daily for 3 weeks;\n* for coffee\u002Ftea consumers, willingness to consume these beverages without added milk, cream or sugar for 4 weeks.\n\nExclusion criteria:\n\n* lactose intolerance; blood donation within 2 months; severe chronic illness or ongoing treatment for conditions such as infections, autoimmune diseases, cancer, type 2 diabetes, Crohn's disease, celiac disease, hepatic or renal diseases;\n* history of severe cancer, cardiovascular disease or bariatric surgery;\n* unstable body weight for 3 months;\n* illicit drug use or alcoholism; tobacco\u002Fcannabis smoking\u002Fvaping (ensuring no day-to-day fluctuations and objective reporting of consumption is too complex);\n* allergies or aversions to components of the diets.",true,"ALL","18 Years","70 Years",{"count":93,"type":94},16,"ESTIMATED","INTERVENTIONAL",[97],"NA","Substantial evidence links yogurt consumption to a lower risk of type 2 diabetes (T2D). However, the existing evidence is derived exclusively from prospective cohort studies relying on self-reported dietary questionnaires, which-despite being validated-are subject to random and systematic errors that may compromise evidence quality and hinder regulatory approval.\n\nThe project aims to discover and validate biomarkers of yogurt intake.\n\nThe investigators will conduct a randomized, crossover, dose-response feeding trial involving 16 generally healthy adult participants (8 females, 8 males). The trial will include four 7-day diet periods, each separated by a 1-week washout. All diets will be based on a dairy-free background and supplemented with one of the following: (a) 1 serving of soy-based pudding (no yogurt), (b) 0.5 serving of yogurt, (c) 1 serving of yogurt, or (d) 2 servings of yogurt per 2,380 kcal\u002Fday.\n\nOn the 7th day of each diet, participants will complete a mixed-meal test at INAF, consuming a smoothie containing the same yogurt dose as during the preceding days. Plasma samples collected in the postprandial state will be used to profile over 20,000 metabolites. Using artificial intelligence-based approaches, potential biomarkers of yogurt intake will be identified. These candidates will then be filtered using standard statistical methods to assess dose- and time-responsiveness, robustness, and biological plausibility. Biomarkers that meet all criteria will be considered validated indicators of yogurt intake.",[100],"Diet",[102,103],"yogurt","biomarker of food intake","NOT_YET_RECRUITING","2026-03-27",{"date":107,"type":108},"2026-04-02","ACTUAL",{"date":110,"type":94},"2026-03-23",{"date":112,"type":94},"2026-06-30",{"name":5,"class":6},1]