[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100569564":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":30,"locations":38,"responsibleParty":55,"collaborators":24,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":24,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Rutgers, The State University of New Jersey","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Excitatory TMS","EXPERIMENTAL","For condition 1a, 3600 pulses of 10-Hz TMS or 3600 pulses of cTBS. 10 Hz rTMS (110% RMT stimulation intensity; 10 Hz frequency; 5 s on and 26 s off; 3600 pulses per session; total duration of 40 min). cTBS (80% RMT, (3 pulses at 50 Hz with a repeated frequency of 5 Hz, 200 ms intervals, containing 1800 pulses, 60 second break, 1800 pulses; total duration of 5 minutes).",[13],"Device: Transcranial Magnetic Stimulation",{"label":15,"type":10,"description":16,"interventionNames":17},"Inhibitory TMS","For condition 1b, 600 or 1200 pulses of iTBS. iTBS will be administered at 80% of each participant's RMT in a burst-firing pattern (3 pulses at 50 Hz) for a 2 s train, followed by an 8 s period of rest. Across sessions, participants will receive one of two iTBS protocols (randomized): 600 pulses (190 s) or 1200 pulses (570 s).",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","Transcranial Magnetic Stimulation","TMS will be delivered using a robotic neuronavigation system (Smartmove, ANT). Stimulation intensity will be standardized. Stimulation will be delivered to the L-DLPFC using a active\u002Fplacebo figure-8 coil and a magventure TMS device.",[9,15],null,[26],{"name":27,"affiliation":28,"role":29},"Travis E Baker, PhD","Rutgers University","PRINCIPAL_INVESTIGATOR",[31,35],{"name":27,"role":32,"phone":33,"phoneExt":24,"email":34},"CONTACT","973-353-5485","travis.e.baker@rutgers.edu",{"name":36,"role":32,"phone":37,"phoneExt":24,"email":34},"Emily Zhang","973-353-3509",[39],{"facility":40,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Rutgers University - Newark","RECRUITING","Newark","New Jersey","07102","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-74.17237,40.73566,{"lat":51,"lon":50},[54],{"name":27,"role":32,"phone":33,"phoneExt":24,"email":34},{"type":29,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Travis Baker, PhD","Associate Professor","100569564","identify-the-optimal-tms-pulse-protocol-to-modulate-reward-activity-100569564",false,"NCT06695884","Identify the Optimal TMS Pulse Protocol to Modulate Reward Activity","Determining the Optimal Pulse Protocol for TMS Induced Change in Reward Positivity","Inclusion Criteria:\n\n1. Nicotine dependent individuals (according to the Alcohol, Smoking and Substance Involvement Screening Test nicotine dependence score).\n2. Be between the ages of 18 and 55 years old.\n3. Not received substance abuse treatment within the previous 30 days.\n4. Be in stable mental and physical health.\n5. If female, test non-pregnant.\n6. No evidence of focal or diffuse brain lesion on MRI.\n7. Be willing to provide informed consent.\n8. Be able to comply with protocol requirements and likely to complete all study procedures.\n\nExclusion Criteria:\n\n1. Contraindication to MRI (e.g., presence of metal in the skull, orbits or intracranial cavity, claustrophobia).\n2. Contraindication to rTMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for \\> 15 minutes, implanted electronic device, metal in the head, or pregnancy).\n3. History of autoimmune, endocrine, viral, or vascular disorder affecting the brain.\n4. History or MRI evidence of neurological disorder that would lead to local or diffuse brain lesions or significant physical impairment.\n5. Life time history of mental disorders such as: Bipolar Affective disorder (BPAD), Schizophrenia, Post-traumatic Stress disorder (PTSD) or Dementia or Major Depression.\n6. uninterruptable central nervous system medication","ALL","18 Years","55 Years",{"count":69,"type":70},42,"ESTIMATED","INTERVENTIONAL",[73],"NA","The primary goal will be to identify the optimal pulse protocol by systematically measuring the efficacy of various theta burst stimulation and repetitive rTMS protocols to increase and decrease the reward positivity in dependent smokers. The secondary objective will be to measure the protocols' effectiveness to increase decision-making capacity using the probabilistic selection task (PST). The third objective will be to specifically assess whether the TMS targets has a differential impact on state levels of craving relative to baseline (Tobacco Craving Questionnaire \\[TCQ\\]. The investigators plan to accomplish these three objectives using a randomized, controlled experiment involving 2 sessions.",[76],"Nicotine Use Disorder",[78,79,80,81],"transcranial magnetic stimulation","reward processing","EEG","smoking","2025-11-14",{"date":84,"type":85},"2025-11-18","ACTUAL",{"date":87,"type":85},"2024-08-01",{"date":89,"type":70},"2026-08-31",{"name":5,"class":6},1]