[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100585077":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":31,"centralContacts":37,"locations":43,"responsibleParty":61,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":65,"sex":69,"minAge":70,"maxAge":10,"enrollmentInfo":71,"targetDuration":10,"studyType":74,"phases":10,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":45,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Controls",null,"o No past or current psychiatric or cognitive disorder.",[13],"Other: Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.",{"label":15,"type":10,"description":16,"interventionNames":17},"Major Depressive Disorder","* Diagnosis of major depressive disorder, confirmed through clinical evaluation.\n* No history of bipolar disorder or psychotic symptoms.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Bipolar Disorder","o Diagnosis of bipolar disorder I or II, confirmed through clinical evaluation.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Mild Cognitive Impairment (MCI)","* Pre-existing clinical diagnosis of mild cognitive impairment, supported by neuropsychological testing and\u002For MRI, PET scan data.\n* No history of major psychiatric disorders, such as major depression, bipolar disorder or schizophrenia.",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"Observational assessment using functional near-infrared spectroscopy (fNIRS), a noninvasive, portable brain imaging tool that measures changes in brain blood flow and oxygen levels.","Functional near-infrared spectroscopy (fNIRS) transcutaneously measures changes in oxyhemoglobin in the prefrontal cortex using light detection. It is designed to measure variations in cerebral hemodynamics on a real-time basis by radiating a near light beam, at two wavelengths of 780nm and 850nm of laser, into the cerebral cortex.\n\nParticipants will undergo a one-time functional near-infrared spectroscopy (fNIRS) procedure to measure cerebral hemodynamic patterns.\n\n* Resting-State Measurement: 5-10 min resting-state scans.\n* Task-Based Measurement: Participants will be shown an instruction video. Participants will complete a Verbal Fluency Task (VFT) during the fNIRS scan (15-20 min).\n* During the fNIRS scan, optional basic vital signs will be measured using respiratory belts, photoplethysmography (PPG), and electrocardiogram (ECG).\n* Each participant will complete 3 sets of resting-state and task-based measurements.\n\nTotal estimated time for fNIRS assessment: 45-60 min.",[19,9,15,23],[32,35],{"name":33,"affiliation":5,"role":34},"Maria I. Lapid, M.D.","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":34},"Paul H. Min, Ph.D.",[38],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":42},"Sarah M. Williams","CONTACT","507-422-2972","Williams.Sarah2@mayo.edu",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Rochester","Minnesota","55905","United States","US",{"type":52,"coordinates":53},"Point",[54,55],-92.4699,44.02163,{"lat":55,"lon":54},[58,59,60],{"name":39,"role":40,"phone":41,"phoneExt":10,"email":10},{"name":33,"role":34,"phone":10,"phoneExt":10,"email":10},{"name":36,"role":34,"phone":10,"phoneExt":10,"email":10},{"type":34,"investigatorFullName":33,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Principal Investigator","100585077","identifying-cerebral-hemodynamic-patterns-in-mood-disorders-and-mild-cognitive-impairment-a-functional-near-infrared-spectroscopy-fnirs-study-100585077",false,"NCT06897670","Identifying Cerebral Hemodynamic Patterns in Mood Disorders and Mild Cognitive Impairment: A Functional Near-Infrared Spectroscopy (fNIRS) Study","Inclusion Criteria\n\nGeneral Inclusion Criteria (across all diagnostic groups):\n\n* 18 years and older\n* Ability to provide written informed consent\n* Adequate cognitive and language abilities to understand and complete study tasks, including clinical assessments and fNIRS procedures\n* Confirmed clinical diagnosis of major depressive disorder, bipolar disorder, or mild cognitive impairment (MCI)\n* Stable psychiatric or cognitive condition, without acute episodes requiring immediate intervention\n\nSpecific Inclusion Criteria (for diagnostic groups):\n\n* Healthy control\n\n  o No past or current psychiatric or cognitive disorder\n* Major depressive disorder (MDD):\n\n  * Diagnosis of major depressive disorder, confirmed through clinical evaluation.\n  * No history of bipolar disorder or psychotic symptoms.\n* Bipolar disorder:\n\n  o Diagnosis of bipolar disorder I or II, confirmed through clinical evaluation.\n* Mild Cognitive Impairment (MCI):\n\n  * Pre-existing clinical diagnosis of mild cognitive impairment, supported by neuropsychological testing and\u002For MRI, PET scan data.\n  * No history of major psychiatric disorders, such as major depression, bipolar disorder or schizophrenia.\n\nExclusion Criteria\n\nGeneral Exclusion Criteria (across all diagnostic groups):\n\n* Active primary psychotic or substance use disorders (except nicotine dependence) within the past year\n* Any severe or unstable medical condition that could interfere with participation or data collection\n* Any active neurological condition (including seizure disorder, traumatic brain injury, stroke) that could affect cognitive functioning or brain imaging results\n* Inability to comply with study procedures, including cognitive testing, fNIRS assessment, or other assessments required by the protocol\n* Pregnant women will be excluded due to potential physiological changes that could affect study outcomes\n\nSpecific Exclusion Criteria (for diagnostic groups):\n\n* Healthy control\n\n  o Any past or current psychiatric or cognitive disorder\n* Major depressive disorder (MDD):\n\n  * Diagnosis of bipolar disorder or schizophrenia.\n  * Brain stimulation therapy within the past 3 months.\n* Bipolar disorder:\n\n  o Diagnosis of schizophrenia or schizoaffective disorder.\n* Mild Cognitive Impairment (MCI):\n\n  * Diagnosis of dementia.\n  * Significant cognitive impairment preventing understanding or completion of study tasks.","ALL","18 Years",{"count":72,"type":73},200,"ESTIMATED","OBSERVATIONAL","The purpose of this research is to measure brain activity in individuals with mood disorders and memory problems using a simple, safe, and noninvasive method called functional near-infrared spectroscopy (fNIRS). By comparing brain activity across different groups and relating it to symptom severity, this study aims to improve our understanding of how these conditions affect the brain.",[15,19,77],"Mild Cognitive Impairment",[79,80,81,82],"functional near-infrared spectroscopy","diagnostics","mood disorders","mild cognitive impairment","2026-04-24",{"date":85,"type":86},"2026-04-29","ACTUAL",{"date":88,"type":86},"2025-03-26",{"date":90,"type":73},"2028-03-30",{"name":5,"class":6},1]