[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603278":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":10,"locations":10,"responsibleParty":11,"collaborators":13,"id":16,"slug":17,"hasResults":18,"nctId":19,"briefTitle":20,"officialTitle":20,"acronym":21,"eligibilityCriteria":22,"healthyVolunteers":18,"sex":23,"minAge":24,"maxAge":10,"enrollmentInfo":25,"targetDuration":10,"studyType":28,"phases":10,"briefSummary":29,"conditions":30,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":10},{"fullName":5,"class":6},"Guy's and St Thomas' NHS Foundation Trust","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"Men undergoing Androgen Deprivation Therapy for the treatment of prostate cancer",null,{"type":12,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[14],{"name":15,"class":6},"King's College London","100603278","identifying-fundamental-mechanisms-of-skeletal-muscle-ageing-in-older-men-undergoing-androgen-deprivation-therapy-a-feasibility-study-100603278",false,"NCT07134439","Identifying Fundamental Mechanisms of Skeletal Muscle Ageing in Older Men Undergoing Androgen Deprivation Therapy: a Feasibility Study","MASS-ADT","Inclusion Criteria:\n\n* Age ≥65 years old at time of recruitment\n* Able to provide informed consent to participate\n* Known prostate cancer due to be initiated on ADT for the first time (with or without Androgen Receptor Targeted Agents (ARTA) or radiotherapy), or initiated within two weeks prior to recruitment.\n* Individuals involved in other research will be eligible to participate so long as the other research does not involve potential changes to the standard ADT care the participant will be receiving and does not involve an intervention aimed at reducing the muscle atrophy associated with ADT.\n\nExclusion Criteria:\n\n* Systemic anti-cancer therapy within one year of recruitment (for prostate cancer or any other concomitant cancer)\n* Planned surgery (not including eye surgery or other minor surgery) within six months of ADT\n* Any other condition previous or current which, in the judgement of the responsible clinician, is likely to interfere with the trial \u002F assessments.\n* Lacks capacity to consent\n\nExclusion criteria for those consenting to optional muscle biopsy:\n\n* On treatment with clopidogrel, high-dose aspirin, dipyridamole or anticoagulants\n* Known bleeding disorder or platelets \\\u003C75x103\u002FmL","MALE","65 Years",{"count":26,"type":27},20,"ESTIMATED","OBSERVATIONAL","To find out whether it is possible to run a study looking at the underlying markers of ageing in muscle quality and quantity in men receiving Androgen Deprivation Therapy for prostate cancer treatment.\n\nTo determine the feasibility of conducting an observational study examining the association of fundamental biological markers of ageing with changes in body composition and skeletal muscle morphology following ADT in older men undergoing prostate cancer treatment.",[31,32,33,34],"Sarcopenia","Prostate Cancer","Muscle Atrophy","Androgen Deprivation Therapy","NOT_YET_RECRUITING","2025-08-14",{"date":38,"type":39},"2025-08-21","ACTUAL",{"date":41,"type":27},"2025-09",{"date":43,"type":27},"2026-12",{"name":5,"class":6}]