[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620444":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":23,"locations":28,"responsibleParty":52,"collaborators":10,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":10,"studyType":67,"phases":10,"briefSummary":68,"conditions":69,"keywords":72,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},{"fullName":5,"class":6},"National Institutes of Health Clinical Center (CC)","NIH",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Non obstructive azoospermia",null,"Men aged 18 and older who have no semen in the ejaculate with no evidence of pathologic transport of sperm",{"label":13,"type":10,"description":14,"interventionNames":10},"Oligospermia","Men aged 18 or older who have a concentration less than 5 million\u002FmL in ejaculate with no other known cause of oligospermia.",{"label":16,"type":10,"description":17,"interventionNames":10},"Primary ovarian insufficiency","Women who have been diagnosed with primary ovarian insufficiency",[19],{"name":20,"affiliation":21,"role":22},"Todd S Macfarlan, M.D.","Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)","PRINCIPAL_INVESTIGATOR",[24],{"name":20,"role":25,"phone":26,"phoneExt":10,"email":27},"CONTACT","(301) 594-8496","MacfarlanLab@mail.nih.gov",[29,43],{"facility":30,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":10},"National Institutes of Health Clinical Center (Remote and In-Person)","RECRUITING","Bethesda","Maryland","20892","United States","US",{"type":38,"coordinates":39},"Point",[40,41],-77.10026,38.98067,{"lat":41,"lon":40},{"facility":44,"status":31,"city":45,"state":33,"zip":46,"country":35,"countryCode":36,"cosmosGeoPoint":47,"geoPoint":51,"contacts":10},"Shady Grove Fertility","Rockville","20850",{"type":38,"coordinates":48},[49,50],-77.15276,39.084,{"lat":50,"lon":49},{"type":53,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100620444","identifying-genome-variants-in-non-obstructive-azoospermia-noa-or-primary-ovarian-insufficiency-poi-100620444",false,"NCT07357701","Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)","Identifying Genome Variants and Evaluating PRDM9 and piRNA Clusters as Candidates for Infertility in a Cohort of Individuals With Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI)","* INCLUSION CRITERIA:\n\nIn order to be eligible to participate in this study, an individual must meet all of the following criteria:\n\n1. Provision of signed and dated informed consent form\n2. Stated willingness to comply with all study procedures and availability for the duration of the study\n3. Adult male or female, of reproductive age\n4. Clinical diagnosis of NOA, oligospermia, or POI.\n5. In good general health with no medical history suspected as the cause of infertility.\n\nEXCLUSION CRITERIA:\n\nAn individual who meets any of the following criteria will be excluded from participation in this study:\n\n1. Current use of medications that may cause infertility (chemotherapy, etc.)\n2. Pregnant or lactating\n3. Medical history indicating known common cause of infertility such as karyotype anomalies, Y-chromosome microdeletions, known monogenic causes, or other medical history affecting gamete production (i.e. injuries, surgical operations, infections, radiation, or chemotherapy).","ALL","18 Years","100 Years",{"count":65,"type":66},500,"ESTIMATED","OBSERVATIONAL","Background:\n\nInfertility affects 1 in 6 people. Often, the causes of infertility are unknown. Treatments are successful in only about 50% of cases. Infertility caused by non obstructive azoospermia in males and primary ovarian insufficiency in females can have genetic causes. Researchers want to learn more about these genes.\n\nObjective:\n\nTo identify genes that may cause infertility.\n\nEligibility:\n\nAdult men and women with non-obstructive azoospermia (NOA) or primary ovarian insufficiency (POI) of unknown cause.\n\nDesign:\n\nParticipants will provide a saliva sample. A kit will be sent to their home. The kit will contain a collection tube and a cotton swab. They will swirl the swab inside their mouth and then seal it in the tube. They will mail the tube back to the researchers.\n\nMale participants who are having a procedure done to collect tissue from their testes may opt to have leftover tissue provided to study researchers. This tissue would otherwise have been discarded. No new procedures will be performed just for this study.\n\nData may be collected from participants medical records.",[70,71,13],"Primary Ovarian Insufficiency","Azoospermia",[73,74,75,76,77,78,79,70,80],"NOA","POI","Premature Ovarian Insufficiency","oligospermia","azoospermia","diminished ovarian reserve","nonobstructive azoospermia","Infertility","2026-03-13",{"date":83,"type":84},"2026-03-16","ACTUAL",{"date":86,"type":84},"2026-03-11",{"date":88,"type":66},"2031-01-01",{"name":21,"class":6},2]