[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593536":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":34,"centralContacts":42,"locations":48,"responsibleParty":65,"collaborators":34,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":34,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":34,"enrollmentInfo":78,"targetDuration":34,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":50,"whyStopped":34,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"National Taiwan University Hospital","OTHER",[8,14,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Flow of 40L\u002Fmin","ACTIVE_COMPARATOR","Setting HFNC flow at 40 L\u002Fmin",[13],"Other: Flow of 40L\u002Fmin",{"label":15,"type":16,"description":17,"interventionNames":18},"Peak tidal inspiratory flow (PTIF) guided","EXPERIMENTAL","Setting HFNC flow at 5 L\u002Fmin above the peak tidal inspiratory flow (PTIF), up to a maximum of 60 L\u002Fmin.",[19],"Other: Peak tidal inspiratory flow (PTIF) guided",{"label":21,"type":16,"description":22,"interventionNames":23},"PaO2\u002FFiO2 ratio guided","Setting HFNC flow according to P\u002FF ratio prior to extubation. Flow will be set at 60, 50 40 L\u002Fmin if P\u002FF ratio \\\u003C250 mmHg, 250-300 mmHg and \\>300 mmHg, respectively.",[24],"Other: PaO2\u002FFiO2 ratio guided",{"label":26,"type":16,"description":27,"interventionNames":28},"Flow of 60L\u002Fmin","Setting HFNC flow at 60 L\u002Fmin",[29],"Other: Flow of 60L\u002Fmin",[31,35,37,39],{"type":6,"name":9,"description":32,"armGroupLabels":33,"otherNames":34},"Setting flow rate at 40L\u002Fmin",[9],null,{"type":6,"name":15,"description":17,"armGroupLabels":36,"otherNames":34},[15],{"type":6,"name":21,"description":22,"armGroupLabels":38,"otherNames":34},[21],{"type":6,"name":26,"description":40,"armGroupLabels":41,"otherNames":34},"Setting flow rate at 60L\u002Fmin",[26],[43],{"name":44,"role":45,"phone":46,"phoneExt":34,"email":47},"Sheng-Yuan Ruan, MD, PhD","CONTACT","886223123456","syruan@ntu.edu.tw",[49],{"facility":5,"status":50,"city":51,"state":34,"zip":34,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Taipei","Taiwan","TW",{"type":55,"coordinates":56},"Point",[57,58],121.52639,25.05306,{"lat":58,"lon":57},[61],{"name":62,"role":45,"phone":63,"phoneExt":34,"email":64},"Research Ethics Committee of NTUH","886223951950","ntuhrec@ntuh.gov.tw",{"type":66,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":34,"oldOrganization":34},"PRINCIPAL_INVESTIGATOR","National Taiwan University Clinical Trial Center","Sheng-Yuan Ruan, MD","100593536","identifying-the-best-flow-setting-strategy-for-high-flow-nasal-cannula-100593536",false,"NCT07007715","Identifying the Best Flow Setting Strategy for High-Flow Nasal Cannula","Optimizing High-flow Nasal Cannula Settings: Comparing Different Flow Approaches and Exploring Physiological Phenotyping With End-expiratory Lung Volume, Peak Tidal Inspiratory Flow and Oxygen Demand","Inclusion Criteria:\n\n* Intubated and receiving mechanical ventilation for more than 24 hours\n* Ready for planned extubation after passing a spontaneous breathing trial\n* PaO2\u002FFiO2 \\\u003C350 mmHg on the day of extubation\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* On do-not-reintubate code\n* Pregnant women\n* Having tracheostomies\n* Infeasibility of using HFNC\n* Planning to use preventive NIV after extubation by the primary care team\n* Life expectancy less than one month","ALL","18 Years",{"count":79,"type":80},480,"ESTIMATED","INTERVENTIONAL",[83],"NA","The goal of this randomized trial is to compare four different flow-setting approaches for post-extubation use of high-flow nasal cannula (HFNC). Selecting the appropriate flow rate when initiating HFNC oxygen therapy is both crucial and challenging for clinicians, as the physiological benefits of HFNC depend significantly on the flow rate. To date, there are no guidelines or consensus on flow-rate setting and weaning for HFNC oxygen therapy.\n\nThe investigators hypothesized that physiological marker-guided flow setting using peak tidal inspiratory flow (PTIF) or PaO₂\u002FFiO₂ ratios lead to better extubation outcomes as compared to empirical flow setting of 40 L\u002Fmin or 60 L\u002Fmin.\n\nParticipants will be randomly assigned to one of four study groups with different flow setting strategies summarized as follows: (1) Setting flow at 40 L\u002Fmin, (2) Setting flow at 5 L\u002Fmin above the peak tidal inspiratory flow, up to a maximum of 60 L\u002Fmin. (3) Setting flow according to P\u002FF ratio prior to extubation. Flow will be set at 60, 50 40 L\u002Fmin if P\u002FF ratio \\\u003C250 mmHg, 250-300 mmHg and \\>300 mmHg, respectively. (4) Setting flow at 60 L\u002Fmin.",[86,87],"Extubation Readiness","Respiratory Failure With Hypoxia",[89,90,91,92],"flow rate","high flow nasal cannula","peak inspiratory flow","reintubation","2025-06-05",{"date":95,"type":96},"2025-06-06","ACTUAL",{"date":93,"type":96},{"date":99,"type":80},"2028-06-30",{"name":5,"class":6},1]