[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100422964":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":38,"responsibleParty":61,"collaborators":65,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":40,"whyStopped":10,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Politecnico di Milano","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Osteoporotic patients",null,"Osteoporotic patients, age \\> 18 years old",[13],"Procedure: Hip replacement surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"Non osteoporotic patients","Non osteoporotic patients, age \\> 18 years old",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"PROCEDURE","Hip replacement surgery","After hip replacement surgery the sponsor obtains femoral head samples for the study",[15,9],[25],{"name":26,"affiliation":27,"role":28},"Luigi Zagra","IRCCS Istituto Ortopedico Galeazzi","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Laura M Vergani","CONTACT","+393393758630","luigi.zagra@fastwebnet.it",{"name":36,"role":32,"phone":10,"phoneExt":10,"email":37},"Federica Buccino","federica.buccino@polimi.it",[39],{"facility":27,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"RECRUITING","Miano","Milano","20161","Italy","IT",{"type":47,"coordinates":48},"Point",[49,50],14.25339,40.88816,{"lat":50,"lon":49},[53,57],{"name":54,"role":32,"phone":55,"phoneExt":10,"email":56},"Elena M Cittera","0266214057","elena.cittera@grupposandonato.it",{"name":58,"role":32,"phone":59,"phoneExt":10,"email":60},"Sara Zacchetti","0266214048","sara.zacchetti@grupposandonato.it",{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Laura Maria Vergani","Professor",[66],{"name":67,"class":6},"Ospedale San Donato","100422964","image-guided-computational-and-experimental-analyses-of-fractured-patients-bone-gap-100422964",false,"NCT04787679","Image-guided Computational and Experimental Analyses of Fractured Patient's Bone (GAP)","GAP","Inclusion Criteria:\n\n* Age: \\>=18 years\n* primary hip replacement\n* Signature of informed consent\n* Patients who have a routine preoperative CT scan\n\nExclusion criteria:\n\n* Patients unrelated to the inclusion criteria of this study\n* Bone disease (non-osteoporotic) such as to invalidate sample analysis, including but not limited to genetic disorders and bone tumors\n* Patients with contralateral hip replacement and\u002For other synthetic means in the contralateral hip\n* Patients with synthesis devices in the hip of interest","ALL","18 Years",{"count":78,"type":79},52,"ESTIMATED","OBSERVATIONAL","Due to the increase in the average age of the population, the projections on the number of age-dependent bone fractures appear to be constantly increasing.\n\nThey are mainly due to bone pathologies, including osteoporosis. The latter leads to a reduction in bone mineral density and deterioration of the micro-architecture, with a consequent increase in bone fragility. However, the mechanisms of damage at the micro-scale have not yet been elucidated and there is no universally recognized damage criterion. Recent research has evaluated the importance of implementing computational models to study the influence of bone gaps, canaliculi and microporosities on the propagation of damage. These models need to be validated through experimental tests, still lacking, in particular on human bones, in the current scientific landscape. Once the experimental validation of computational models has been developed, it will be possible to introduce new fracture indices at the micro-scale, useful for a preventive diagnosis of osteoporosis.",[83,84],"Osteoporosis","Fragility Fracture",[86,87,88,89,90],"lacunae","damage models","micro-cracks","synchrotron","numerical models","2026-01-27",{"date":93,"type":94},"2026-01-29","ACTUAL",{"date":96,"type":94},"2020-11-09",{"date":98,"type":79},"2028-08-09",{"name":63,"class":6},1]