[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100630989":3},{"organization":4,"armGroups":7,"interventions":13,"overallOfficials":20,"centralContacts":24,"locations":31,"responsibleParty":49,"collaborators":19,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":19,"eligibilityCriteria":58,"healthyVolunteers":55,"sex":59,"minAge":60,"maxAge":19,"enrollmentInfo":61,"targetDuration":19,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":75,"whyStopped":19,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"University of California, Los Angeles","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Treatment","Treatment with GAE",[12],"Device: Embolization",[14],{"type":15,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Embolization","Genicular artery embolization",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Lucas Cusumano, MD","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Arshia Mian, BS","CONTACT","310-906-6028","ammian@mednet.ucla.edu",{"name":22,"role":27,"phone":19,"phoneExt":19,"email":19},[32],{"facility":5,"status":19,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Los Angeles","California","90095","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-118.24368,34.05223,{"lat":42,"lon":41},[45,46],{"name":26,"role":27,"phone":19,"phoneExt":19,"email":29},{"name":47,"role":27,"phone":19,"phoneExt":19,"email":48},"Saima Chaabane, PhD","SChabaane@mednet.ucla.edu",{"type":50,"investigatorFullName":51,"investigatorTitle":52,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Lucas R. Cusumano, MD","Interventional Radiologist, Assistant Clinical Professor","100630989","images-identifying-metabolic-imaging-association-with-genicular-artery-embolization-success-100630989",false,"NCT07494838","IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success","Inclusion Criteria:\n\n* Provided informed consent\n* Age ≥ 40 years\n* Ineligibility for or refusal of surgical management\n* Moderate-severe knee pain as determined by visual analog scale \\> 5 out of 10\n* Osteoarthritis based on X-ray. Kellgren-Lawrence score \\> 2 based on radiograph completed within 3 months of procedure date\n* Resistant\u002Ffailed some form of conservative treatment (e.g. NSAIDS\u002Fphysical therapy\u002Fsteroid joint injection\u002Fhyaluronic acid joint injection) for at least 3 months\n* Able to comply with all treatments and protocol follow-up visits\n\nExclusion Criteria:\n\n* Mild knee pain as determined by visual analog scale \\\u003C 5 out of 10\n* OA on knee radiograph resulting in greater than 20 degree varus or valgus angulation\n* Moderate loss of kidney function, define as estimated glomerular filtration rate of less than 45 mL\u002Fmin.\n* Significant arterial atherosclerosis that would limit selective angiography\n* History of fibromyalgia, autoimmune, or inflammatory disorder\n* History of any lumbar spine surgery, spine injections, or radicular pain in the extremity believed to originate from the spine\n* Allergy to iodinated contrast agents\n* Active infection or malignancy\n* Recent (within 12 months) or active cigarette use\n* Prior total or partial knee replacement in the subject knee\n* Active pregnancy\n* Uncorrectable bleeding diathesis\n* Presence of pacemakers, aneurysm clips, neurostimulators, or any other metal implant not compatible with PET\u002FMRI","ALL","40 Years",{"count":62,"type":63},25,"ESTIMATED","INTERVENTIONAL",[66],"NA","Several clinical trials on genicular artery embolization (GAE) show significant clinical benefit for the majority of patients. However, a proportion of patients do not benefit from GAE, and responses vary across individual patients. Changes in metabolic activity on non-invasive imaging may correlate with improvement in symptoms of knee osteoarthritis. This study will assess changes in metabolic uptake on a hybrid positron emission tomography\u002Fmagnetic resonance imaging (PET\u002FMRI) system in subjects undergoing GAE.",[69,70,71,72],"Knee Osteoarthritis","Knee Discomfort","Knee Pain Chronic","Knee Swelling Pain",[74],"GAE","NOT_YET_RECRUITING","2026-03-21",{"date":78,"type":79},"2026-03-27","ACTUAL",{"date":81,"type":63},"2026-06-30",{"date":83,"type":63},"2027-06-30",{"name":51,"class":6},1]