[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100573028":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":8,"locations":18,"responsibleParty":36,"collaborators":7,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":41,"sex":46,"minAge":47,"maxAge":7,"enrollmentInfo":48,"targetDuration":7,"studyType":51,"phases":7,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":21,"whyStopped":7,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Universitätsklinikum Hamburg-Eppendorf","OTHER",null,[9,14],{"name":10,"role":11,"phone":12,"phoneExt":7,"email":13},"Eckhard Schlemm","CONTACT","+49 152 228 98447","e.schlemm@uke.de",{"name":15,"role":11,"phone":16,"phoneExt":7,"email":17},"Thies Ingwersen","+49 152 228 34568","thi.ingwersen@uke.de",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":33},"University Medical Center Hamburg-Eppendorf","RECRUITING","Hamburg","Free and Hanseatic City of Hamburg","20246","Germany","DE",{"type":28,"coordinates":29},"Point",[30,31],9.99302,53.55073,{"lat":31,"lon":30},[34],{"name":10,"role":11,"phone":35,"phoneExt":7,"email":13},"0049 152 229 98447",{"type":37,"investigatorFullName":10,"investigatorTitle":38,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100573028","imaging-and-serological-biomarkers-of-autonomic-dysfunction-after-ischemic-stroke-100573028",false,"NCT06740942","Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke","ARIADNE","Inclusion Criteria:\n\n* Diagnosis of either\n\n  * acute ischemic stroke with either an ischemic lesion visible on CT\u002FMRI or persistent focal deficits 24 hours after symptom onset, or\n  * Transient ischemic attack with transient clinical deficits including motor or speech disturbance and not restricted to isolated vertigo\u002Fdizziness, visual disturbance, or sensory disturbance.\n* symptom onset within 72h prior to hospital admission,\n* a pre-stroke\u002FTIA ability to walk without help from another person (modified Rankin scale score \\\u003C 4),\n* age \\> 18 years, and\n* informed consent by either the patient or a legal representative (including a spouse)\n\nExclusion Criteria:\n\n* In-hospital stroke,\n* contraindications to MR imaging (e.g., claustrophobia, pregnancy, pacemakers, implants),\n* known moderate to severe dementia,\n* previous structural brain damage (except leukoariosis due to cerebral small vessel disease),\n* hemodynamically relevant stenosis of the common or internal carotid artery, or\n* left heart failure with estimated left ventricular ejection fraction \\\u003C 50%,\n* concomitant systemic illness that can lead to dysautonomia, such as an active infection, thyroid disease, or neurodegenerative disorder (e.g. PD, MSA).","ALL","18 Years",{"count":49,"type":50},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to\n\n* to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients;\n* to evaluate the influence of lesion location on autonomic dysfunction;\n* to identify patterns of structural and functional brain connectivity within the central autonomic control circuits associated with autonomic dysfunction; and\n* to explore causal models of the link between brain lesions; cardiac, immunological and endocrine biomarkers; and dysautonomia.\n\nResearchers will compare patients with acute ischemic stroke to patients with transient ischemic attacks to study the effect of acute ischemic brain lesions.\n\nParticipants will\n\n* undergo cardiovascular autonomic function testing;\n* receive structural and functional MR imaging;\n* provide blood samples for determinaton of serological biomarkers auf dysautonomia.",[54,55],"Acute Ischemic Stroke","Transient Ischemic Attack",[57,58,59,60,61,62,63,64,65,66,67,68,69,70],"Autonomic dysfunction","cardiovascular dysregulation","brain-heart axis","stroke-heart syndrome","acute ischemic stroke","transient ischemic attack","autonomic function test","central autonomic network","network lesion mapping","lesion symptom mapping","resting-state fMRI","functional brain network","structural brain network","diffusion tensor imaging","2026-05-01",{"date":73,"type":74},"2026-05-07","ACTUAL",{"date":76,"type":74},"2025-08-04",{"date":78,"type":50},"2026-12",{"name":5,"class":6},1]