[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100475368":3},{"organization":4,"armGroups":7,"interventions":38,"overallOfficials":44,"centralContacts":49,"locations":58,"responsibleParty":78,"collaborators":43,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":43,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":43,"enrollmentInfo":90,"targetDuration":43,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":43,"overallStatus":61,"whyStopped":43,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"University of California, Irvine","OTHER",[8,14,18,22,26,30,34],{"label":9,"type":10,"description":11,"interventionNames":12},"Brushing with LivFresh Dental Gel","ACTIVE_COMPARATOR","Subjects will brush twice daily for the study duration with LivFresh Dental Gel with a standard Oral B ProFlexR toothbrush and will be trained in standard sulcular brushing technique. Subjects will brush their teeth two hours prior to each visit and refrain from eating from that time onwards until after their visit. Plaque levels, gingival inflammation, and sulcus bleeding will be recorded. A standardized periodontal probe will be used to measure pockets. Subjects will expectorate into a graduated cylinder for 5 minutes and their saliva production will be measured. Saliva will not be stored or analyzed in any way. Subjects will be photographed and evaluated on all study dates by the same blinded, pre-calibrated investigator. Photographs will be recorded using a standard dental intraoral camera, which only records intraoral images. These photos will not show the subject's face but will focus on the subject's mouth.",[13],"Other: OTC Toothpastes or Mouthrinses",{"label":15,"type":10,"description":16,"interventionNames":17},"Brushing with LivFree Dental Gel","Subjects will brush twice daily for the study duration with LivFree Dental Gel with a standard Oral B ProFlexR toothbrush and will be trained in standard sulcular brushing technique. Subjects will brush their teeth two hours prior to each visit and refrain from eating from that time onwards until after their visit. Plaque levels, gingival inflammation, and sulcus bleeding will be recorded. A standardized periodontal probe will be used to measure pockets. Subjects will expectorate into a graduated cylinder for 5 minutes and their saliva production will be measured. Saliva will not be stored or analyzed in any way. Subjects will be photographed and evaluated on all study dates by the same blinded, pre-calibrated investigator. Photographs will be recorded using a standard dental intraoral camera, which only records intraoral images. These photos will not show the subject's face but will focus on the subject's mouth.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Brushing with AIM Dental Gel","Subjects will brush twice daily for the study duration with AIM Dental Gels with a standard Oral B ProFlexR toothbrush and will be trained in standard sulcular brushing technique. Subjects will brush their teeth two hours prior to each visit and refrain from eating from that time onwards until after their visit. Plaque levels, gingival inflammation, and sulcus bleeding will be recorded. A standardized periodontal probe will be used to measure pockets. Subjects will expectorate into a graduated cylinder for 5 minutes and their saliva production will be measured. Saliva will not be stored or analyzed in any way. Subjects will be photographed and evaluated on all study dates by the same blinded, pre-calibrated investigator. Photographs will be recorded using a standard dental intraoral camera, which only records intraoral images. These photos will not show the subject's face but will focus on the subject's mouth.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Brushing with Crest Prohealth Dental Gel","Subjects will brush twice daily for the study duration with Crest Prohealth Dental Gel with a standard Oral B ProFlexR toothbrush and will be trained in standard sulcular brushing technique. Subjects will brush their teeth two hours prior to each visit and refrain from eating from that time onwards until after their visit. Plaque levels, gingival inflammation, and sulcus bleeding will be recorded. A standardized periodontal probe will be used to measure pockets. Subjects will expectorate into a graduated cylinder for 5 minutes and their saliva production will be measured. Saliva will not be stored or analyzed in any way. Subjects will be photographed and evaluated on all study dates by the same blinded, pre-calibrated investigator. Photographs will be recorded using a standard dental intraoral camera, which only records intraoral images. These photos will not show the subject's face but will focus on the subject's mouth.",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Brushing with Parodontax Dental Gel","Subjects will brush twice daily for the study duration with Parodontax Dental Gel with a standard Oral B ProFlexR toothbrush and will be trained in standard sulcular brushing technique. Subjects will brush their teeth two hours prior to each visit and refrain from eating from that time onwards until after their visit. Plaque levels, gingival inflammation, and sulcus bleeding will be recorded. A standardized periodontal probe will be used to measure pockets. Subjects will expectorate into a graduated cylinder for 5 minutes and their saliva production will be measured. Saliva will not be stored or analyzed in any way. Subjects will be photographed and evaluated on all study dates by the same blinded, pre-calibrated investigator. Photographs will be recorded using a standard dental intraoral camera, which only records intraoral images. These photos will not show the subject's face but will focus on the subject's mouth.",[13],{"label":31,"type":10,"description":32,"interventionNames":33},"Brushing with Colgate Total Dental Gel","Subjects will brush twice daily for the study duration with Colgate Total Dental Gel with a standard Oral B ProFlexR toothbrush and will be trained in standard sulcular brushing technique. Subjects will brush their teeth two hours prior to each visit and refrain from eating from that time onwards until after their visit. Plaque levels, gingival inflammation, and sulcus bleeding will be recorded. A standardized periodontal probe will be used to measure pockets. Subjects will expectorate into a graduated cylinder for 5 minutes and their saliva production will be measured. Saliva will not be stored or analyzed in any way. Subjects will be photographed and evaluated on all study dates by the same blinded, pre-calibrated investigator. Photographs will be recorded using a standard dental intraoral camera, which only records intraoral images. These photos will not show the subject's face but will focus on the subject's mouth.",[13],{"label":35,"type":10,"description":36,"interventionNames":37},"Rinsing with Lumineux or Listerine Mouthwashes","Subjects will be asked to rinse twice daily with 1 capful for 1 minute with Lumineux or Listerine Mouthwashes directly after brushing their teeth, while continuing with their usual oral hygiene protocol. Plaque levels, gingival inflammation, and sulcus bleeding will be recorded. A standardized periodontal probe will be used to measure pockets. Subjects will expectorate into a graduated cylinder for 5 minutes and their saliva production will be measured. Saliva will not be stored or analyzed in any way. Subjects will be photographed and evaluated on all study dates by the same blinded, pre-calibrated investigator. Photographs will be recorded using a standard dental intraoral camera, which only records intraoral images. These photos will not show the subject's face but will focus on the subject's mouth.",[13],[39],{"type":6,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"OTC Toothpastes or Mouthrinses","OTC Toothpastes or mouthrinses used according to standard of care",[19,31,23,15,9,27,35],null,[45],{"name":46,"affiliation":47,"role":48},"Dr. Petra Wilder-Smith","Beckman Laser Institute University of California Irvine","PRINCIPAL_INVESTIGATOR",[50,54],{"name":46,"role":51,"phone":52,"phoneExt":43,"email":53},"CONTACT","949-824-7632","pwsmith@uci.edu",{"name":55,"role":51,"phone":56,"phoneExt":43,"email":57},"Nicole Wakida, PhD","949-824-4360","nwakida@uci.edu",[59],{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Beckman Laser Institute and Medical Clinic","RECRUITING","Irvine","California","92617","United States","US",{"type":68,"coordinates":69},"Point",[70,71],-117.82311,33.66946,{"lat":71,"lon":70},[74,77],{"name":75,"role":51,"phone":52,"phoneExt":43,"email":76},"Petra Wilder-Smith, DDS, PhD","pwsmith@hs.uci.edu",{"name":55,"role":51,"phone":56,"phoneExt":43,"email":57},{"type":48,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Petra E. Wilder-Smith","Professor of Surgery and Director of Dentistry","100475368","imaging-based-assessment-of-oral-biofilm-and-gingival-health-100475368",false,"NCT05470023","Imaging-based Assessment of Oral Biofilm and Gingival Health","Inclusion Criteria:\n\n* At least 18 years of age or older\n* In good general health\n\nExclusion Criteria:\n\n* History of allergy or intolerance of oral hygiene products such as toothpastes and mouthrinses",true,"ALL","18 Years",{"count":91,"type":92},275,"ESTIMATED","INTERVENTIONAL",[95],"NA","The purpose of this research study is to develop a better way of measuring the health of patients' mouth using photographs and imaging software. The investigators will also study the specific effects of individual toothpastes and mouthwashes on oral health.\n\nParticipants who have volunteered to be in the study will be asked to use a toothpaste or over a period of 7 days to 6 months. The investigators will determine the participants' oral plaque levels, gum health, and saliva (spit) production with clinical exams as well as photographs of the participants' mouths. It is the hope of the study team to find better ways of assessing the health of patients' mouths and to identify whether gum health can be improved by specific toothpastes or mouthwashes.",[98,99],"Plaque, Dental","Gingivitis","2025-12-16",{"date":102,"type":103},"2025-12-23","ACTUAL",{"date":105,"type":103},"2022-09-01",{"date":107,"type":92},"2028-12",{"name":5,"class":6},1]