[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100487970":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":40,"centralContacts":44,"locations":50,"responsibleParty":71,"collaborators":23,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":23,"eligibilityCriteria":80,"healthyVolunteers":76,"sex":81,"minAge":82,"maxAge":23,"enrollmentInfo":83,"targetDuration":23,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":23,"overallStatus":53,"whyStopped":23,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Icahn School of Medicine at Mount Sinai","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with INOCA","EXPERIMENTAL","Patients to undergo coronary angiogram and\u002For coronary CT angiogram for suspected ischemic symptoms of angina and dyspnea but do not have obstructive epicardial coronary artery disease.",[13,14,15,16],"Radiation: PET imaging","Radiation: Coronary CT angiogram","Procedure: Functional Angiography","Procedure: Treadmill exercise stress study",[18,24,28,36],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"RADIATION","PET imaging","PET imaging visit, which will take approximately 1-2 hours.",[9],null,{"type":19,"name":25,"description":26,"armGroupLabels":27,"otherNames":23},"Coronary CT angiogram","A coronary CT angiogram if the participant has not had one recently.",[9],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"PROCEDURE","Functional Angiography","A subset of patients with abnormal results on cardiac PET myocardial perfusion imaging study (estimated number of patients = 12) will be invited to participate in an invasive sub-study wherein they would undergo detailed invasive coronary physiology evaluation.\n\nFunctional Angiography (coronary reactivity test- CRT): is an angiography procedure done in the catheterization laboratory. It evaluates the coronary artery microcirculation and how the blood vessels respond to different medications.",[9],[34,35],"coronary reactivity test","CRT",{"type":29,"name":37,"description":38,"armGroupLabels":39,"otherNames":23},"Treadmill exercise stress study","A treadmill exercise stress study",[9],[41],{"name":42,"affiliation":5,"role":43},"Krishna Patel, MBBS, MSc","PRINCIPAL_INVESTIGATOR",[45],{"name":46,"role":47,"phone":48,"phoneExt":23,"email":49},"Lilia Soriano, BS","CONTACT","(929) 736-1828","lilia.soriano@mountsinai.org",[51],{"facility":52,"status":53,"city":54,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Mount Sinai Morningside","RECRUITING","New York","10025","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-74.00597,40.71427,{"lat":62,"lon":61},[65,66,69],{"name":42,"role":43,"phone":23,"phoneExt":23,"email":23},{"name":67,"role":68,"phone":23,"phoneExt":23,"email":23},"Jagat Narula, MD, PhD","SUB_INVESTIGATOR",{"name":70,"role":68,"phone":23,"phoneExt":23,"email":23},"Leslee Shaw, PhD",{"type":43,"investigatorFullName":72,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"Krishna Patel","Assistant Professor of Medicine (Cardiology) and Population Health Science and Policy","100487970","imaging-coronary-microvascular-dysfunction-cmd-study-100487970",false,"NCT05634031","Imaging Coronary Microvascular Dysfunction (CMD) Study","Development and Validation of a Non-invasive Algorithm for Diagnosis of Microvascular Angina Among Patients With Ischemia and Non-obstructive Coronary Artery Disease (IMAGING-CMD Study)","Inclusion criteria:\n\n* Patients with symptoms of exertional angina and\u002For dyspnea (confirmed on Seattle Angina Questionnaire and Rose Dyspnea Questionnaire)\n* Evidence of non-obstructive CAD on CCTA or coronary angiography (no stenosis \\>50% and\u002For FFR if performed \\>0.80)\n\nExclusion criteria:\n\n* Patients with reduced LVEF (\\\u003C50%) or diagnosis of cardiomyopathy\n* Patients with co-existent moderate or severe valve disease\n* Patients with eGFR \\\u003C30 ml\u002Fmin\u002Fm2\n* History of prior coronary revascularization\n* Non-coronary indication for CCTA or coronary angiogram determining eligibility\n* Contraindications to regadenoson (severe asthma\u002Fchronic obstructive pulmonary disease, brady-arrhythmias, or systolic blood pressure \\\u003C90 mm Hg)\n* Inability to provide informed consent\n* Pregnancy","ALL","18 Years",{"count":84,"type":85},70,"ESTIMATED","INTERVENTIONAL",[88],"NA","Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million people in the United States alone, and 112 million people globally. Despite this, 4 in 10 patients undergoing elective coronary angiography for angina and ischemia do not have evidence of obstructive coronary artery disease (CAD). This condition of ischemia with no obstructive CAD (INOCA) is associated with high clinical and economic morbidity, as these patients have a higher rate of repeat procedures and hospitalizations, worse quality of life, future adverse cardiovascular events and frequent time missed from work.\n\nThe overall objective of this study is to develop and validate a non-invasive algorithm for diagnosis and management of patients with INOCA and suspected microvascular dysfunction centered around cardiac PET MPI. A secondary goal of the study is to assess for improvement in patient symptoms, function and quality of life from PET-guided management of CMD in patients with INOCA.\n\nThis study will take place at Mount Sinai Morningside in the PET and CTunit on the 3rd floor. The sub-study will occur at Mount Sinai Morningside Cath Lab on the 3rd floor. The study will enroll an estimated total of 70 subjects, 12 of which will also participate in the sub-study. The study is estimated to last 2 years.",[91,92],"Angina","Non-obstructive Coronary Artery Disease","2025-04-11",{"date":95,"type":96},"2025-04-16","ACTUAL",{"date":98,"type":96},"2023-04-26",{"date":100,"type":85},"2027-03-01",{"name":5,"class":6},1]