[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100506018":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":34,"centralContacts":38,"locations":47,"responsibleParty":60,"collaborators":10,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":10,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":10,"enrollmentInfo":72,"targetDuration":75,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":49,"whyStopped":10,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Asan Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Brain metastases patients who received stereotactic radiosurgery",null,"Patients with brain metastases who received stereotactic radiosurgery",[13,14,15,16],"Diagnostic Test: Magnetic resonance imaging (MRI)","Diagnostic Test: Diffusion-weighted MRI","Diagnostic Test: Arterial spin labeling (ASL)","Diagnostic Test: Dynamic susceptibility contrast-MRI (DSC-MRI)",[18,23,26,30],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"DIAGNOSTIC_TEST","Magnetic resonance imaging (MRI)","Pre-and post-contrast enhanced T1-weighted image, T2-weighted image, fluid-attenuated inversion recovery image",[9],{"type":19,"name":24,"description":24,"armGroupLabels":25,"otherNames":10},"Diffusion-weighted MRI",[9],{"type":19,"name":27,"description":28,"armGroupLabels":29,"otherNames":10},"Arterial spin labeling (ASL)","Cerebral blood flow imaging parameter",[9],{"type":19,"name":31,"description":32,"armGroupLabels":33,"otherNames":10},"Dynamic susceptibility contrast-MRI (DSC-MRI)","Cerebral blood volume and vessel architectural imaging parameters",[9],[35],{"name":36,"affiliation":5,"role":37},"Ho Sung Kim, MD, PhD","PRINCIPAL_INVESTIGATOR",[39,43],{"name":36,"role":40,"phone":41,"phoneExt":10,"email":42},"CONTACT","+82230105682","radhskim@gmail.com",{"name":44,"role":40,"phone":45,"phoneExt":10,"email":46},"Ji Eun Park, MD, PhD","+82230101505","jieunp@gmail.com",[48],{"facility":5,"status":49,"city":50,"state":10,"zip":10,"country":51,"countryCode":10,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Seoul","South Korea",{"type":53,"coordinates":54},"Point",[55,56],126.9784,37.566,{"lat":56,"lon":55},[59],{"name":36,"role":40,"phone":41,"phoneExt":10,"email":42},{"type":37,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Ho Sung Kim","Professor","100506018","imaging-features-for-the-risks-for-recurrence-after-stereotactic-radiosurgery-in-brain-metastasis-100506018",false,"NCT05868928","Imaging Features for the Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis","Imaging Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis (IRRAS-BM)","Inclusion Criteria:\n\n1. Patients who underwent stereotactic radiosurgery (SRS, gamma-knife radiosurgery or cyberknife radiosurgery) for brain metastases\n2. Patients with lesions eligible for SRS :\n\n   * One to ten newly diagnosed brain metastases\n   * Patients without acute neurological symptom\n3. Patients with a Karnofsky performance status score of 70 or higher\n4. Patients who underwent brain MRI within 1 month of enrollment\n5. Patients with measurable enhancing lesions on MRI.\n6. Patients who have available reference standard (second-look surgery for recurrence) or available follow up imaging for clinic-radiologic reference standard.\n7. A longest diameter \\> 1.5 cm for tumor habitat analysis.\n\nExclusion criteria:\n\n1. Patients who have undergone prior brain surgery, SRS, or whole-brain radiation therapy.\n2. Patients who are diagnosed with leukemia, lymphoma, germ-cell tumor, small-cell lung cancer, leptomeningeal disease, or unknown primary tumor.\n3. Patients with age \\\u003C 18 years.\n4. Patients without baseline MRI.\n5. Patients with nonmeasurable enhancing lesions on MRI : all other lesions, including lesions with longest dimension \\\u003C 10 mm, lesions with borders that cannot be reproducibly measured, dural metastases, bony skull metastases, and leptomeningeal disease.","ALL","18 Years",{"count":73,"type":74},132,"ESTIMATED","24 Months","OBSERVATIONAL","This trial uses multi-parametric magnetic resonance imaging (MRI) to develop and validate imaging risk score to predict radiation necrosis in participants with brain metastasis treated with radiation therapy. Diagnostic procedures, such as multi-parametric magnetic resonance imaging (MRI), may improve the ability to diagnose radiation necrosis early and help establish treatment strategies.",[79,80],"Brain Metastases","Radiosurgery",[82,83,84,85,86],"Imaging","Habitat","Recurrence","Prediction","Radiation necrosis","2024-05-12",{"date":89,"type":90},"2024-05-14","ACTUAL",{"date":92,"type":90},"2023-12-07",{"date":94,"type":74},"2026-07-30",{"name":5,"class":6},1]