[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100327931":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":30,"centralContacts":36,"locations":46,"responsibleParty":63,"collaborators":30,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":30,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":30,"overallStatus":48,"whyStopped":30,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Massachusetts General Hospital","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Healthy Subjects","ACTIVE_COMPARATOR","Healthy subjects will receive an IV injection of 11C-Martinostat and undergo simultaneous PET-MRI.",[13,14],"Drug: 11C-Martinostat","Device: PET-MRI",{"label":16,"type":10,"description":17,"interventionNames":18},"Diabetes Patient Subjects","Patient subjects with diabetes will receive an IV injection of 11C-Martinostat and undergo simultaneous PET-MRI.",[13,14],{"label":20,"type":21,"description":22,"interventionNames":23},"Aortic Stenosis Patient Subjects","EXPERIMENTAL","Patient subjects with aortic stenosis will receive an IV injection of 11C-Martinostat and undergo simultaneous PET-MRI before and after transcatheter valve replacement.",[13,14],[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DRUG","11C-Martinostat","Imaging probe for evaluating the activity of histone deacetylase in the heart",[20,16,9],null,{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":30},"DEVICE","PET-MRI","Siemens PET-MR Scanner (Biograph MMR)",[20,16,9],[37,42],{"name":38,"role":39,"phone":40,"phoneExt":30,"email":41},"David E Sosnovik, MD","CONTACT","617-724-3407","dsosnovik@mgh.harvard.edu",{"name":43,"role":39,"phone":44,"phoneExt":30,"email":45},"Anne L Philip, MPH","617-726-0431","alphilip@mgh.harvard.edu",[47],{"facility":5,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"RECRUITING","Boston","Massachusetts","02114","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-71.05977,42.35843,{"lat":58,"lon":57},[61],{"name":62,"role":39,"phone":30,"phoneExt":30,"email":30},"David Sosnovik, MD",{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","David E Sosnovik","Associate Professor of Medicine","100327931","imaging-histone-deacetylase-in-the-heart-100327931",false,"NCT03549559","Imaging Histone Deacetylase in the Heart","Imaging of Histone Deacetylase in the Heart","Inclusion Criteria:\n\nGroup 1: Healthy Volunteers (n = 30)\n\n* Healthy adults with no known history of medical disease\n* Age 18-85 years\n* No history cardiovascular disease\n* Ability to provide informed consent\n\nGroup 2: Patients with Diabetes (n = 16)\n\n* Age 18-85 years\n* Diagnosis of diabetes\n* Echocardiogram within last 12 months showing no evidence of left ventricular hypertrophy or hemodynamic findings consistent with heart failure with preserved ejection fraction\n* Ability to provide informed consent\n\nGroup 3: Patients with Aortic Stenosis (n = 50)\n\n* Age 18-85 years\n* Echocardiogram or cardiac MRI scan within last 12 months documenting left ventricular hypertrophy and degenerative calcific aortic stenosis\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Known contraindication to MRI",true,"ALL","18 Years","85 Years",{"count":79,"type":80},96,"ESTIMATED","INTERVENTIONAL",[83],"NA","The overall goal of this PET-MR imaging trial is to evaluate 11C-Martinostat, a histone deacetylase targeted radioligand, in patients with aortic stenosis, individuals with diabetes, and healthy volunteers.",[86,87,88,89],"Heart Failure With Normal Ejection Fraction","Left Ventricular Hypertrophy","Aortic Valve Stenosis","Diabetes","2025-12-18",{"date":92,"type":93},"2025-12-22","ACTUAL",{"date":95,"type":93},"2018-09-07",{"date":97,"type":80},"2026-09-01",{"name":5,"class":6},1]