[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100579067":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":54,"centralContacts":58,"locations":64,"responsibleParty":80,"collaborators":41,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":41,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":41,"enrollmentInfo":91,"targetDuration":41,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":66,"whyStopped":41,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"St. Jude Children's Research Hospital","OTHER",[8,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Survivors","EXPERIMENTAL","Adult survivor of acute lymphoblastic leukemia (ALL) enrolled in St. Jude Life Cohort (SJLIFE).",[13,14,15,16,17,18],"Diagnostic Test: Magnetic Resonance Imaging","Diagnostic Test: Magnetic Resonance Spectroscopy","Other: Physical function assessment","Other: Peripheral blood sample","Other: Skeletal muscle biopsy","Diagnostic Test: Muscle Ultrasound",{"label":20,"type":10,"description":21,"interventionNames":22},"Control","Control participants are not a close relative of someone who has received treatment for childhood cancer or a similar illness; age\u002Fsex-matched healthy volunteers and recruited from SJLIFE Control cohort and may be recruited from new SJLIFE Controls.",[13,14,15,16,17,18],[24,31,37,42,46,50],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DIAGNOSTIC_TEST","Magnetic Resonance Imaging","Non-invasive MRI will be used to measure the major muscle groups in the calf muscle mtOXPHOS in childhood survivors of Acute Lymphoblastic Leukemia (ALL) in SJLIFE cohort and community controls and measure how muscle mitochondria produce energy to function.",[20,9],[30],"MRI",{"type":25,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Magnetic Resonance Spectroscopy","Non-invasive MRS will be used to measure the major muscle groups in the calf muscle mtOXPHOS in childhood survivors of Acute Lymphoblastic Leukemia (ALL) in SJLIFE cohort and community controls and measure how muscle mitochondria produce energy to function.",[20,9],[36],"MRS",{"type":6,"name":38,"description":39,"armGroupLabels":40,"otherNames":41},"Physical function assessment","As part of the SJLIFE visit in the Human Performance Lab, the participant's physical health will be assessed by testing muscle strength, physical function, and lean muscle mass.",[20,9],null,{"type":6,"name":43,"description":44,"armGroupLabels":45,"otherNames":41},"Peripheral blood sample","Peripheral blood sample will be used to evaluate muscle morphology, mitochondrial health and epigenetic differences in the muscles of survivors and age\u002Fsex-matched community controls.",[20,9],{"type":6,"name":47,"description":48,"armGroupLabels":49,"otherNames":41},"Skeletal muscle biopsy","Muscle biopsy will be used to evaluate muscle morphology, mitochondrial health and epigenetic differences in muscles of survivors and age\u002Fsex-matched community controls.",[20,9],{"type":25,"name":51,"description":52,"armGroupLabels":53,"otherNames":41},"Muscle Ultrasound","Bilateral quadriceps and calf muscle ultrasound will be used to measure muscle volume by calculating the cross-sectional area using the Cavalieri method.",[20,9],[55],{"name":56,"affiliation":5,"role":57},"Puneet Bagga, PhD","PRINCIPAL_INVESTIGATOR",[59,63],{"name":56,"role":60,"phone":61,"phoneExt":41,"email":62},"CONTACT","888-226-4343","referralinfo@stjude.org",{"name":56,"role":60,"phone":41,"phoneExt":41,"email":62},[65],{"facility":5,"status":66,"city":67,"state":68,"zip":69,"country":70,"countryCode":71,"cosmosGeoPoint":72,"geoPoint":77,"contacts":78},"RECRUITING","Memphis","Tennessee","38105","United States","US",{"type":73,"coordinates":74},"Point",[75,76],-90.04898,35.14953,{"lat":76,"lon":75},[79],{"name":56,"role":60,"phone":61,"phoneExt":41,"email":62},{"type":81,"investigatorFullName":41,"investigatorTitle":41,"investigatorAffiliation":41,"oldNameTitle":41,"oldOrganization":41},"SPONSOR","100579067","imaging-skeletal-muscle-mitochondrial-oxphos-activity-in-acute-lymphoblastic-leukemia-survivors-100579067",false,"NCT06819475","Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors","Inclusion Criteria:\n\n* Survivor- or Control-Participant is age 18 years old or older at time of consent and enrolled in SJLIFE.\n* Survivor- Participant is childhood ALL survivor\n* Survivor- or Control Participant has low muscle mass as defined by relative lean mass z-score of less than or equal to -0.5 SD (lean mass divided by height in meters squared).\n* Survivor - Participant is able and willing to give informed consent\n\nExclusion Criteria:\n\n* Survivor-Participant has history of cranial radiation.\n* Survivor- or Control-Participant has implanted medical devices or metal that would interfere with MRI or MRS\n* Female Survivor- or Control-Participant is pregnant.\n* Survivor- or Control-Participant is taking anticoagulants (e.g. aspirin, apixaban, coumadin, edoxaban, rivaroxaban)\n* Survivor- or Control-Participant weighs more than 300 pounds.\n* Survivor- or Control-Participant is allergic to local anesthetic (i.e., lidocaine, bupivacaine).\n* Survivor- or Control-Participant cannot lie flat on his\u002Fher back for 90 minutes or longer\n* Survivor- or Control-Participant has a current history of peripheral motor neuropathy.",true,"ALL","18 Years",{"count":92,"type":93},60,"ESTIMATED","INTERVENTIONAL",[96],"NA","The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow.\n\nPrimary Objective\n\n• To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls.\n\nSecondary Objective\n\n* To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors.\n* To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.",[99,100],"Childhood Cancer","Muscle Weakness",[102,103,104,89,105],"Survivor","Acute Lymphoblastic Leukemia","Adult","Healthy Volunteer","2026-05-14",{"date":108,"type":109},"2026-05-18","ACTUAL",{"date":111,"type":109},"2025-06-02",{"date":113,"type":93},"2028-01",{"name":5,"class":6},1]