[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100551289":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":61,"centralContacts":65,"locations":73,"responsibleParty":93,"collaborators":96,"id":102,"slug":103,"hasResults":104,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":28,"eligibilityCriteria":108,"healthyVolunteers":109,"sex":110,"minAge":111,"maxAge":28,"enrollmentInfo":112,"targetDuration":28,"studyType":115,"phases":116,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":75,"whyStopped":28,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":138},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Speech behavior and functional imaging","EXPERIMENTAL","Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.",[13,14,15,16,17,18,19,20,21],"Behavioral: Neural responses to speech functional localizer","Behavioral: Neural responses to silent articulation","Behavioral: Neural responses to self vs. externally generated speech","Behavioral: Event-related potentials for speech","Behavioral: Neural responses to induced speech errors","Behavioral: Neural responses to sensory-motor adaptation","Behavioral: Speech production behaviors","Behavioral: Auditory acuity testing","Behavioral: Neural responses to learning a non-speech auditory motor behavior",[23,29,33,37,41,45,49,53,57],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"BEHAVIORAL","Neural responses to speech functional localizer","Measuring speech-related brain activity using fMRI during a speech listening task.",[9],null,{"type":24,"name":30,"description":31,"armGroupLabels":32,"otherNames":28},"Neural responses to silent articulation","Measuring speech-related brain activity using fMRI during a silent articulation task.",[9],{"type":24,"name":34,"description":35,"armGroupLabels":36,"otherNames":28},"Neural responses to self vs. externally generated speech","Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.",[9],{"type":24,"name":38,"description":39,"armGroupLabels":40,"otherNames":28},"Event-related potentials for speech","Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech",[9],{"type":24,"name":42,"description":43,"armGroupLabels":44,"otherNames":28},"Neural responses to induced speech errors","Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.",[9],{"type":24,"name":46,"description":47,"armGroupLabels":48,"otherNames":28},"Neural responses to sensory-motor adaptation","Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.",[9],{"type":24,"name":50,"description":51,"armGroupLabels":52,"otherNames":28},"Speech production behaviors","Behavioral measurements of speech during reading passages and words",[9],{"type":24,"name":54,"description":55,"armGroupLabels":56,"otherNames":28},"Auditory acuity testing","Measurements of auditory acuity during listening tasks.",[9],{"type":24,"name":58,"description":59,"armGroupLabels":60,"otherNames":28},"Neural responses to learning a non-speech auditory motor behavior","Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.",[9],[62],{"name":63,"affiliation":5,"role":64},"Jason W Bohland, Ph.D.","PRINCIPAL_INVESTIGATOR",[66,70],{"name":63,"role":67,"phone":68,"phoneExt":28,"email":69},"CONTACT","412-383-3416","j.bohland@pitt.edu",{"name":71,"role":67,"phone":28,"phoneExt":28,"email":72},"Alexander Ocampo, B.A.","amo104@pitt.edu",[74],{"facility":5,"status":75,"city":76,"state":77,"zip":78,"country":79,"countryCode":80,"cosmosGeoPoint":81,"geoPoint":86,"contacts":87},"RECRUITING","Pittsburgh","Pennsylvania","15260","United States","US",{"type":82,"coordinates":83},"Point",[84,85],-79.99589,40.44062,{"lat":85,"lon":84},[88,90,92],{"name":89,"role":67,"phone":68,"phoneExt":28,"email":69},"Jason Bohland, Ph.D.",{"name":91,"role":67,"phone":28,"phoneExt":28,"email":72},"Alexander Ocampo, BA",{"name":63,"role":64,"phone":28,"phoneExt":28,"email":28},{"type":64,"investigatorFullName":94,"investigatorTitle":95,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Jason Bohland","Assistant Professor",[97,99],{"name":98,"class":6},"Northwestern University",{"name":100,"class":101},"National Institute on Deafness and Other Communication Disorders (NIDCD)","NIH","100551289","imaging-speech-in-neurotypical-adults-and-individuals-with-cerebellar-stroke-100551289",false,"NCT06458153","Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke","High-resolution Functional Imaging of Speech-induced Sensory Modulation","Inclusion Criteria:\n\nCohort 1 (neurotypical adults):\n\n* Age 18-49\n* Right-handed\n* Native English speaker\n\nCohort 2 (people with cerebellar lesions):\n\n* Age 18 or older\n* Right-handed\n* Native English speaker\n* History of cerebellar stroke\n\nCohort 3 (controls matched to Cohort 2)\n\n* Age 18 or older\n* Right-handed\n* Native English speaker\n\nExclusion Criteria:\n\nCohort 1 (neurotypical adults):\n\n* Presence of MRI risk factors: metal and\u002For electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant\n* History of neurological \u002F neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)\n* Hearing loss, defined by pure tone thresholds \\>25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz\n* Clinical diagnosis and\u002For treatment for schizophrenia or other psychotic disorders\n* Clinical diagnosis and\u002For treatment for neurocognitive disorders (e.g., dementia, delirium)\n* Presence of a severe and unmanaged, clinically diagnosed attention disorder\n* Clinically diagnosed with or treated for a speech, language, or hearing disorder\n* Head circumference greater than 60cm or weight greater than 300 pounds\n* History of severe claustrophobia\n* Currently pregnant\n\nCohort 2 (people with cerebellar lesions):\n\n* Presence of MRI risk factors: metal and\u002For electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant\n* History of neurological \u002F neurodegenerative disease or severe brain injury other than stroke\n* Hearing loss, defined by pure tone thresholds \\>50 dB HL at octave frequencies between 250-4000 Hz\n* Clinical diagnosis and\u002For treatment for schizophrenia or other psychotic disorders\n* Clinical diagnosis and\u002For treatment for neurocognitive disorders (e.g., dementia, delirium)\n* Presence of a severe and unmanaged, clinically diagnosed attention disorder\n* Head circumference greater than 60cm or weight greater than 300 pounds\n* History of severe claustrophobia\n* Currently pregnant\n\nCohort 3 (controls matched to Cohort 2):\n\n* Presence of MRI risk factors: metal and\u002For electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant\n* History of neurological \u002F neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)\n* Hearing loss, defined by pure tone thresholds \\>50 dB HL at octave frequencies between 250-4000 Hz\n* Clinical diagnosis and\u002For treatment for schizophrenia or other psychotic disorders\n* Clinical diagnosis and\u002For treatment for neurocognitive disorders (e.g., dementia, delirium)\n* Presence of a severe and unmanaged, clinically diagnosed attention disorder\n* Clinically diagnosed with or treated for a speech, language, or hearing disorder\n* Head circumference greater than 60cm or weight greater than 300 pounds\n* History of severe claustrophobia\n* Currently pregnant",true,"ALL","18 Years",{"count":113,"type":114},100,"ESTIMATED","INTERVENTIONAL",[117],"NA","The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:\n\n1. What regions of the brain's sensory systems show changes in their activity related to speech?\n2. To what extent do these regions help listeners detect and correct speech errors?\n3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?\n\nParticipants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).",[120,121],"Stroke","Cerebellum",[123,124,125,126,127,128],"fmri","speech production","cerebellum","auditory-motor integration","speech motor control","neuroimaging","2026-06-16",{"date":131,"type":132},"2026-06-18","ACTUAL",{"date":134,"type":132},"2025-05-27",{"date":136,"type":114},"2028-07",{"name":5,"class":6},1]